简介:AbstractPhenuiviridae, a member of the Bunyavirales order, can lead to significant human morbidity and mortality. Various phenuiviruses target specific cellular proteins and have strategies to counteract the effects of type I interferon (IFN). Previous studies have shown that phenuiviruses infection inhibits the synthesis of type I IFNs, and viral nonstructural proteins (NSs) had been further identified as an IFN antagonist. This study found that the NSs proteins of Dabie bandavirus (DBV), Sandfly fever Sicilian virus (SFSV), and Uukuniemi virus (UUKV) can inhibit Sendai virus-induced activation of IFN-β promoter and phosphorylation of IFN regulatory factor 3 (IRF3). Moreover, detailed analysis revealed that the phenuivirus NSs protein could directly interact with retinoic acid inducible gene-I (RIG-I) and degrade it via a proteasome-dependent pathway. In short, this study demonstrate a novel mechanism of phenuiviruses to resist host antiviral immunity, which may help understand these pathogens and suggest novel therapeutic approaches.
简介:摘要:港西区块主力层都在实施聚合物驱,通过近几年的调整,井网相对完善,开发指标较好。而对于非注聚的储层,因发育或是相对零星目前开发中主要存在两方面问题:开发存在的主要问题。①多年未调整,目前注采井网不完善,处于低效开发状态。区块总井数X口(X油X水),目前仅1注5采,日产油量仅5.1吨,采油速度为0.1%,处于低速低效开发状态。②油藏开发过程中,边水上侵速度较快,生产井含水快速上升。随着采出程度的增大,区块生产井无水生产期变短,边水一旦突破进入井底,含水快速上升,直至高含水,造成储量难以继续采出,影响单井的最终采收率。通过潜力论证分析:一是从分析成果图看,剩余油主要分布在水锥和主流线区间,作为重点剩余油挖潜目标。二是剩余油主要分在西38-X区块、西38-Y区块和西37-Z区块,纵向油层厚,平面范围较大。