Angiotensin-converting enzyme gene polymorphism and middle cerebral artery stenosis in a Chinese Han population-中国期刊网

摘要 Theangiotensin-convertingenzymegeneisacandidategeneofstroke.Thepresentstudyinvolved62healthyvolunteersand148patientswithmiddlecerebralarterystenosisasconfirmedbybraincolorultrasoundfromaHanpopulationinNorthChina,anddeterminedtheperipheralbloodangiotensin-convertingenzymegenotypeusingPCR-restrictionfragmentlengthpolymorphismanalysis.TheresultsshowedthatthefrequenciesoftheDDgenotypeandDallelewereincreasedinpatientswithmiddlecerebralarterystenosis,butthedifferencewasnotstatisticallysignificantcomparedwithhealthycontrols.ThefindingsofthisstudyontherelationshipbetweenstrokegenesandmiddlecerebralarterystenosisindicatenosignificantcorrelationbetweenthefrequenciesoftheDDgenotypeandDalleleofangiotensin-convertingenzymeandmiddlecerebralarterystenosisinthisHanpopulationfromNorthChina.Inthefuture,studieswillbecarriedouttoinvestigatecorrelationsbetweenmultiplestrokecandidategenesynergyandmiddlecerebralarterystenosistoprovideafoundationforthedevelopmentofgenetherapy.

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Angiotensin-converting enzyme gene polymorphism and middle cerebral artery stenosis in a Chinese Han population

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Angiotensin-converting enzyme gene polymorphism and middle cerebral artery stenosis in a Chinese Han population

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