Metabolism of minor isoforms of prion proteins Cytosolic prion protein and transmembrane prion protein-中国期刊网

摘要 Transmissiblespongiformencephalopathyorpriondiseaseistriggeredbytheconversionfromcellularprionproteintopathogenicprionprotein.Growingevidencehasconcentratedonprionproteinconfigurationchangesandtheircorrelationwithpriondiseasetransmissibilityandpathogenicity.Invivoandinvitrostudieshaveshownthatseveralcytosolicformsofprionproteinwithspecifictopologicalstructurecandestroyintracellularstabilityandcontributetoprionproteinpathogenicity.Inthisstudy,thelatestmolecularchaperonesystemassociatedwithendoplasmicreticulum-associatedproteindegradation,theendoplasmicreticulumresidentproteinquality-controlsystemandtheubiquitinationproteasomesystem,isoutlined.Themolecularchaperonesystemdirectlycorrelateswiththeprionproteindegradationpathway.Understandingthemolecularmechanismswillhelpprovideafascinatingavenueforfurtherinvestigationsonpriondiseasetreatmentandprionprotein-inducedneurodegenerativediseases.

1Akio Kawauchi Kayo Yoshida. Topology of Prion Proteins.基础数学,2012-04.
2Chen Cao,Dong Xiaoping. Therapeutic implications of prion diseases.医药卫生,2021-06.
3Yan Cai;Jing Yang;He Huang;Fang Li;Ganqiu Wu;Jing Yang;Xuegang Luo. Prokaryotic expression and purification of fibronectin leucine rich transmembrane protein 3 C-terminal domain proteins in rats.神经病学与精神病学,2009-02.
4Li-Xia Huang Yan-Jun Gong Jun Gu Bao-Juan Zeng Li-Hua Huang Qi-Li Feng. Expression, subcellular localization and protein-protein interaction of four isoforms of EcR/USP in the common cutworm.昆虫学,2015-01.
5Mahmood A. Mahdavi Yen-Han Lin. Prediction of Protein-Protein Interactions Using Protein Signature Profiling.分子生物学,2007-03.
6LI Wenzhao;MENG Wei;TIAN Pu. Impact of Stable Protein-protein Interaction on Protein Conformational Space.化学,2015-01.
7Khaled Sayed Ahmed Nahed H. Solouma Yasser M. Kadah. Determining the Relations between Protein Sub-Function Categories Based on Overlapping Proteins.计算机应用技术,2011-03.
8Gunjan Sharma;Susanta Kar;Writoban Basu Ball;Kuntal Ghosh;Pijush K Das. The curative effect of fucoidan on visceral leishmaniasis is mediated by activation of MAP kinases through specific protein kinase C isoforms.免疫学,2014-03.
9Xu Xi-Chao,Feng Jian-Guo,Tang Li-Ling. Lysosomal-associated protein transmembrane-4 beta: a novel potential biomarker for cancer therapy with multiple functions.医药卫生,2021-03.
10Limin LI;Waiki CHING;Yatming CHAN;Hiroshi MAMITSUKA. ON NETWORK-BASED KERNEL METHODS FOR PROTEIN-PROTEIN INTERACTIONS WITH APPLICATIONS IN PROTEIN FUNCTIONS PREDICTION.系统科学,2010-05.

Metabolism of minor isoforms of prion proteins Cytosolic prion protein and transmembrane prion protein

来源期刊

相关推荐

同分类资源更多

相关关键词

Metabolism of minor isoforms of prion proteins Cytosolic prion protein and transmembrane prion protein

来源期刊

相关推荐

同分类资源 更多

相关关键词

同分类资源更多