A 1,8-naphthalimide-derived turn-on fluorescent probe for imaging lysosomal nitric oxide in living cells-中国期刊网

摘要 Nitricoxidehasplayedanimportantroleinmanyphysiologicalandpathologicalprocessesasakindofimportantgassignalmolecules.Inthiswork,anewfluorescentprobeLysoNO-NaphfordetectingNOinlysosomesbasedon1,8-naphthalimidewasreported.LysoNO-Naphhassub-groupsofo-phenylenediamineasaNOreactionsiteand4-(2-aminoethyl)-morpholineasalysosome-targetablegroup.Thisprobeexhibitedgoodselectivityandhighsensitivity(4.57mmol/L)towardNOinawidepHrangefrom4to12.Furthermore,LysoNO-NaphcanbeusedforimagingNOinlysosomesinlivingcells.

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A 1,8-naphthalimide-derived turn-on fluorescent probe for imaging lysosomal nitric oxide in living cells

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A 1,8-naphthalimide-derived turn-on fluorescent probe for imaging lysosomal nitric oxide in living cells

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