摘要
Multidrugresistance(MDR)isamajorobstacletosuccessfulcancertreatmentandiscrucialtocancermetastasisandrelapse.CombinationtherapyisaneffectivestrategyforovercomingMDR.However,thedifferentpharmacokinetic(PK)profilesofcombineddrugsoftenunderminethecombinationeffectinvivo,especiallywhengreatlydifferentphysicochemicalproperties(e.g.,thoseofmacromoleculesandsmalldrugs)combine.Toaddressthisissue,nanotechnology-basedcodeliverytechniqueshavebeenactivelyexplored.Theypossessgreatadvantagesfortumortargeting,controlleddrugrelease,andidenticaldrugPKprofiles.Thus,apowerfultoolforcombinationtherapyisprovided,andthetranslationfrominvitrotoinvivoisfacilitated.Inthisreview,wepresentasummaryofvariouscombinationstrategiesforovercomingMDRandthenanotechnology-basedcombinationtherapy.
出版日期
2017年03月13日（中国期刊网平台首次上网日期，不代表论文的发表时间）
