3-53 Genistein Suppresses Radiaiton-induced Metastatic Potential of DNA-PKcs Positive Cells-中国期刊网

摘要 TheDNA-dependentproteinkinasecatalyticsubunit(DNA-PKcs)playsamajorroleinDNAdamagesignalingandrepair,andisalsofrequentlyover-expressedintumormetastasis.WeusedisogeniccelllinesexpressingdifferentlevelsofDNA-PKcstoinvestigatetheroleofDNA-PKcsinmetastaticdevelopment.Interestingly,ourresultsshowedthatX-rayirradiationinducedthemetastasisofDNA-PKcspositive(M059K)butnotnegative(M059J)cells;however,genisteincouldsuppresstheradiation-inducedmetastaticpotentialofM059Kcells(Fig.1).Theconcretemechanismsunderlyingthisphenomenonwillbeinvestigatednextyear.

1Zhou Xin;Zhang Hong. 3 - 79 DNA-PKcs Inhibition Sensitizes MCF-7 Cells to Carbon Ions Irradiation via Accelerated Telomere Reduction.物理,2013-01.
2MinHoJEONG;YoungHeeJIN;EunYoungKANG;WolSoonJO;HwanTaePARK;JaeDongLEE;YeoJinYOO;SooJinJEONG. The modulation of radiation-induced cell death by genistein in K562 cells：Activation of thymidine kinase 1.细胞生物学,2004-04.
3Liu Bin;Zheng Qian;Liu Yang;Li Jie;Song Jinge;Zhang Hong. 3-67 X-ray Radiation Promotes the Metastatic Potential of Tongue Squamous Cell Carcinoma Cells via Modulation of Biomechanical and Cytoskeletal Properties.物理,2015-01.
4Yan Wang;Blao Cai;Jing Sha;Ting-ting Wang;Run-ze Cai;Changqu Ma;Tao Han;Jun Du. Genistein suppresses the mitochondrial apoptotic pathway in hippocampal neurons in rats with Alzheimer's disease.神经病学与精神病学,2016-07.
5宋卉;盛小刚. Role of Dendritic Cells in Myocarditis Induced by Coxsackie B3 Virus in Mouse.心血管疾病,2002-02.
6Atsushi Asakura. Hematopoietic potential cells in skeletal muscle.细胞生物学,2007-10.
7Xuemei Fu. The immunogenicity of cells derived from induced pluripotent stem cells.免疫学,2014-01.
8Fengguang Gao;Xin Hui;Xianghuo He;Dafang Wan;Jianren Gu. Dysfunction of Murine Dendritic Cells Induced by Incubation with Tumor Cells.免疫学,2008-02.
9Li Xue,Wang Yong-Mei,Wang An,Li Yue,Wu Qi,Chen Huai-Yong. Sex-determining region Y-box 2-positive alveolar cells are responsive to bleomycin-induced lung injury.医药卫生,2021-03.
10周成斌;吕振声;祁周措;姚丽明;庄建. Differentiation of bone marrow stem cells into the cardiomyocyte-like cells induced by fetal cardiac supernatant with 6-bromoindirubin-3-oxime.心血管疾病,2012-01.

3-53 Genistein Suppresses Radiaiton-induced Metastatic Potential of DNA-PKcs Positive Cells

来源期刊

相关推荐

同分类资源更多

相关关键词

3-53 Genistein Suppresses Radiaiton-induced Metastatic Potential of DNA-PKcs Positive Cells

来源期刊

相关推荐

同分类资源 更多

相关关键词

同分类资源更多