HLA-DQA1 Polymorphism in Idiopathic Dilated Cardiomyopathy-中国期刊网

摘要 TodeterminewhetherthepossessionofcertainHLA-DQA1alleleswasassociatedwiththeriskofdevelopingidiopathicdilatedcardiomyopathy(IDC)andtosubstantiatetheroleofanautoimmunologicpathogenesisinIDC.TypetheallelesofHLA-DQA1bypolymerasechainreactionwithsequence-specificprimers(PCR-SSP)techniquein38patientsofidiopathicdilatedcardiomyopathy(7womenand31men),agedfrom17to56yearsoldwithdiagnosisbeingaccordingtoWorldHealthOrganizationcriteria(IDCgroup),in50patientsofend-stageheartfailureofknownetiology(18womenand32men),withagesrangingfrom34to72(HFgroup),andinthecontrolgroupconsistingofpresumably100healthysubjects(39womenand61men)fromthehealthsurvey,agedfrom30to59yearsold.ThefrequencyofHLA-DQA1*0501intheDCMpatientswassignificantlyelevatedthanthatintheHFandthecontrolgroup.MolecularanalysisoftheDQA1genepolymorphismperformedinthethreesubgroupsshowsanincreasedfrequencyofDQA1*0501amongpatientswithlessEF.TheHFgroupcarriesahighfrequencyofHLA-DQA1*0301.AnincreasedfrequencyofDQA1*0201andDQA1*0103wasfoundinthecontrolgroup.HLA-DQA1*0501isanassociatedgeneofidiopathicdilatedcardiomyopathyandthepossessionofDQA1*0301maybeindicativeoftheknownetiologicheartfailure,suggestingthatthemechanismsinvolvedinthepathogenesisofIDCandotherwiseheartfailurearedifferent.ImmunologicabnormalitiesmaybeamajorcontributortothesusceptibilityofdevelopingofIDC.

1WeiLiu;WeiminLi;NinglingSun. Association of HLA-DQ with Idiopathic Dilated Cardiomyopathy in a Northern Chinese Han Population.免疫学,2004-04.
2WEI LIU;WEI MIN LI;CHENG GAO;ZHENG WANG;RUI HONG ZHANG;YI HUI KONG. Cytotoxic T lymphocyte associated antigen-4 gene exon 1A49→G polymorphisms confer susceptibility to idiopathic dilated cardiomyopathy.基础医学,2005-02.
3Yangming Mao,Yanmin Liu,Jian Zhang,Yeqian Zhu,Xinguang Chen,Ling Sun,Yao Lu,Hongwu Chen,Weizhu Ju,Gang Yang,Pengcheng Zhao,Minglong Chen,Fengxiang Zhang. A nomogram predicting atrial fibrillation in patients with dilated cardiomyopathy.医药卫生,2022-12.
4Zhao Hong-Yan,Sun Ling,Zhu Ye-Qian,Chen Qiu-Shi,Zhu Wen-Wu,Toorabally Mohammad Bilaal,Chen Xin-Guang,Zhang Feng-Xiang. Prognostic value of free triiodothyronine in patients with dilated cardiomyopathy.医药卫生,2020-09.
5李文政李婷婷康晓静. 新疆维吾尔族系统性红斑狼疮自身抗体与HLA－DQA１等位基因的相关性.临床医学,2015-09.
6曾小林;杨天伦;孙明;马琦琳;吴声滨. Preliminary Survey on the Prevalence Rate of Hypertension in Patients with Dilated Cardiomyopathy.心血管疾病,2008-04.
7黄凯;朱树雄;尹瑞兴. A Study on Changes of the Plasma Endothelin Level in Patients with Dilated Cardiomyopathy.心血管疾病,2003-02.
8潘尚领;刘承武;龙桂芳;袁志刚;石文;林伟雄;陈萍;陈晶;陈文成;周小玲. The Polymorphism of the HLA-DRB1 Locus of the Guangxi Zhuang People and Its Comparison with the Main Surrounding Ethnic Groups.基础医学,2004-03.
9. A 17-year-old Male with Duchenne muscular dystrophy complicated with dilated cardiomyopathy and large left ventricular mural thrombosis.心血管疾病,2011-04.
10ChunxiaYan;RuilinWang;JingxiangLi;YajunDeng;DongyingWu;HongboZhang;HongxingZhang;LidongWang;ChunrongZhang;HaiyanSun;XiuqingZhang;JianWang;HuanmingYang;ShengbinLi. HLA-A Gene Polymorphism Defined by High-Resolution Sequence-Based Typing in 161 Northen Chinese Han People.分子生物学,2003-04.

HLA-DQA1 Polymorphism in Idiopathic Dilated Cardiomyopathy

来源期刊

相关推荐

同分类资源更多

相关关键词

HLA-DQA1 Polymorphism in Idiopathic Dilated Cardiomyopathy

来源期刊

相关推荐

同分类资源 更多

相关关键词

同分类资源更多