Differential regulation of survivin by p53 contributes to cell cycle dependent apoptosis-中国期刊网

摘要 Recentstudiesindicatethatcell-cyclecheckpointsaretightlycorrelatedwiththeregulationofapoptosis,inwhichp53playsanimportantrole.OurpresentworksshowthattheexpressionofE6/E7oncogenesofhumanpapillomavirusinHeLacellsisinhibitedinthepresenceofanti-tumorreagenttripchlorolide(TC),whichresultsintheup-regulationofp53inHeLacells.Interestingly,underthesameTC-treatment,thecellsattheearlyS-phasearemoresusceptibletoapoptosisthanthoseatthemiddleS-phasealthoughp53proteinisstabilizedtothesamelevelinbothsituations.Significantdifferenceisexhibitedbetweenthetwospecifiedexpressionprofiles.Furtheranalysisdemonstratesthatanti-apoptoticgenesurvivinisup-regulatedbyp53intheTC-treatedmiddle-Scells,whereasitisdown-regulatedbyp53intheTC-treatedearly-Scells.Takentogether,thepresentstudyindicatesthatthedifferentialp53-regulatedexpressionofsurvivinatdifferentstagesofthecellcycleresultsindifferentcellularoutputsunderthesameapoptosis-inducer.

1Keke Li,Jingkai Xu,Ke Xue,Ruixing Yu,Chengxu Li,Wenmin Fei,Xiaoli Ning,Yang Han,Ziyi Wang,Jun Shu,Yong Cui. Deficiency of two-pore segment channel 2 contributes to systemic lupus erythematosus via regulation of apoptosis and cell cycle.医药卫生,2022-12.
2JIARUIWU. Activation of p53 in gastric cancer cells by tripchlorolide specifically induces apoptosis.细胞生物学,2002-03.
3ZHANGShan－wen XIAOShao－wen 等. EFFECT OF ADENOVIRUS—MEDIATED p53 GENE TRANSFER ON APOPTOSIS AND RADIOSENSITIVITY OF HUMAN.肿瘤,2003-01.
4Jingwen Bai;Yaochen Li;Guojun Zhang. Cell cycle regulation and anticancer drug discovery.肿瘤,2017-04.
5. 神秘P53.药学,2002-01.
6季加孚;张霁;焦春雨;顾晋;谭立新;张平;李培详. POST-TRANSCRIPTIONAL REGULATION OF P21WAF1/CIP1 BY P53.肿瘤,2001-02.
7Zhe-Wei Zhang;Zhi-Ming Yang;Yi-Chun Zheng;Zhao-Dian Chen. Transgelin induces apoptosis of human prostate LNCaP cells through its interaction with p53.泌尿科学,2010-02.
8甘华田;欧阳钦;王一平;李甘地;马洪升;杨正兵;李奉媛. ASSOCIATION OF EXPRESSION OF P53 PROTEIN WITH CELL PROLIFERATIVE ACTIVITY AND PROGNOSIS IN COLORECTAL CANCER.肿瘤,1997-02.
9陈江崔彬. 甲状腺乳头状癌Survivin、p53表达与临床病理特征.公共卫生与预防医学,2010-12.
10Sheng-Cai Lin Qinxi Li. Axin bridges Daxx to p53.细胞生物学,2007-04.

Differential regulation of survivin by p53 contributes to cell cycle dependent apoptosis

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Differential regulation of survivin by p53 contributes to cell cycle dependent apoptosis

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