摘要
Objective:Tostudytheexpressionofdendriticcellsinhumanrenalcellcarcinomaandexplorethecause,sotorevealthemechanismofescapingimmunesurveillanceinRCC.Methods:TheexpressionsofCD83+DCS,CD1a+DCS,VEGFandTGF-β1intumoral,peritumoralandnormalkidneytissuesofRCCin30casesweredetectedbyimmunohistochemistryusingstreptavidin/peroxidese(SP)Results:CD83+DCSweremainlylocatedintheperitumoralareas;whereasCD1a+DCS、weremainlyretainedwithinthecancernests.ThenumberofCD83+DCSwasinverselycorrelatedwiththeclinicalstage(P<0.05);buttherewerenosignificantcorrelationsbetweenthenumberofCD1a+DCS、andtheclinicalstage(P>0.05).TheexpressionsofCD83+DCSandCD1a+DCShavesignificantdifferencebetweenthetumoral,peritumoralandnormalkidneytissues(P<0.001).TheexpressionofVEGFandTGF-β1weresignificantlylowerinsampleswithhighlyinfiltratingCD83+DCS(P<0.05);WhereasCD1a+DCSwerenot(P>0.05).Conclusion:DChasthetendencytogatheringintumor,butbecauseoftheimmunosuppressivecytokins,forexampleVEGFandTGF-β1,inhibitsthematurationofDC,therearelessmatureTIDCS(CD83+TIDCS)inthetumoraltissues,theyaremainlylocatedintheperitumoralareas.ThismaycontributetothemechanismofescapingimmunesurveillanceinRCC.
出版日期
2005年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
