探讨糖尿病早期肾损伤应用尿微量白蛋白 /肌酐比值与胱抑素 C检验的可行性研究

摘要 　　 [摘要 ] 目的 探讨并研究糖尿病早期肾损伤应用微量白蛋白 /肌酐比值与胱抑素 C检验的可行性。方法 此次研究的对象是选 2015年 9月— 2016年 11月在该院内分泌科进行治疗的糖尿病患者 80例，将其临床资料进行回顾性分析，并根据尿微量白蛋白排泄率的正常与否进行分组，每组 40例。对尿微量白蛋白肌酐比值及血胱抑素进行检测。 结果 尿微量白蛋白排泄正常组患者的尿微量白蛋白肌酐比值为（ 1.2±0.4） mg/mmoL，尿微量白蛋白排泄增高组患者的尿微量白蛋白肌酐比值为（ 3.9±1.5） mg/mmoL，两组之间数据差异有统计学意义（ P<0.05）；尿微量白蛋白排泄正常组患者的胱抑素 C含量为（ 0.7±0.3） mg/L，尿微量白蛋白排泄增高组患者的胱抑素 C含量为（ 1.6±0.5） mg/L，差异有统计学意义（ P<0.05）。 结论 尿微量白蛋白肌酐比值、胱抑素 C与尿微量白蛋白排泄密切相关，采用尿微量白蛋白肌酐比值、胱抑素 C指标在糖尿病早期肾损伤的临床诊断中能够作为监测指标，对临床判断有重要意义。  　　 [关键词 ] 糖尿病；早期肾损伤；尿微量白蛋白肌酐比值；胱抑素 C  　 [Objective] to explore and study the feasibility of using microalbumin / creatinine ratio and cystatin C test in early diabetic nephropathy. Methods the objective of this study was to select 80 diabetic patients who were treated in the Department of endocrinology of the hospital from September 2015 to November 2016. The clinical data were retrospectively analyzed and divided into 40 cases in each group according to the normal and normal urine albumin excretion rate. Urinary albumin creatinine ratio and serum cystatin were detected. Results the urine trace albumin creatinine ratio was (1.2 + 0.4) mg/mmoL and the ratio of microalbuminuria was (3.9 + 1.5) mg/mmoL in the group of urine microalbumin excretion group (3.9 + 1.5), and the difference between the two groups was statistically significant (P<0.05), and the urine microalbumin excreted normal group. The content of cystatin C was (0.7 + 0.3) mg/L and the content of cystatin C was (1.6 + 0.5) mg/L in the urine microalbumin excretion group, and the difference was statistically significant (P<0.05). Conclusion the ratio of urine trace albumin creatinine and cystatin C is closely related to urine microalbumin excretion. The use of urine trace albumin creatinine ratio and cystatin C index can be used as a monitoring index in the clinical diagnosis of early diabetic renal injury, which is of great significance for clinical judgment.