摘要
[摘要 ] 目的 研究应用小剂量胰岛素持续滴注治疗小儿糖尿病酮症酸中毒的临床效果。方法 该次纳入 2019年 1—12月收治的 72例糖尿病酮症酸中毒患儿展开研究，按照随机数字表法分为两组，在常规治疗的基础上，对照组 36例采用常规剂量胰岛素治疗，观察组 36例采用小剂量胰岛素持续滴注治疗。将两组的临床相关指标、临床效果、住院时间、低血糖发生率进行比对。结果 观察组糖尿病酮症酸中毒患儿的尿酮体转阴时间、临床症状消失时间及住院时间短于对照组，血糖下降速度慢于对照组，空腹血糖水平、餐后 2 h血糖水平、低血糖发生率均低于对照组，临床总有效率高于对照组，差异有统计学意义（ P<0.05）。结论 对糖尿病酮症酸中毒患儿采用小剂量胰岛素持续滴注治疗能够起到平稳降糖、改善临床症状的作用，还可减少低血糖的发生，具有较高的安全性。
[关键词 ] 小儿糖尿病酮症酸中毒 ;小剂量胰岛素 ;滴注
[Abstract] Objective To study the clinical effect of continuous infusion of low-dose insulin in the treatment of diabetic ketoacidosis in children. Methods 72 children with diabetic ketoacidosis admitted from January to December 2019 were enrolled in the study, and they were divided into two groups according to the random number table method. On the basis of conventional treatment, 36 cases in the control group were treated with conventional dose of insulin, and 36 cases in the observation group were treated with continuous infusion of low-dose insulin. The clinical related indexes, clinical effects, length of stay and incidence of hypoglycemia were compared between the two groups. Results the urine ketone body negative turning time, clinical symptoms disappearance time and hospitalization time of the observation group were shorter than those of the control group, the blood glucose decreased slower than the control group, the fasting blood glucose level, 2 h postprandial blood glucose level, hypoglycemia incidence rate of the observation group were lower than those of the control group, the clinical total effective rate was higher than that of the control group, the difference was statistically significant (P < 0.05). Conclusion continuous infusion of low-dose insulin in children with diabetic ketoacidosis can play a stable role in reducing blood sugar, improving clinical symptoms, and reducing the incidence of hypoglycemia, with high safety.
出版日期
2020年09月22日（中国期刊网平台首次上网日期，不代表论文的发表时间）
