摘要
Thecodontableforthecanonicalgeneticcodecanberearrangedinsuchawaythatthecodeisdividedintofourquartersandtwohalvesaccordingtothevari-abilityoftheirGCandpurinecontents,respectively.Forprokaryoticgenomes,whenthegenomicGCcontentincreases,theiraminoacidcontentstendtoberestrictedtotheGC-richquarterandthepurine-contentinsensitivehalf,whereallcodonsarefourfolddegenerateandrelativelymutation-tolerant.Conversely,whenthegenomicGCcontentdecreases,mostofthecodonsretracttotheAU-richquarterandthepurine-contentsensitivehalf;mostofthecodonsnotonlyremainencodingphysicochemicallydiversifiedaminoacidsbutalsovarywhentransversion(betweenpurineandpyrimidine)happens.Aminoacidswithsixfold-degeneratecodonsaredistributedintoallfourquartersandacrossthetwohalves;theirfourfold-degeneratecodonsareallpartitionedintothepurine-insensitivehalfinfavoriteofrobustnessagainstmutations.Thefeaturesmanifestedinthere-arrangedcodontableexplainmostoftheintrinsicrelationshipbetweenproteincodingsequences(theinformationalcontent)andaminoacidcompositions(thefunctionalcontent).Therenovatedcodontableisusefulinpredictingabundantaminoacidsandpositioningtheaminoacidswithrelatedordistinctphysicochem-icalproperties.
出版日期
2007年01月11日（中国期刊网平台首次上网日期，不代表论文的发表时间）
