摘要
BACKGROUND:Traditionalsubhibernationtherapymayeasilycausecomplications,suchasrespiratorydepressionandhyportensionbecauseofapplicationofchlorpromazinehydrochlorideandpromethazineinalargedosage.OBJECTIVE:Toobservetherapeuticeffectofmodifiedsubhibernationtherapy(alterativeapplicationoffiveanticonvulsantsaccordingtothehalflife)onstatusepilepticusinchildrenwithsevereviralencephalitis(VE).DESIGN:Contrastobservation.SETTING:DepartmentofPediatrics,theFirstHospitalofJilinUniversity.PARTICIPANTS:Theparticipantsinpresentstudywere96patientswithsevereviralencephalitisincluding52boysand44girlswhoreceivedtreatmentintheDepartmentofPediatrics,theFirstHospitalofJilinUniversityfromFebruary2000toMarch2006.AllchildrenmetthediagnosticcriteriaofZhufutongPracticePediatrics(theseventhedition).Twoweeksago,theyevergotupperrespiratoryinfectionorenteronitisandsoonbeforetheonset,spiritabnormal,behaviordisorder,limbsactdisorder,vomit,headache,convulsion,nervoussystemmasculinesignssuchaslimbsactdisord,autonomicnervedamagemanifestation,brainnervepalsy,dysreflexia,meningealirritationsign,cerebrospinalfluidandelectroencephalography(EEG)abnormity.Allparentsprovidedtheconfirmedconsent.Thepatientswererandomlydividedintocontrolgroup(n=40)andexperimentalgroup(n=56).METHODS:Patientsinthecontrolgroupreceivedanticonvulsion,icecompressandroutinetreatment.Theconvulsionwastreatedwithfivedrugs:0.5mg/kgwinterminandphenergan,respectively,100g/Lchlorpromazinehydrochloride(0.5mL/kg),5mg/kgluminal,0.3mg/kgansiolin.Whenconvulsionattacked,thosefivedrugsweregivenalternatively;however,thosewerenotgiveniftheconvulsiondidnotattack.Childrenintheexperimentalgroupweretreatedwithimprovedsubhibernationtherapybasedonroutinetreatment.Thedosagesofanticonvulsantswereasthesameasthoseinthecontrolgroup.Bas
出版日期
2007年09月19日（中国期刊网平台首次上网日期，不代表论文的发表时间）
