简介：摘要：文旅型特色小镇是植入了文化、旅游特色的小镇，属于当下新型的一种经济体，受到了各地的普遍欢迎，并在最近几年得到了极大的发展。文旅型特色小镇往往具备其独有的文化风俗和人文景观，这是文旅型特色小镇吸引游客的前来的重要前提，而其公共空间景观设计则重在对这种文化、旅游特色进行表达，是文旅型特色小镇规划过程中的一项重要内容，必须要给予足够的重视。本文就文旅型特色小镇公共空间景观设计进行了深入的探讨与分析，希望能够为一些文旅特色小镇的规划提供一定的参考价值。

简介：摘要：随着我国居民生活水平的提升，近些年来旅游行业的发展也十分迅速，从往常的入境旅游时期逐渐转变为国内旅游、出入境旅游共同发展时期，特别在21世纪后，我国旅游行业的规模扩大速度极为迅速，截止到目前为止，我国已然步入了旅游大国，据不完全统计，尤其在近几年我国出境旅游人数与国内旅游人数获得了世界首位。从国家角度触发，我国需要从旅游大国逐渐转变为旅游强国，在旅游业不断发展中，应为其注入更多的内涵，并与当地特有的文化素养进行融合，通过文旅的方式提升我国旅游的整体质量，并以此来推动乡村生态旅游的可持续性发展。本文便对其进行了简单阐述，仅供参考。                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  

简介：【摘要】目的从细胞生物学角度理解生物学宽度及其在口腔修复教学中的应用，期待能够为牙体缺损患者的诊断提供理论借鉴与实践指导。生物学宽度（Biologic Width）是指从龈沟底与牙槽嵴顶之间的恒定距离，结合上皮附着与结缔组织附着均为抵御细菌侵袭的重要屏障，一旦此屏障结构遭受破坏，细菌便会侵入机体造成局部的炎症反应，再有生物学宽度的屏障作用是由细胞学基础所决定。

简介：以“大规模协作”为特性的新经济模式一维基经济的出现，在全球范围内掀起一场创新风暴。这对身处其中的公司和个人来说都是一个全新挑战。在维基经济环境下，国际贸易也需创新，不仅是方式上，思想上更要真正开放，做好企业内部信息化，让从员工到合伙人、股东，再到顾客，都参与到企业的创新活动中来，集众人之长，提高效率，优化业绩，以期在越发严峻的国际竞争中成长发展。

简介：摘要目的了解深圳市2018年登革热疫情的流行病学特征和流行毒株的基因分型。方法采用描述性流行病学方法分析2018年深圳市登革热疫情，采集患者血液标本，采用胶体金免疫层析法检测血清特异性IgM、IgG抗体，采用实时荧光定量聚合酶链反应进行病原学检测和基因型别鉴定。采用反转录聚合酶链反应扩增登革病毒E基因序列，与不同国家和地区的登革热流行毒株进行同源性比较和进化树分析。结果2018年1月1日至12月31日，深圳市累计报告登革热234例，发病率为1.87/10万，本地病例144例(61.54%)，输入病例90例(38.46%)，以东南亚国家及深圳市周边城市输入为主。发病时间集中在8月至11月，共202例(86.32%)。以20～50岁中青年患者为主(195例，83.33%)。登革病毒1型(dengue virus type 1，DENV-1)占86.01%(166/193)，登革病毒2型(dengue virus type 2，DENV-2)占10.36%(20/193)，登革病毒3型占2.59%(5/193)，登革病毒4型占1.04%(2/193)，且本地病例均为DENV-1感染。24株DENV-1毒株与HAWAII45毒株E基因核苷酸同源性为93.0%～94.6%，氨基酸同源性为96.6%～97.2%。其中23株为基因Ⅰ亚型；1株为基因Ⅳ亚型，为深圳市首次报道的输入性病例。6株DENV-2毒株与国际标准株NGC株E基因核苷酸同源性为93.1%～93.9%，氨基酸同源性为97.0%～97.8%。其中2株为Cosmopolitan亚型；4株为Asian Ⅰ亚型，为深圳市首次报道。结论2018年深圳市登革热流行具有本地传播与输入传播并存的特点，主要流行为DENV-1，推测主要流行株由东南亚国家及深圳市周边城市输入，应加强关注出现地方性登革热流行的趋势。

简介：摘要：在建筑工程项目开展阶段中，设计作为项目的先决条件，设计效果的高低直接影响到项目的正常开展。就目前现状来看，在建筑工程设计时还存在一些问题，影响到了各项工作的开展。因此，本文结合实际，在分析建筑工程设计优化意义的基础上，对建筑工程设计存在的问题进行探讨，同时提出相关的设计措施。

简介：摘要目的总结分析SLCO2A1基因相关慢性肠病（CEAS）的临床特点及遗传学特征。方法回顾性分析2012年1月至2019年12月北京协和医院收治的5例CEAS的病例，分析其临床表现、实验室检查、影像学及内镜检查、治疗转归以及家系特点和基因检测结果。结果5例患者均为男性，胃肠道症状在青春期后出现。主要表现为腹痛、腹泻、间歇性黑便或便血、不全肠梗阻，以及贫血、低白蛋白血症、低钾血症。除食管外的全胃肠道均可受累，以胃及回肠为最常见。小肠病变特征为多发浅溃疡并肠腔狭窄，累及黏膜层及黏膜下层。5例患者均伴发原发性肥厚性骨关节病，1例伴发骨髓纤维化及胸导管发育异常。基因检测提示5例患者均为SLCO2A1基因纯合突变或复合杂合突变。炎症性肠病的常规治疗方法及COX-2抑制剂对该病无效。结论CEAS是一种可广泛累及胃肠道的常染色体隐性遗传病，可伴发皮肤及骨骼受累，目前尚无特效治疗药物，临床上需注意与其他炎症性胃肠道疾病相鉴别。

简介：摘要随着我国城市建设的力度不断加大，城市规划设计也得到了一定程度的发展。然而，城市建设中，必须从城市长期发展的角度出发进行合理的规划设计。而地域性对城市规划设计的影响是不容忽视的。基于此，本文首先对城市进行规划设计时应当考虑的地域因素进行了概述，详细探讨了城市规划设计中的地域性设计要点，旨在实现城市环境与自然环境的和谐共处。

简介：摘要：在小学语文教学中想要让整个课程教学工作的开展变得更有成效，需要加快课程教学评价体系的构建。新课标中强调要逐步建立主体多元、方式多样、素养导向的语文课程评价体系，坚持以评促学、以评促教，将评价贯穿语文课程教与学的全过程。

简介：在现代设计素描创作中,很多作品都逐渐远离自然生活,不能真正反映人的内心深处最真实的想法。为此,笔者希望在对设计素描的基础形态进行研究之外,还以一种新鲜的感官感知物象外表呈现的形态,从多视点多角度近距离地表现物象。深入地观察与感受所描绘物象的生命形态表象,摆脱传统观念以及思维训练的束缚,再选择适当的素描媒介与技术,做到尽可能地接近自己眼中所看到的物象。

简介：摘要：如今经济发展得越来越快和工业水平也在不断提高，我国石油的使用量也在逐年上升。石油是我国经济发展的能源支柱，是属于不可以再生的资源。要提高石油的利用率就要把管道建设得十分合理，而如何提高石油化工厂工艺管道设计的标准如今是重要的课题。工业要发展就不可能离开石油，所以提高石油化工厂工艺管道的设计就有这重要的现实意义。本文主要是对石油化工厂工艺管道的设计的问题进行分析，来供相关的设计者参考。

简介：摘要风景园林规划设计是以传统与现代的园林作为基础，紧密结合城市发展，从而促进风景园林建设发展。为了充分发挥其作用，本文阐述了风景园林规划设计的基本要求，对风景园林规划设计及其注意事项进行了简要分析。

简介：摘要：随着全球能源危机的愈发严峻和环境保护意识的增强，节能绿色建筑逐渐成为建筑行业的主流发展方向。建筑施工图作为建筑设计的重要组成部分，其设计质量对建筑物的节能环保性能起着至关重要的作用。在建筑设计中更好地体现节能绿色理念，提出与促进实际建筑工程应用相关的建设性方法，以期能够更好地促进建筑行业朝着节能环保、可持续发展方向迈进。

简介：摘要生态建设作为一个新生事物，值得探讨的问题还很多，今后的研究和探索道路还很漫长而且艰难，可持续发展将成为一种趋势。生态建筑理论的发展将导致建筑科技的内容的不断发展，必将推动整个建筑行业的发展。

简介：随着时代的进步，我们可以发现一个好的平面广告都有着一个好的图形设计，本文通过对图形创意思路的研究，意在能创造出更多、更好的平面广告。

简介：摘要基于胜任力的医学教育已形成全球趋势，对住院医师培训教学设计提出了更高要求。传统的课程设置已经不能满足基于胜任力的培养目标，其存在缺少课程设计层面教学理论支持等问题。课程设计作为住院医师培训的重要内容，对培养质量产生重要影响。依托六步法课程设计理论，将理论与实践相融合，形成基于理论指导的课程设计。通过反馈评价，对现行课程设计持续改进，以期达到基于住院医师岗位胜任力的培养目标。历经5年的探索，课程改革初具成效，本研究希望作为住培基地教学改革经验进行介绍推广，为同行提供参考与借鉴。