简介：Anewdynamicmodelforcell-deformation-inducedadenosinetriphosphate(ATP)releasefromvascularendothelialcells(VECs)isproposedinthispapertoquantifytherelationshipbetweentheATPconcentrationatthesurfaceofVECsandbloodflow-inducedshearstress.ThesimulationresultsdemonstratethatATPconcentrationatthesurfaceofVECspredictedbytheproposednewdynamicmodelismoreconsistentwiththeexperimentalobservationsthanthosebytheexistingstaticanddynamicmodels.Furthermore,itisthefirsttimethataproportional-integral-derivative(PID)feedbackcontrollerisappliedtomodulateextracellularATPconcentration.ThreetypesofdesiredATPconcentrationprofilesincludingconstant,squarewaveandsinusoidareobtainedbyregulatingthewallshearstressunderthisPIDcontrol.ThesystematicmethodologyutilizedinthispapertomodelandcontrolATPreleasefromVECsviaadjustingexternalstimulusopensupanewscenariowherequantitativeinvestigationsintotheunderlyingmechanismsformanybiochemicalphenomenacanbecarriedoutforthesakeofcontrollingspecificcellularevents.
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