简介：AIM:Tocomparetheconjunctivalepithelialtoxicitiesofthreenewer-generationfluoroquinoloneswithoutpreservatives.·METHODS:Inaprospective,randomized,doubleblindcomparativestudy,47eyesof47patientswithaprimarypterygiumwereenrolled,anddividedrandomlyintothreegroups(levofloxacin0.5%,gatifloxacin0.3%,andmoxifloxacin0.5%).Afterpterygiumsurgerywiththesameconjunctivalautografttechnique,eachpatientmaintainedaregimenwitharandomlyassignedfluoroquinoloneeyedrop.Patientswereexaminedeveryotherdayaftersurgeryuntiltheepitheliumhadcompletelyhealed.Photosweretakenandusedtomeasuretheareaofresidualepithelialdefects.Conjunctivalhealingtimeandspeed(initialdefectarea/healingtime(mm~2/d)comparedineachgroupusingKruskal-Wallistests.·RESULTS:Therewerenosignificantdifferencesinmeanage,gender,andconjunctivaldefectsizeofthedonorsitebetweenthesegroups.However,themeanofconjunctivalhealingtimeandspeedwerestatisticallydifferentineachgroup.Themeanofconjunctivalepithelialhealingtimewas8.93±2.69d(levofloxacingroup),10.31±2.96d(gatifloxacingroup),and13.50±4.10d(moxifloxacingroup),P=0.006.Themeanconjuctivalepithelialhealingspeedwas6.18±1.39mm~2/d(levofloxacingroup),5.52±1.68mm~2/d(gatifloxacingroup),and4.40±1.30mm~2/d(moxifloxacingroup),P=0.003.·CONCLUSION:Withouttheinfluenceofpreservatives,levofloxacinandgatifloxacinmightbelesstoxictotheregenerationofconjunctivalepithelialcellsandcauseafasterconjunctivalwoundhealingrelativetomoxifloxacin.