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1 个结果
  • 简介:Currentlytheclinicalmanagementofbreastcancerreliesonrelativelyfewprognostic/predictiveclinicalmarkers(estrogenreceptor,progesteronereceptor,HER2),basedonprimarytumorbiology.Circulatingbiomarkers,suchascirculatingtumorDNA(ctDNA)orcirculatingtumorcells(CTCs)mayenhanceourtreatmentoptionsbyfocusingontheverycellsthatarethedirectprecursorsofdistantmetastaticdisease,andprobablyinherentlydifferentthantheprimarytumor'sbiology.Toshiftthecurrentclinicalparadigm,assessingtumorbiologyinrealtimebymolecularlyprofilingCTCsorctDNAmayservetodiscovertherapeutictargets,detectminimalresidualdiseaseandpredictresponsetotreatment.Thisreviewservestoelucidatethedetection,characterization,andclinicalapplicationofCTCsandctDNAwiththegoalofprecisiontreatmentofbreastcancer.

  • 标签: 乳腺癌 肿瘤生物学 CTDNA 治疗方案 活检 液体