简介：ToscreenandidentifytheshortpeptideswithspecificbindingactivitytohumanCDS9andtodesigntheshort-peptideclampagainsttumorescape,thephagedisplaypeptidelibrarycontaining12peptideswasusedtoselectthehighlyexpressedspecificcoalescentpeptideofhumanCD59inCHOcells.Positivephageclonesobtainedafter5roundsofbiopanninganddetectedwithELISAwereobtained,inwhich8ofthemwithhighbindingactivitytohumanCD59weresequenced.The3sequencesthusobtainedshowedhighhomologywitheachandcertainhomologywithsequencewithhumanCD2(PubMed339HGAAENSISPSS),andallcontainedprimarystructureHXAXXXXXXPXX,ofwhichthissequencemaybethemimicconformationalepitopebindingtohumanCD59.Theseresultsinthepresentstudymaybehelpfultodesigntheshort-peptideclampagainsttheactivesitesofCD59ontumorescape.