简介:TheimmunomodulationofseveralChargedsyntheticpolymerscontainingphosphorusinthebackbonewasstudiedinvitrothroughexaminingtheirinhibitionorpromotioneffectontheproliferatioinofbothTandBlymphocytes,Itisfoundthatpolymersbasedonlongchainalkylesteroftyrosineexhibitimmunomodulativeactivity.NegativelychargedpolymersshowstimulativeactivityonLPS-inducedBlymphocytesproliferation.PositivelychargedpolymersexhibitinhibitoryactivityonbothConA-inducedTlymphocytesandLPS-inducedBlymplhyocytesproliferation.