简介：Mammaliantoothdevelopmentislargelydependentonsequentialandreciprocalepithelial-mesenchymalinteractions.Theseprocessesinvolveaseriesofinductiveandpermissiveinteractionsthatresultinthedetermination,differentiation,andorganizationofodontogenictissues.Multiplesignalingmolecules,includingBMPs,FGFs,Shh,andWntproteins,havebeenimplicatedinmediatingthesetissueinteractions.Transcriptionfactorsparticipateinepithelial-mesenchymalinteractionsvialinkingthesignalingloopsbetweentissuelayersbyrespondingtoinductivesignalsandregulatingtheexpressionofothersignalingmolecules.Adultstemcellsarehighlyplasticandmultipotent.Thesecellsincludingdentalpulpstemcellsandbonemarrowstromalcellscouldbereprogrammedintoodontogenicfateandparticipatedintoothformation.Recentprogressinthestudiesofmolecularbasisoftoothdevelopment,adultstemcellbiology,andregenerationwillprovidefundamentalknowledgefortherealizationofhumantoothregenerationinthenearfuture.
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