简介:目的探讨立体定向术治疗精神障碍的疗效。方法回顾性分析经立体定向术治疗的11例精神障碍病人的临床资料,其中难治性强迫症7例,抽动秽语综合征3例,双相情感障碍1例。分析手术前后耶鲁-布朗强迫量表(Y-BOCS)、汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)分值、脑白质纤维束变化及脑葡糖代谢情况。结果术后6个月病人的各量表分值较术前均明显下降(均P〈0.05),无严重并发症。大脑MRI弥散张量成像显示内囊前肢的横行纤维被毁损,大脑18F-FDGPET显示眶额皮质、运动区、运动前区、基底核、丘脑和边缘系统的高代谢区在术后明显降低。结论立体定向术是治疗难治性精神障碍的有效方法。
简介:IntroductionTheMedicalResearchFoundationistheMedicalResearchCouncil's(MRC)independentlymanagedcharity.Itreceivesfundsfromthegivingpublictosupportmedicalresearch,training,publicengagementanddisseminationofknowledge.Sinceitwasfirstestablishedin1920,theMRChasbeenabletoacceptcharitablebequests,endowmentsanddonationsfromthepublictocontributetowardsthecostsoftheresearchthatitundertakes.TheMRCregisteredthesecharitablefundswiththeCharityCommissioninthelate1960'sanditscharity-theMedicalResearchFoundation-hasbeensuccessfullysupportingmedicalresearchforover80years.Duringtheplanningphase,thedeliveryplanhelpsyoutoputyourinitialthoughtsandideasintoaformatthatisstraightforward.Thisoverviewwillenableyoutodeviseappropriatelearningstrategiesforyourtargetaudience,matchthelearningoutcomes,identifymaterialsandresources,andestimatetimeperiodsforlearningactivities,suchasdemonstrations,practiceandconsolidation,collaborationandquestiontime.