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简介：DearEditor,IamDr.SorayaMediero,fromDepartmentofOphthalmologyofLaPazUniversityHospital,Madrid,Spain.IwritetopresentacasereportofkeratoconusassociatedwithWilliams-Beurensyndrome(WBS).Toourknowledge,thisisthefourthreportofkeratoconusassociatedwithWBSandthe

简介：AIM:Toidentifyriskfactorsassociatedwithpost-cataractsurgeryendophthalmitis(PCE)intype2diabeticpatients.METHODS:Ahospital-basedretrospectivecase-controlstudywasconductedon194type2diabeticpatientsundergoingcataractsurgeryinRajavithiHospitalfromJanuary2007toDecember2015.FifteenpatientswithPCEwereincludedasthecasegroupand179patientswithoutPCEwereincludedasthecontrolgroup.PotentialfactorsassociatedwithPCEamongbothgroupsincludingdemographics,pre-operativecharacteristics,surgicalsettingsandcomplications,werestatisticallyanalyzedusingChi-squaretestingandalogisticregressionmodel.RESULTS:Withinthecasegroup,53%werefemalesandthemedianagewas68y.Univariateanalysisofpre-operativecharacteristics,surgicalsettingsandcomplicationsrevealedthatrecentpre-operativefastingplasmaglucose,insulintherapy,presenceofdiabeticretinopathy,andseverenon-proliferativeorproliferativediabeticretinopathyweresignificantlyassociatedwithPCE.Inamultivariateanalysisadjustingforbloodglucoselevel,insulintreatmentwastheonlysignificantfactorassociatedwithanincreasedriskofPCE(OR3.9,95%CI1.0-15.0,P=0.04)comparedtopatientswithoutinsulintreatment.Themostcommoncausativeorganismsweregram-positivebacteria(89%).Staphylococcusspeciesrepresentedthemostcommongroup(67%).Medianbestcorrectedvisualacuityat1-monthand3-monthfollow-upwasequalat0.7logMAR(20/100).CONCLUSION:Theauthorsidentifyinsulintreatmentastheonlyriskfactorassociatedwithendophthalmitisaftercataractsurgeryintype2diabeticpatients.Furtherstudieswithserumlevelsofpre-operativeglycatedhemoglobin(HbA1c)andpost-operativefastingplasmaglucoselevelareessentialtotrulydemonstratetheroleofperi-operativeglycemicmarkersasariskfactorforPCE.

简介：Wereportacaseofsyndromicgingivalfibromatosiswithnotableocularlesions,bilateralcongenitalcataracts,esotropia,andhighmyopiaofa21-year-oldmalepatientfromChina.Thepatientwasdiagnosedwithgingivalfibromatosisbasedonhismassivegingivalovergrowthandhistologicalfindingsthatwereconsistentwithgingivalfibromatosisthroughagingivalbiopsy.Lensopacityfeatureswerepresentedandphacoemulsificaionwithintraocularlens(IOL)implantationwasperformedtomanagethecataractsinbotheyes.Transmissionelectronicmicroscopywasusedtoinvestigatetheultrastructureoftheremovedlenstissue.Wealsoreviewtheliteratureongingivalfibromatosisandbrieflysummarizetheocularmanifestationsofthisraredisease.

简介：DearEditor,IamDr.XiuWang,fromTianjinMedicalUniversityEyeHospital,Tianjin,China.IwritetopresentonecasereportofPosner-Schlossmansyndrome(PSS)inducedlaserinsitukeratomileusis(LASIK)keratectasia.PSSisaconditioncharacterizedbyrecurrent,acuteattacksofmild,unilateral,non-granulomatous,anterioruveitis

简介：AIM:Toinvestigateandcomparethecytopathologicalandclinicaleffectsofamnioticmembranetransplantation(AMT)andoralmucosalmembranetransplantation(OMMT)insocketcontraction.METHODS:Twelvepatientswhocouldnotbefittedwithocularprosthesisduetosocketcontracturewereincludedinthisstudy.SevenpatientsunderwentAMTand5patientsunderwentOMMT.Thirteenpatientswhohadhealthysocketswereincludedascontrolgroup.Depthofinferiorfornix,degreeofinflammation,extentofthesocketcontractureandsocketvolumeweremeasuredinthepreoperativeperiodandatsixthandtwelfthweekspostoperatively.Impressioncytologyofconjunctivalfornicesandteartransforminggrowthfactorbeta-1(TGFβ1)levelsweredetermined.RESULTS:IntheAMTgroup,socketvolumeandlowerfornixdepthvaluesweresignificantlyhigher(P=0.030andP=0.004respectively)andinflammationlevelsandimpressioncytologystages(P=0.037andP=0.022respectively)weresignificantlylowerinpostoperativeperiodcomparedtopreoperativeperiod.IntheOMMTgroup,nostatisticaldifferenceswerefoundintermsofclinicalparameters,inflammationlevelsandimpressioncytologystagesofpreoperativeversuspostoperativevalues.PreoperativetearTGFβ1levelswerehigherinAMTandOMMTgroupscomparedtothecontrolgroup(25.5ng/mL,26.3ng/mLand21.7ng/mLrespectively).DecreasedtearTGFβ1levelswereobservedinboththeAMTandOMMTgroupspostoperatively(mediandecreasevalue=2.1ng/mLand2.7ng/mLrespectively).CONCLUSION:AMTisassociatedwithpostoperativeimprovementininferiorfornixdepth,socketvolume,inflammationandimpressioncytologylevelsandmaybeamoreproperalternativemethodthanOMMTinthemanagementofsocketcontracture.

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简介：AIM:Toreportthecytologyresultsof25-gaugetransconjunctival(25G-TSV)diagnosticvitrectomyincasessuspiciousforintraocularlymphoma(IOL),andcomparetheresultstothosereportedintheliterature.METHODS:Clinicalandcytopathologicalrecordsof18vitreousbiopsyspecimensobtainedvia25G-TSVdiagnosticvitrectomyin12patientssuspiciousforIOLwerereviewedretrospectively.Areviewoftheliteratureinregardstothediagnosticyieldsofvitreousspecimensobtainedvia25-gaugeand20-gaugediagnosticvitrectomyinsuspectedcasesofIOLwasperformed.RESULTS:Eighteeneyesfrom12patientswithclinicalsuspicionofIOLunderwentdiagnostic25G-TSV.ThecytopathologicalinvestigationsdemonstratedIOLin15eyes(83.3%).Vitreousanalysiswasnon-diagnosticin3eyes(16.7%).CONCLUSION:Twenty-five-gaugediagnosticvitrectomyyieldsadequatesampleforcytologicalevaluationofthevitreousincasessuspiciousforIOL.Thediagnosticresultsofthe25G-TSVinthecurrentstudyaresuperiortothosereportedfor20-gaugevitrectomybutequivalenttothosereportedfor25G-TSVinthepublishedliterature.

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简介：·AIM:Toobtainwideningofapotentiallyoccludableangle,inaccordingtoKanski’sindications,throughpreventiveNd:Yaglaseriridotomy.Theobservationalstudywasperformedbyusinggonioscopyfortheselectionandfollow-upof1165treatedeyesandexploitingShaffer-Etiennegonioscopicclassificationasaquality/quantitytestoftheanglerecession.·METHODS:BetweenSeptember2000andJuly2012,586patientswereselectedattheOutpatients’OphthalmologicalClinicofthePoliclinicoUmbertoIofRomeinordertoundergoNd:Yaglaseriridotomy.AGoldmanntypecontactlens,Q-switchedmode,2-3defocus,and7-9mJintensitywith2-3impulsedischargeswereusedforsurgery.·RESULTS:Fromasearlyasthefirstweek,awhole360°anglewideningwereevidentinthepatients,thusshowingthesuccessofNd:Yaglaseriridotomyinsolvingrelativepupilblock.Theangleremainednarrowby270°in14eyesonly,despiterepetitionsoffurthertreatmentwithlaseriridotomyinadifferentpartoftheiris,twicein10eyesandthreetimesin4eyes.·CONCLUSION:Nd:YaglaseriridotomyrevealeditselfasbeingasafeandeffectivetreatmentinwideningthosecriticalShaffer-Etiennegrade1and2potentiallyoccludableangles.

简介：AIM:ToinvestigatethepositiverateandtypesofcellsthatexpressEpstein-Barrvirus-encodedsmallRNAs(EBERs)andtodeterminethedistributionofEBER-expressingcellsinidiopathicorbitalinflammatorypseudotumor(IOIP)tissues.METHODS:Weretrospectivelyexamined40archivedparaffinspecimensfromtwoteachinghospitalsinSouthernChinabetweenJanuary2007andJanuary2015thatwerepathologicallydeterminedtoexhibitIOIP.Elevenconcurrentparaffinspecimensofthyroid-associatedophthalmopathy(TAO)composedthecontrolgroup.InsituhybridizationwasperformedtodetectEBERs.ImmunohistochemistrywasemployedtodetectCD3,CD20,Vimentin,andsmoothmuscleactin(SMA),andthepositiverate,typesofpositivecells,anddistributionandlocationofEBERswereevaluated.RESULTS:ThepositiveexpressionrateofEBERswas47.5%(19/40)intheIOIPgroup,whichwassignificantlyhigherthanthatintheTAOgroup[0(0/11),P=0.011].IntheIOIPgroup,thelymphocyteinfiltrativesubtype,fibroticsubtype,andmixedsubtypeexhibitedEBER-positiveratesof57.1%(12/21),12.5%(1/8),and54.5%(6/11),respectively,andnosignificantdifferenceswerefoundbetweenthesesubtypes(P=0.085).PositivesignalsofEBERsweremainlypresentinmedium-smalllymphocytesbetweenoraroundfolliclesandinthenucleiofactivatedimmunoblasts(14/19).CONCLUSION:Thepositiverate,types,anddistributionofEBER-expressingcellsinIOIPhavebeendocumented.ThesefindingsareconduciveforabetterunderstandingoftheunderlyingmechanismsofEpstein-BarrvirusinfectioninIOIPpathogenesis.

简介：AIM:Toevaluatetheeffectofreleasingtheorbicularisretainingligament(ORL)complexoftheteartroughcombinedwiththetransconjunctivalblepharoplastyinthesurgicalmanagementofteartroughdeformitycomparedwiththeeffectofblepharoplastyalone.METHODS:Aprospective,randomized(byclosedenvelopetechnique),controlledsurgicaltrialwhichincluded50patients(100eyes)withbilateralvisibleteartroughdeformityandlowereyelidfatbulging,wasdividedintotwogroupswhere25patients(50eyes)hadteartrough-ORLreleasewithblepharoplastyand25patients(50eyes)didn’t.Qualitativeandquantitativeassessmentsofteartroughdeformityweredoneat6mopostoperatively,achievinggrade0or1ofBarton’sclassificationwasconsideredasuccess.Standardizedphotographicdocumentationofeachpatientwasdonepreandpostoperatively,alsoassessmentofthepatients’satisfactionpostoperativelywasdoneandrankedasexcellent,verygood,goodorfair.RESULTS:Therewasstatisticallysignificantdifferencebetweenthetwogroupsintheoverallaestheticresultspostoperativelyregardingthequalitativeandquantitativeanalysisoftheteartroughdeformity,wherepatientswhohadteartrough-ORLcomplexreleasehadmoresuccessfuloutcomesthanthoseofthesecondgroup.CONCLUSION:ORLreleaseshouldbedoneinpatientswithteartroughdeformityinordertoreleasethetetheringeffectofthisligamentwhichcausestheprominenceofthenasojugalgroove.

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简介：AIMTo调查锰superoxidedismutase(MnSOD)的协会有糖尿病的retinopathy(医生)的Val16Ala多型性.METHODSPubMed，Embase，中国知识基础结构，和Wanfang数据库被寻找。分享的机会比率(ORs)和95%信心间隔(CI)被计算评估协会的力量。亚群，敏感，和累积分析被执行。出版偏爱也是analyzed.RESULTSEight研究在分享的分析被包括。MnSODVal16Ala多型性在主导的模型下面与医生的风险被联系(OR=0.66，95%CI=0.48-0.91，P<0.0001)，这结果被表明在累积分析相对稳定。没有重要出版偏爱被发现。这多型性也在主导的模型下面在白种人与医生的风险被联系(OR=0.64，95%CI=0.42-0.97，P=0.04，)并且在在后退的模型下面的亚洲人(OR=0.31，95%CI=0.11-0.88，P=0.03).CONCLUSIONThese调查结果建议MnSODVal16Ala多型性是为医生的一个风险因素，并且更多的注意竟然对这些危险性基因的搬运人被给予。