简介：Arachidonicacid-metabolizingenzyme5-lipoxygenase(5-LOX)producespro-inflammatorymediators:leukotrienes(includingcysteinylleukotrienes,CysLTs).5-LOXandCysLTsareinvolvedinthepathophysiologicalprocessafterbraininjury,andtheactionsofCysLTsaremediatedviaactivationoftheirreceptors,CysLT1andCysLT2.Wehaverecentlyreportedtheexpressionsof5-LOX,CysLT1andCysLT2inhumanbrainswithtraumaticinjuryandtumors,andshort-termneuroprotectiveeffectsofCys-LT1antagonistsinstrokemodelsofratsandmice.
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