论文查询检索-中国期刊网

简介：AIMToinvestigatetheexpressionchangeofα-synucleininthebrainofdifferentageAD-likean-imalmodelandtoexplorethepathologymechanismofα-synucleininneuraldegenerationandprotectiveeffectof2kindsofChinesecomponents.METHODSAgenerallyacceptedanimalmodelofAlzheimer'sdisease-APPV717Itransgenic(Tg)mousewasobservedfrom4to16monthold.TheTgmicewererandomlydividedintomodelgroup(4month,10monthand16monthold),Shen-wucapsulewiththedoseof0.4gand1.2g/kg/d,2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside(TSG),oneofeffectivecomponentsinPolygonummuhiflorum,atdoseof0.05,0.1and0.2g/kg/d.
标签：基因表达 Α-SYNUCLEIN 年龄不同 APP 转基因老鼠阿尔海默氏病

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