简介:为阐明β榄香烯的抗血小板作用,本文分别采用比浊法和放免法测定大鼠连续ip7dβ榄香烯乳6.25~12.5mg·kg-1·d-1后对血小板聚集、血浆ketoPGF1α和TXB2水平的影响。结果表明,本品分别使凝血酶、花生四烯酸和ADP诱导血小板最大聚集率下降38.3%~42.6%,14.7%~19.1%和7.2%~10.8%,血浆TXB2从88ng·L-1下降至72ng·L-1,ketoPGF1α从17.5ng·L-1增加至20.9ng·L-1。提示TXB2降低和ketoPGF1α值增加是其抑制血小板聚集的作用机制之一。
简介:Aims:TotaltriterpenoidfromPrunellavulgarisL.(TTP),knownasmedicinehad,hadapreventiveeffectagainsthepaticsteatosisinourpreviouswastoevaluatewhetherTTPcouldimproveliverfibrosisnismofactionofTTPonhepaticstellategrowthfactor(PDGF).atraditionalChinesestudy.Ourobjectiveinratsandtoinvestigatethemecha-cell(HSC)proliferationinducedbyplatelet-derivedgrowthfactor(PDGF).