简介:为预测和评价贵州普安泥堡金矿床的成矿潜力,采用原生晕地球化学方法对10460勘探线所控制的Ⅲ-1号矿体进行原生晕轴向分带特征研究。采集了该勘探线上6个钻孔矿体附近的构造蚀变岩石样品进行ICP-AES分析。通过对各元素进行相关性分析及因子分析,选取原生晕地球化学特征研究的指示元素为Au、As、Ag、Cu、Hg、Mo、Co、Cd、Sb。综合原生晕分带图及指示元素分带序列分析,判断Ⅲ-1矿体原生晕出现了明显的分带异常,其由浅部到深部总体表现为:前缘晕元素+尾晕元素—近矿晕—前缘晕元素+近矿晕元素+尾晕元素的元素异常分布序列,指示在深部存在一个或多个隐伏矿体,是造成元素异常叠加共存与轴向分带序列异常的原因。
简介:凌源-宁城盆地是松辽盆地外围南部众多具良好油气勘探前景的小盆地之一,为研究其中的油气资源情况,在牛营子地区部署和实施了油气地质调查井——牛D1井。该钻井揭示侏罗系海房沟组可能为研究区重要的烃源岩发育层系之一。系统采集了海房沟组岩心,对其进行了岩石热解、镜质体反射率、气相色谱-质谱等分析及有机地球化学研究。结果表明,海房沟组浅部多为好-很好烃源岩,而深部多为差烃源岩和非烃源岩,有机质类型均主要为Ⅱ_2和Ⅲ型;浅部烃源岩的三环萜烷、升藿烷和甾烷系列丰度较高,规则甾烷呈不对称"V字型";而深部烃源岩的三环萜烷、升藿烷和甾烷系列丰度较低,规则甾烷多呈"反L型"。综合认为海房沟组浅部具有相对较强的生烃潜力,但牛D1井海房沟组烃源岩的成熟度较低,建议今后加强对海房沟组烃源岩展布和成熟度平面分布特征的研究。
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简介:Cytarabine(1-β-D-arabinofuranosylcytosine,Ara-C),isolatedfromaCaribbeanspongespeciesTethyacrypta,isthefirstantitumordrugfromamarineresource.In1980,theUSFoodandDrugAdministrationapprovedthisdrugforthetreatmentofdifferenttypesofleukemia.Thisdrughasashortplasmahalf-life,lowstability,limitedbioavailability,andseveresideeffects.Toimprovestabilityandbioavailability,wesynthesizedninenovelderivativesbyblockingthecytarabinemetabolicsitesandimprovinglipophilicity.ThecLogPvaluesofthenewlysynthesizedcompoundswerecalculated.Allthesynthesizedcompoundsweremorelipophilicthancytarabine,resultinginmembranepermeabilityandbioavailabilityimprovement.TheantitumoractivitiesagainstleukemiacelllineHL-60wereevaluatedbyusingtheMTTassay.ThebioassayresultsrevealedthattheIC50valuesofcompounds5,8and9were0.080,0.090and0.057μmolL-1,respectively,whichwassimilarwiththatofcytarabine(0.056μmolL-1).Incomparison,compound4withaphosphategroupatO5’wasinactive.Becausephosphoesterbondsareeasilyhydrolyzedbyalkalinephosphataseandarecommonlyusedinproducingprodrugstrategies,compound4mightalsobemetabolizedinvivoandgeneratecompound3orevencytarabinethroughamulti-stepreaction.Thus,compound4mightbeapromisingcompoundtobedevelopedasaprodrug.
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简介:Amapoftheaverageatomicnumberoflunarrockandsoilcanbeusedtodifferentiatelithologyandsoiltypeonthelunarsurface.Thispaperestablishesalinearrelationshipbetweentheaverageatomicnumberoflunarrockorsoilandthefluxofpositionannihilationradiation(0.512-MeVgamma-ray)fromthelunarsurface.TherelationshipisconfirmedbyMonteCarlosimulationwithdatafromlunarrockorsoilsamplescollectedbyLuna(Russia)andApollo(USA)missions.AmapoftheaverageatomicnumberofthelunarrockandsoilonthelunarsurfacehasbeenderivedfromtheGamma-RaySpectrometerdatacollectedbyChang’e-1,anunmannedChineselunar-orbitingspacecraft.Inthemap,thehigheraverageatomicnumbers(ZA>12.5),whicharerelatedtodifferenttypesofbasalt,areinthemariaregion;thehighestZA(13.2)readingsareassociatedwithSinusAestuum.ThemiddleZA(~12.1)regions,intheshapeofirregularovalrings,areinWestOceanusProcellarumandMareFrigoris,whichseemstobeconsistentwiththedistributionofpotassium,rareearthelements,andphosphorusasauniquefeatureonthelunarsurface.Theloweraverageatomicnumbers(ZA<11.5)arefoundtobecorrelatedwiththeanorthositeonthefarsideoftheMoon.
简介:TheeffectsofBacillussubtilis2-1fromtheintestineofhealthyseacucumberonthegrowth,digestiveenzymeactivitiesandintestinalmicrobiotaofjuvenileseacucumber(Apostichopusjaponicus)weredeterminedinthepresentstudy.SeacucumberwasfedwithSargassumthunbergiipowdersupplementedwithB.subtilis2-1atdifferentconcentrationsvaryingamong0(control),105,107,and109CFUg-1for8weeks.ResultsshowedthatthegrowthperformanceandintestinalamylaseandtrypsinactivitiesweresignificantlyincreasedbydietaryB.subtilis2-1at109CFUg?1(P<0.05).However,dietaryB.subtilis2-1hadnosignificantinfluenceonthelipaseactivityinseacucumber(P>0.05).Thepolymerasechainreactiondenaturinggradientgelelectrophoresisand16SrRNAgenesequencinganalysisindicatedthatdietaryB.subtilis2-1at105and107CFUg-1inhibitedmostoftheProteobacteriaincludingthoseingenusVibrio.DietaryB.subtilis2-1at109CFUg-1notonlydecreasedtheabundanceandspeciesofgenusVibrio,butalsoincreasedtheintensityofgeneraPsychrobacterandBacillus.AspecificdosageofdietaryB.subtilis2-1couldincreasethegrowthandmodulatetheintestinalmicrobiotaofseacucumber;thusitmightbeanovelprobioticforkeepingthehealthofseacucumber.
简介:AbstractTheGartnerkofelboreholeisoneofthemostthoroughlystudiedanddescribedPermo-Triassicsectionsintheworld.Detailedbulkorganiccarbonisotopestudiesshowanegativebaseshiftfrom-24%0to-28%0intheLatestPermianwhichlattervaluepersistsintotheEarliestTriassicafterwhichitdecreasesslightlyto-26‰.Twostronglynegativepeaksof〉-38‰intheLatestPermianandalesserpeakof-31‰intheEarlyTriassicaretoonegativetobeduetoagreaterproportionofmorenegativeorganicmatterandmustbeduetoverynegativemethaneeffects.TheoverallchangetomorenegativevaluesacrosstheBulla/Teseroboundaryfitstherelativeriseinsealevelforthistransitionbasedonthefacieschanges.ApositiveshiftinorganiccarbonisotopevaluesattheLatePermianEventHorizonmaybeduetoanincreaseinland-derivedorganicdetritusatthislevel-afeatureshownbyallTethyanPermo-Triassicboundarysectionsthoughtheseothersectionsdonothavethesamevalues.Carbonatecarbonisotopetrendsaresimilarinallsectionsdroppingby2-3unitsacrossthePermo-Triassicboundary.Gart-nerkofelcarbonateoxygenvaluesaresurprisingly,con-sideringtheubiquitousdolomitization,compatiblewithvalueselsewhereandindicatereasonabletropicaltemper-aturesof60~CintheLatestPermiansabkhasto20-40℃intheoverlyingmarinetransitionbeds.Increasedland-derivedinputattheLatePermianEventHorizonmaybeduetooffshoretransportbytsunamiswhosedepositshavebeenrecognizedinIndiaatthislevel.
简介:乡镇级气象灾害风险评估,是政府主导、部门联动、社会参与防御和应对气象灾害中最基础的一环,对基层灾害风险管理和灾害防御具有直接的指导意义。然而,乡镇行政单元往往空间区域较小,风险空间差异的反映需要有高精度的致灾因子、承灾体和灾情数据来支撑,而现阶段较为匮乏。为此,本研究拟通过阈值筛选、权重赋值及空间插值等地学统计方法,尝试建立一套在当前数据条件基础上,大致正确反映乡镇级别气象灾害风险空间格局的方法,并以浙江省永嘉县为例,对台风、暴雨、雷电、低温灾害进行了乡镇气象灾害风险评估,以期为各部门切实进行不同灾种的灾害防备和增强基层群众气象灾害风险防御行动提供科学依据。
简介:基于中国陆地生态系统价值当量换算法,结合遥感和GIS技术分析了博州1992—2013年的生态服务价值,并分析了生态服务价值变化的驱动因素。结果表明:1)近22年博州生态服务价值呈先减后增趋势,在空间上的分布特征主要表现为东北部价值高、西部价值低,极低值位于市中心区域,极高值主要位于艾比湖湿地和夏尔希里等自然保护区域;2)土地利用/覆被变化直接影响着各土地利用/覆被类型服务价值对总生态服务价值的贡献,气候因素对生态服务价值的影响呈现出显著的空间差异,经济发展、农业的现代化和政府政策的实施在一定程度上可以促进生态服务价值的增长,而牧民生产经营活动则在一定程度上对生态服务价值的发展起到负作用。