简介:Necrotizingpancreatitisisanuncommonyetseriouscomplicationofacutepancreatitiswithmortalityratesreportedupto15%thatreach30%incaseofinfection.Traditionallyopensurgicaldebridementwastheonlytoolinourdisposaltomanagethisseriousclinicalentity.Thisapproachishoweverassociatedwithpooroutcomes.Managementhasnowshiftedawayfromopensurgicaldebridementtoamoreconservativemanagementandminimallyinvasiveapproaches.Contemporaryapproachtopatientswithnecrotizingpancreatitisand/orinfectiouspancreatitisissummarizedinthe3Ds:Delay,DrainandDebride.Patientscanbemanagedintheintensivecareunitandanyinterventionshouldbedelayed.Percutaneousdrainagecanbeutilizedfirstandearlyinthecourseofthedisease,followedbyendoscopicdrainageorvideoassistedretroperitoneoscopicdrainageifnecrosectomyisdeemednecessary.Opensurgeryisnowlessfrequentlyperformedandshouldbereservedforcasesrefractorytoanyotherapproach.Themanagementofnecrotizingpancreatitisthereforerequiresamultidisciplinarydynamicmodelofapproachratherthanbeingasurgicaldisease.
简介:摘要目的通过比较双硫仑反应不同的治疗方法,论证纳洛酮在双硫仑反应治疗中的有效性。方法71例双硫仑反应患者,随机分成对照组与实验组,对照组给予脱敏,补液等常规治疗,实验组额外加用纳洛酮,统计两组症状消失时间,用t检验比较两组症状消失时间是否存在差异。结果与对照组比较,纳洛酮组症状消失时间明显缩短,具有统计学意义(P<0.01)。结论纳洛酮治疗双硫仑反应行之有效,改善患者症状,缩短症状消失时间,值得推广应用。
简介:Chronicpancreatitisisanongoingdiseasecharacterizedbypersistentinflammationofpancreatictissues.Withdiseaseprogression,patientswithchronicpancreatitismaydeveloptroublesomecomplicationsinadditiontoexocrineandendocrinepancreaticfunctionalloss.Amongthem,apseudoaneurysm,mainlyinducedbydigestiveenzymeerosionofvesselsinproximitytothepancreas,isarareandlife-threateningcomplicationifbleedingofthepseudoaneurysmoccurs.Atpresent,noprospectiverandomizedtrialshaveinvestigatedthetherapeuticstrategyforthisrarebutcriticalsituation.Theroleofarterialembolization,thetimingofsurgicalinterventionandevensurgicalproceduresarestillcontroversial.Inthisreview,wesuggestthatdynamicabdominalcomputedtomographyandangiographyshouldbeperformedfirsttolocalizethebleedersandtoevaluatetheassociatedcomplicationssuchaspseudocystformation,followedbyarterialembolizationtostopthebleedingandtoachieveearlystabilizationofthepatient’scondition.Withadvancesandimprovementsinendoscopicdevicesandtechniques,therapeuticendoscopyforpancreaticpseudocystsistechnicallyfeasible,safeandeffective.Surgicalinterventionisrecommendedforableedingpseudoaneurysminpatientswithchronicpancreatitiswhoareinanunstablecondition,forthoseinwhomarterialembolizationofthebleedingpseudoaneurysmfails,andwhenendoscopicmanagementofthepseudocystisunsuccessful.Ifableedingpseudoaneurysmislocatedoverthetailofthepancreas,resectionisapreferentialprocedure,whereasifthelesionissituatedovertheheadorbodyofthepancreas,relativelyconservativesurgicalproceduresarerecommended.
简介:ObjectiveToreportoutcomesofnonsurgicalandsurgicalmanagementofMenière’sdiseaseatBeijingTiantanHospital.MethodsPatientswithMenière’sdiseasewerecategorizedintogroupsbasedonhearingandqualityoflife.Individualizedmanagementwasprovided,includinglifestylemodification,drugtherapies,endolymphaticsacdecompressionandlabyrinthectomy.Treatmentoutcomeswereevaluatedduringupto24monthsfollowup.ResultsEightysevenpatientsunderwentlifestylemodificationanddrugtherapies.ThevertigocontrolrateofGradeAandBwas76.9%and83.8%respectively.Sixpatientsreceivedsurgicalmanagement,includingendolymphaticsacdecompression(n=5)andlabyrinthectomy(n=1).Forthesepatients,thevertigocontrolrateofGradeAandBwas80%and100%,respectively.ConcluIsionsManagementofMenière’sdiseasedependsonseveralfactors,i.e.severitiesofvertigoandhearingloss,qualityoflife,surgicalcontraindicationsandpatientsubjectivedesire.Thetreatmentisdrugtherapiesforthemajorityofpatients,aswellaslifestylemodification.Surgicalindicationsarerareandtheleastinvasiveproceduresshouldbeconsideredfirst.Theresultsofsurgeryaregenerallysatisfying.
简介:摘要目的研究和分析EV71型手足口病患儿在临床治疗中的有效护理方式和效果。方法随机择取46例EV71型手足口病患儿,将他们平均分成对照组和观察组两组。分别给予其常规护理和综合护理,并就两组患儿的临床护理治疗效果进行比较、统计和分析。结果观察组患儿的临床护理疗效(91.30%)和护理满意度(100.0%)明显高于对照组患儿(78.26%,73.91%),组间比较均具有极大的差异性,存在统计学意义(P<0.05)。结论选择综合护理干预对EV71型手足口病患儿进行临床干预治疗,能够有效的提高临床治疗效果,缓解患儿临床症状,提高家属满意度,因此,应该给予临床上的广泛应用和推广。
简介:Advancedgastriccancer(GC)hasbeenrecognizedaslethaldiseasewhenperitonealmetastases(PM)occurred.ThereisnostandardtreatmentforadvancedGCwithPM.Until1980s,thetherapeuticarenaforthesepatientshadremainedstagnant,withnotherapeuticapproachhavingshownasurvivalgaininGCwithPM.However,cytoreductivesurgery(CRS)withperitonectomyproceduresandintraperitonealchemotherapy(IPC)promisingnewcombinedtherapeuticapproachtoachievediseasecontrolforGCwithPM.TherecentpublicationschangedtheGCwithPMtreatmentlandscapebyprovidinganevidencethatCRSandIPCledtoprolongationinoverallsurvival(OS).ThisreviewwillprovideanoverviewoftheevolvingroleofCRSandIPCinthemanagementofadvancedGCwithPMinthecurrentera.
简介:目的:研究免疫层析法(ICA)和酶联免疫吸附法(ELISA)检测肠道病毒71型(EV71)IgM抗体在手足口病诊断中的意义。方法采集135例手足口病确诊患儿和44例排除手足口病诊断的患儿血清标本,采用ICA及ELISA检测EV71IgM抗体。结果135例手足口病患儿,ICA、ELISA检测EV71IgM抗体阳性率分别为21.48%(29/135)和20.74%(27/135);44例非手足口病患儿,ICA、ELISA检测EV71IgM抗体阳性率均为0.00%(0/44)。结论ICA或ELISA检测EV71IgM抗体阳性者均可确诊为手足口病,但检测结果为阴性者,不能排除手足口病的可能性,应结合临床表现进行诊断。
简介:摘要目的为减少围产期缺氧所致新生儿并发症,减少各种残疾的发生。方法将2012年-2014年在我院住院的因围产期缺氧导致各种并发症新生儿71例诊疗情况进行回顾性分析。结果围产期缺氧致新生儿并发症中新生儿高胆红素血症及心肌损害最多,而以缺氧缺血性脑损伤危害最大。结论加强围产期保健,早期发现、早期干预围产期缺氧可降低新生儿的并发症、后遗症的发生率及新生儿死亡率。
简介:摘要目的探讨EV71感染所致手足口病患儿外周血淋巴细胞亚群的变化及临床意义。方法将88例经粪便RT-PCR试验检测为EV71感染的手足口病患儿分为三组并收集血液标本,普通型24例,重症型21例,危重型43例。采用流式细胞术检测外周血CD3+T细胞、CD4+T细胞、CD8+T细胞、CD56+T细胞、CD19+T细胞表达。所有数据采用STATA软件进行统计。结果危重型患儿外周血CD3+T细胞比例为50.70±9.42%,重型组患儿外周血CD3+T细胞比例为50.43±10.89%,普通型组患儿外周血CD3+T细胞比例为55.57±9.76%,重型和危重型患儿外周血细胞CD3+T细胞比例较普通型组降低,但差别无显著统计学意义。(P>0.05)。危重型患儿外周血中CD4+T细胞比例为24.87±7.78%,重型组患儿外周血CD4+T细胞比例为25.06±7.87%,普通型患儿外周血CD4+细胞比例30.18±7.18%,危重型组和重型组患儿外周血CD4+T细胞比例较普通型组降低,且随病情加重而减低。三组患儿CD8+、CD56+、CD19+T细胞比例无显著差异(P>0.05)。结论T淋巴细胞减少可能是EV71感染手足口病患儿并发重症和危重症的重要因素之一。
简介:TheTenthInternationalGastricCancerCongress(IGCC)washeldinVerona,Italy,fromJune19to22,2013.Themeetingenclosedvariousaspectsofstomachtumormanagement,includingbothtightlyclinicalapproaches,andtopicsmorerelatedtobasicresearch.Moreover,anoverviewongastrointestinalstromaltumorswasprovidedtoo,althoughherenotdiscussed.Herewewilldiscusssometopicsrelatedtomolecularbiologyofgastriccancer(GC),inherenttoprognostic,diagnosticandtherapeutictoolsshownattheconference.Resultsaboutwellknownsubjects,suchasE-cadherinlossofexpression/function,werepresented.Theyrevealedthatothermutationsofthegenewereidentified,showingacontinuousresearchtoimprovediagnosisandprognosisofstomachtumor.Simultaneously,newpossiblemolecularmarkerswithanestablishedroleforotherneoplasms,werediscussed,suchasmesothelin,stomatin-likeprotein2andNotch-1.Hence,awideoverviewincludingbotholdandnewdiagnostic/prognostictoolswasoffered.GreatattentionwasalsodedicatedtopossibledrugstobeusedagainstGC.Theyincludedmonoclonalantibodies,suchasMS57-2.1,drugsusedinotherpathologies,suchasmaraviroc,andnaturalextractsfromplantssuchasbiflorin.WewouldliketocontributetosummarizethemostimpressivestudiespresentedattheIGCC,concerningnovelfindingsaboutmolecularbiologyofgastriccancer.Althoughfurtherinvestigationswillbenecessary,itcanbeinferredthatmoreandmoretoolsweredeveloped,soastobetterfacestomachneoplasms.
简介:摘要目的采用ELISA法和荧光RT-PCR法分别检测手足口病EV71,比较两种方法的差异性。方法严格按ELISA法和荧光RT-PCR法的操作要求分别检测221例临床标本手足口病EV71。结果两种方法检测EV71的结果221份标本,ELISA法阳性51例,荧光RT-PCR法阳性55例。两种方法比较差异无统计学意义(P>0.05)。结论本实验结果表明,两种方法的灵敏度分别为28.2%和30.4%,特异性均为100%,两者比较差异无统计学意义(P>0.05)。