简介:为了从期刊文献的学科属性实现族性检索,为文章的分类统计创造条件,本刊2005起均对具有文献标识码的文章采用《中国图书馆分类法》(第四版)进行分类后。标识分类号文章一般标识1个分类号,多个主题的文章可标识2个或3个分类号;主分类号排在第一位,多个分类号之间应以分号分隔。希望有条件查询的作者在来稿时自行标明中图分类号。
简介:为研究乳宁Ⅱ号方(主药:生黄芪、太子参、当归、枸杞、天门冬、淫羊藿、鹿角片、米仁、莪术、八月札、露蜂房、山慈菇)的作用机理,将体外培养的MA891细胞接种在小鼠右腋皮下,然后将小鼠分为生理盐水组(A)、环磷酰胺(CTX)组(B)、CTX+乳宁Ⅱ号组(C)、乳宁Ⅱ号组(D)、扶正组(E)、祛邪组(F).各组小鼠分别给予相当于临床成人用量2倍的上述各种药物治疗.21天后处死小鼠,运用免疫组化和PT-PCR方法观察各组小鼠乳腺癌血管内皮生长因子(VEGF)及其受体f1K-1蛋白和mRNA的变化.结果:B、D、C、E、F组都能减少VEGF、f1K-1蛋白和mRNA的表达,其中C组效果最好,D组次之.提示:抑制VEGF、f1K-1的表达,从而抑制肿瘤的血管生成,可能是乳宁Ⅱ号的作用机理之一;乳宁Ⅱ号与化疗药CTX有协同作用.
简介:TheallelicdistributionofEcoRIandBamHIfragmentsofrasfamilygenesbetweenthehumanprimarygastriccancertissuesandthecorrespondingadjacentnormaltissuesdidnotshowanydifferences.ThreegenotypesofBamHIrestrictionfragmentslengthpolymorphismofc-H-raswererevealed.NosignificantdifferencesintheRFLPswereobservedbetweennormalindividualsandgastriccancerpatients.Fourprotooncogenes,c-H-ras,N-ras,c-mycandc-fos,werefoundtobetranscriptionallyactiveinthegastriccancertissuesinsomecasesexamined.Thecomparisonoftheexpressionoftheseoncogenesbetweenthemalignanttissuesandthecorrespondingnormaltissuesshoweddifferentialpatterns.Theexpressionofc-H-rasatcellularlevelwasdetectedwithinsituhybridization.Theenhancedexpressionofc-H-rasinthegastriccancercellswasdemonstrated,butthedegreeoftheexpessionamongthecancercellswasshowntobeheterogeneous.Inaddition,theenhancedexpressionofc-H-raswasseeninthei
简介:SYNTHESISANDFINESTRUCTURE-PROPERTYRELATIONSHIPSOFION-CONTAININGBIOMEDICALPOLYETHERURETHANESSYNTHESISANDFINESTRUCTURE-PROPERTY...
简介:目的探索不同f2/f1比值对DPOAEs幅值的影响,寻找最佳的测试参数,以得到最大的DPOAEs测值.方法对12例(24耳)正常青年人进行不同f2/f1比值条件下的DPOAEs幅值测试.结果当f1/f1=1.220时,DPOAEs幅值最大(P<0.05或P<0.01).当f2/f1=1.232时,除了f2=2002Hz处以外,其DPOAEs幅值与f2/f1=1.220时无显著性差异(P>0.05).其他f2/f1值的DPOAEs幅值均较低,多数测值与f2/f1=1.220时相比均有显著性差异(P<0.05或P<0.01).结论f2/f1=1.220~1.232时,DPOAEs测值最大,此范围为最佳测试参数值.
简介:SincetheinventionofRubylaserbyMaimanin1960s,manykindsoflasersareusedwidelyindentistry.Ithasbeenprovedthatlaserirradiationcanproduceacidetchinglikesurface,thusstrengthenthebondofmaterialtoenamel.Buttheheatgeneratedduringirradiationproducesdamageondentalpulp,whichlimitsthelaserapplicationsondentalhardsurfaces.
简介:Biomedicalsegmentedpolyetherurethane(SPEU)elastomersarecompositepoly-merswithmicrophaseseparationstructure.VariousattemptsofintroducingionicgroupsintoSPEUhavebeencarriedoutfortheimprovementoftheirbloodcompati-bilities.Weherereportthemechanicalandanticoagulantproperties.Twoseriesofsulfooctylpendantgroupscontainingsegmentedpolyetherurethaneswithwelldefinedfinestructurehavebeensynthesizedinourlab-oratory.ThesulfooctylgroupswereexactlylocatedatthehardsegmentswhentheSPEUswerepreparedfromthereactionofpolytetramethyleneglycol(PTMG)1000-4,4’diphenylmethanediisocyanate(MDI)oligomerswithN-sulfoalkyldiethanolamine