简介：AbstractBackground:The prevalence of skin diseases and diabetes mellitus (DM) are prominent around the world. The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM (T2DM) is limited, leading to limited recognition of the correlations between skin diseases and T2DM.Methods:We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st, 2016. The subjects were categorized into three groups: Normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and T2DM. The prevalence and clinical characteristics of skin diseases were recorded and investigated.Results:In this cross-sectional study, 383 individuals with ages ranging from 53 to 89-year-old were recruited. The overall prevalence of skin diseases was 93.5%, and 75.7% of individuals had two or more kinds of skin diseases. Additionally, there were 47 kinds of comorbid skin diseases in patients with T2DM, of which eight kinds of skin diseases had a prevalence >10%. The prevalence of skin diseases in NGT, IGT, and T2DM groups were 93.3%, 91.5%, and 96.6%, respectively; stratified analysis by categories showed a statistically significant difference in "disturbances of pigmentation" and "neurological and psychogenic dermatoses" . The duration of T2DM also significantly associated with the prevalence of "disturbances of pigmentation" and "neurological and psychogenic dermatoses" . Subsequently, the prevalence of "disturbances of pigmentation" was higher in males than females in NGT (P < 0.01) and T2DM (P < 0.01) groups. In addition, the difference in the prevalence of "disturbances of pigmentation" was also significant in NGT and T2DM groups (P < 0.01).Conclusions:There was a high prevalence of skin diseases in the Da Qing Diabetes Study. To address the skin diseases in the Da Qing Diabetes Study, increased awareness and intervention measures should be implemented.

简介：Objective:Toobserveclinicaleffectofcombinedmixtureoftraditionalchinesesandwesternmedicine"PIANTANNING"intreatmentofischemiccerebrovasculardiseasesandchangeofbrainatlas.Methods:In6660patientswithischemiccerebrovasculardisease,thecurativeeffectof"PIANTANNING"andbrainatlaswereobservedandother30caseswerecomparedwithtreatmentofDextran.Results:Aftertreatment,patient'sclinicalsymptomsandrecovereddegreeofmyodynamiaandbrainatlasimprovedsignificantly.Totaleffectiveratewas96.7%.Butthecontralgroupwas80.0%.Therewasasignificantdifferencebetweenthem(p＜0.05).Conclusion:The"PIANTANNING"producedagoodclinicalcurativeeffectintreatmentofischemiccerebrovasculardiseasesandthesideeffectwasonlyafew.Soitcanbeappliedverywellinpatientswithischemiccerebrovasculardisease.Theappliedvalueofbrainatlaswasverygood.

简介：ＡＳＴＵＤＹＯＮＴＨＥＰＡＲＡＷＡＬＫＥＲＣＯＮＴＲＯＬＬＥＤＢＹＥＭＧＡＳＴＵＤＹＯＮＴＨＥＰＡＲＡＷＡＬＫＥＲＣＯＮＴＲＯＬＬＥＤＢＹＥＭＧＷａｎｇＲｅｎｃｈｅｎｇ；ＺｈａｎｇＰｅｉｙｕ；ＺｈａｎｇＪｉｃｈｕａｎ；ＪｉｎＤｅｗｅｎ（Ｄｅｐｔ．ｏｆ...

简介：Chlamydia,ahumanpathogenthatmediateschronic,persistentandrepeatedinfectionprogress,iscapableofinflictingpermanentscarformation.Atypicalreticularbodyisfoundinpersistentinfections.ChlamydialHsp60,interferon(IFN)-gammaandothercytokinesfunctioninthecourseofrepeatedinfection.Immunopathologicalfactorsmediatechronicinfection.

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简介：ＩＤｅｐａｒｔｍｅｎｔｏｆＴｈｏｒａｃｉｃ＆ＣａｒｄｉｏｖａｓｃｕｌａｒＳｕｒｇｅｒｙ，ＦｉｒｓｔＵｎｉｖｅｒｓｉｔｙＨｏｓｐｉｔａｌ，ＷｅｓｔＣｈｉｎａＵｎｉｖｅｒｓｉｔｙｏｆＭｅｄｉｃａｌＳｃｉｅｎｃｅｓ，Ｃｈｅｎｇｄｕ，Ｓｉｃｈｕａｎ６１００４...

简介：ＳＴＵＤＹＯＮＳＯＬＵＢＩＬＩＴＹＯＦＡＰＡＴＩＴＥＣＥＲＡＭＩＥＳＩＮＶＩＴＲＯＳＴＵＤＹＯＮＳＯＬＵＢＩＬＩＴＹＯＦＡＰＡＴＩＴＥＣＥＲＡＭＩＥＳＩＮＶＩＴＲＯＬ．ＮｉｎｇＭ．Ｘｕｅ（ＳｈａｎｇｈａｉＳｅｃｏｎｄＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ...

简介：本项研究从仿红细胞出发，将增加双分子脂膜亲水性的ＰＥＧＰＥ（聚乙二醇与磷脂酰乙醇胺的衍生物）及增加双分子脂膜硬度的ＳＭ（神经鞘磷脂）掺入脂质体，比较其在体外稳定性、体内分布及清除半衰期。结果证明该类脂质体稳定性提高，体内被肝、脾清除减少，血循环中半衰期显著延长。本研究为脂质体载药至非网状内皮系统的靶向给药打下基础。

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简介：ＥＬＥＭＥＮＴＡＬＳＴＵＤＹＯＦＧＥＮＥＴＨＥＲＡＰＹＷＩＴＨＴＨＲＯＭＢＯＰＯＩＥＴＩＮＬｕＣｈｅｎｇｒｏｎｇ陆承荣ＺｈａｏＪｉａｎｚｅｎｇ赵建增ＷａｎｇＸｉａｏｐｉｎｇ王小平Ｌｉｕｌｉ刘丽ＲｅｓｅａｒｃｈＣｅｎｔｅｒｏｆＭｏｌｅｃｕｌａｒＢｉｏｌ...

简介：Thetechniqueofcomputersimulationsisaveryefficientmethodininvestigatingmechanismsofmanydiseases.Thispaperreviewshowthesimulationsofthehumanheartstartedasasimplemathematicalmodelsinthepastanddevelopedtothepointwheregeneticinformationisneededtodosuitableworklikefindingoutnewmedicamentsagainstheartdiseases.AlsotheInfluenceofthedevelopmentofcomputerperformanceinthefutureaswellasthedatapresentationisdescribed.

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简介：AbstractObjective:To elucidate the epidermal melanocyte distribution according to sex, age, and body part with the goal of providing benchmark data for the diagnosis and therapeutic effect evaluation of pigmentary skin diseases.Methods:Epidermal melanocytes and keratinocytes were assessed using direct immunofluorescence staining, and the melanocyte density and epidermal thickness were calculated. The obtained data were statistically analyzed using SPSS Version 20.0 software. An independent-samples t test was used to compare the data between two groups, while data among three or more groups were compared by one-way analysis of variance. Data correlations were evaluated using Pearson correlation analysis.Results:Melanocytes were uniformly distributed among the keratinocytes in the basal layer, and the average ratio of melanocytes to keratinocytes was 1:7. Among them, the ratio in males was 1:6.5 and that in females was 1:7.4, with no significant difference (P= 0.127). The melanocyte density gradually declined as age increased; the ratio was 1:5.8 before 50 years of age without an obvious downtrend. The average melanocyte density was 1:7.9 within 51 to 65 years of age and 1:8.5 at >65 years of age, and the difference was statistically significant (P < 0.01). Obvious differences were found in the melanocyte density among different body parts; in descending order, these densities were as follows: face (1:4.0) >neck (1:5.1) >hip (1:5.7) >upper limb (1:7.4) >lower limb (1:8.3) >lower back (1:9.2) >thorax and abdomen (1:9.9). The melanocyte density was not related to the epidermal thickness.Conclusion:The melanocyte density showed a declining trend with age and significantly changed after 50 years of age. The melanocyte density was associated with body part; specifically, the density in the face, neck, and hip was higher than that in the limbs and torso. However, the melanocyte density was not associated with sex or epidermal thickness.

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简介：Heartfailure(HF)isacomplexclinicalsyndromethatresultsfromanystructuralorfunctionalimpairmentofventricularfillingorejectionofblood.HFisoneofthemostimportantandsevereendstagesofmanycardiovasculardiseases.EpidemiologicalstudiesofHFhavefocusedmainlyontheprevalence,incidence,mortality,fatality,anddistributionandtemporaltrendsoftheseindicatorsamongdifferentpopulations.ThisreviewhighlightsimportantepidemiologicalstudiesofHFinChina.

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简介：ＡＮＥＷＭＥＴＨＯＤＦＯＲＳＴＵＤＹＯＦＥＲＹＴＨＲＯＣＹＴＥＳＥＤＩＭＥＮＴＡＴＩＯＮＡＮＥＷＭＥＴＨＯＤＦＯＲＳＴＵＤＹＯＦＥＲＹＴＨＲＯＣＹＴＥＳＥＤＩＭＥＮＴＡＴＩＯＮＺｈａｏＺｈｉｙｕｎ；ＦａｎＪｉａｊｕｎ；ＹａｎｇＣｈｕｎｚｈｉ；ＷｅｎＪ...

简介：AbstractBackground:High sodium intake is an important risk factor for hypertension and cardiovascular disease. However, the association between gut microbiota composition and metabolomic profiles with dietary sodium intake and blood pressure (BP) is not well-understood. The metabolome, microbiome, and dietary salt intervention (MetaSalt) study aimed to investigate microbial and metabolomic profiles related to dietary sodium intake and BP regulation.Methods:This family-based intervention study was conducted in four communities across three provinces in rural northern China in 2019. Probands with untreated prehypertension or stage-1 hypertension were identified through community-based BP screening, and family members including siblings, offspring, spouses, and parents were subsequently included. All participants participated in a 3-day baseline examination with usual diet consumption, followed by a 10-day low-salt diet (3 g/d of salt or 51.3 mmol/d of sodium) and a 10-day high-salt diet (18 g/d of salt or 307.8 mmol/d of sodium). Differences in mean BP levels were compared according to the intervention phases using a paired Student's t-test.Results:A total of 528 participants were included in this study, with a mean age of 48.1 years, 36.7% of whom were male, 76.8% had a middle school (69.7%) or higher (7.1%) diploma, 23.4% had a history of smoking, and 24.4% were current drinkers. The mean arterial pressure at baseline was 97.2 ± 10.5 mm Hg for all participants, and significantly decreased during the low-salt intervention (93.8 ± 9.3, P < 0.0001) and subsequently increased during the high-salt intervention (96.4 ± 10.0, P < 0.0001).Conclusions:Our dietary salt intervention study has successfully recruited participants and will facilitate to evaluate the effects of gut microbiota and metabolites on BP regulation in response to sodium burden, which will provide important evidence for investigating the underlying mechanisms in the development of hypertension and subsequent cardiovascular diseases.Trial registration:The study was registered in the Chinese Clinical Trial Registry database (ChiCTR1900025171).