简介：Inthisstudyalumbarspinalfusionanimalmodelisestablishedtoassesstheeffectofspinalfusioncage,andexploretheminimumarearatiooftitaniumcagesectiontovertebralsectionthatensuresbonehealingandbiomechanicalproperty.Lumbarcorpectomywasconductedbyposterolateralapproachwithtitaniumcageimplantationcombinedwithplatefixation.Titaniumcageswiththesamelengthbutdifferentdiameterswereused.Afterimplantationoftitaniumcages,theprogressofbonehealingwasobservedandthebonebiomechanicalpropertiesweremeasured,includingdeformationanddisplacementinaxialcompression,flexion,extension,andlateralbendingmotion.Thefactorsaffectingtheinvivogrowthofspinesupportingbodywereanalyzed.Theresultsshowthatthearearatiooftitaniumcagesectiontovertebralsectionshouldreach1/2toensurethebonehealing,sufficientboneintensityandbiomechanicalproperties.Somebonehealingindicators,suchasBMP,suggestthatthereisarelationshipbetweenthepeaktimeandthepeakvalueofboneformationandmetabolismmarkersandthebonehealingstrength.