简介：AbstractObjective:The aim of this work was to explore the feasibility of in vivo and non-invasive monitoring of deuterium/hydrogen (2H/1H) exchange at the metabolic level upon exposure to heavy water (2H2O).Methods:The healthy female mice were randomly assigned to two groups after day 0 when both mice received standard drinking water. The treated mouse was fed with 2H2O (80%, v/v) and the control mouse fed with standard drinking water (H2O) over next 13 days. Real-time mass spectrometric analysis of volatile metabolism emitted through breathing and the skin was performed on days 1, 2, 3, 10, 12, and 13. Animal experiment was approved by the Laboratory Animal Ethics Committee of Jinan University (approval No. 20161117163322) on October 29, 2021.Results:We observed a replacement of 1H by 2H in 52 mass spectral features (60 2H/1H isotopologue pairs) for the mouse fed with 2H2O, but not for the control mouse. These included pyruvic acid and lactic acid, lysine and methyl-lysine as well as short-chain fatty acids comprising acetic acid, propionic acid, butyric acid and valeric acid.Conclusion:Secondary electrospray ionization-high resolution mass spectrometry allows monitoring in vivo2H-incorporation of metabolites in a non-invasive and real-time setup and opens new opportunities to use 2H tracing to extend current metabolic studies, especially those with a focus on anaerobic glycolysis, lysine methylation and gut microbiome via monitoring of short-chain fatty acids.
简介：无
简介：TheeffectofyttriaonthesolidreactionmechanismofaCaHPO4·2H2O+CaCO3systematdifferenttemperatureswasexperimentallystud-ied.Thesampleswithandwithoutyttriaweresubjectedtothermogravimetric/differentialscanningcalorimetrymeasurement.ThesampleswereheattreatedatthetemperaturescorrespondingtothepeaksontheDSCspectra,andtheresultedphasecompositionswereidentifiedbyX-raydiffraction.Thetransformationmechanismwasdeducedbycomparingthephasesobtainedatdifferenttemperatures.Theresultsshowthatthetransformationsatbelow1073Karenotaffectedbyyttria,butallthoseatabove1073Karecompletelyaltered.Theformationtem-peratureofhydroxyapatitedecreasesby134K,andthedecompositiontemperatureincreasesby38K.ThepolymorphoustransformationofCa3(PO4)2fromβphasetoαphaseincreasesby47K.Thethermodynamicpropertiesofthetransformationsatabove1073Karealsomodi-fiedbytheadditionofyttria;thatis,theendothermalpeaksaresubstitutedbyexothermalpeaks.
简介：Sodiumparanitrophenolatedihydrate(NPNa·2H2O)isanexcellentsemiorganicnonlinearoptical(NLO)material,crystallizesbothinwaterandmethanolwithhighdegreeoftransparency.Goodopticalqualitysinglecrystalsofdimensionupto18mmx6mmx3mmareobtainedbyisothermalsolventevaporationtechnique.Thesolubilityofthecrystalindifferentsolventswasmeasuredgravimetrically.ThesinglecrystalsofNPNa·2H2Oshowvariationinphysicalpropertiesandgrowthrateindifferentsolvents.Methanolorethanolsolutionyieldscrystalsofbipyramidalshapewithclearmorphology.However,methanolgrowncrystalisexhibitingimprovedhardnessparametersandpossessesexcellentthermalstabilityascomparedtowatergrowncrystals.TheeffectsofsolventonhardnessparameteralongwiththermalandopticalpropertiesofNPNa·2H2Owasrevealedinthispaper.
简介：Thesolidaddofthefirstprotonatedzincoborophosphate,(H3O)Zn(H2O)2BP2O8·H2O(1),wassoventothermallysyn-thesizedbythereactionofZn(NO3)2·6H2OandH3BO3withH3PO4inamixedsolvent,andstructurallycharacterizedbysingle-ystalX-raydiffractionanalysis.ItcrystallizesinthehexagonalP6122,a=0.9604(4)nm,c=1.5297(6)nm,V=1.2218(8)nm^3,Dc=2.921g/cm^3,Z=6,F(000)=1080,μ=3.495mm^-1.Thestmchwefeaturesthatthetetrahedra-te-trahedrahdlcesinterconnectedbyoctahedraandstronghydro-gembondinteractionsformathree-dimensionalframework.Theprotonatedwatermoleculesarelocatedatuniquepositions.othercharacterizationsbyIRandthermalanalysisarealsode-scribed.
简介：石膏的种类很多,但用于制作立体模型的石膏主要是α—半水石膏与β—半水石膏。β—半水石膏以材料低廉、来源广泛、技术成熟而被广泛运用,也早已为刑事技术部门在侦破案件中采用。但对于α—半水石膏,很多从事现场勘查的同志却不大熟悉。一、α—半水石膏的特点及与β—半水石膏的区别。常用的β—半水石膏是普通模型石膏的主要部分,而α—半水石膏是高强模型石膏的主要成分。α型与β型半水石膏虽然在微观结构上相似,但其宏观特性却相差很大。概括起来,它们的差别主要有以下几点:1、在结晶形态上的差别。用扫描电镜观察表明,α型半水石膏是致密的、完整的、粗
简介：AsimplespectrophotometricassayofH2O2andglucoseusingAgnanoparticleshasbeencarriedout.RelyingonthesynergisticeffectofH2O2reductionandultraviolet(UV)irradiation,Agnanoparticleswithenhancedabsorptionsignalsweresynthesized.H2O2servedasareducingagentintheAgnanoparticlesformationinwhichAg+wasreducedtoAg0byO2àgeneratedviathedecompositionofH2O2inalkalinemedia.Ontheotherhand,photoreductionofAg+toAg0underUVirradiationsalsocontributedtothenanoparticlesformation.ThesynthesizednanoparticleswerecharacterizedbyTEM,XPS,andXRD.TheproposedmethodcoulddetermineH2O2withconcentrationsrangingfrom5.010à7to6.010à5mol/L.Thedetectionlimitwasestimatedtobe2.010à7mol/L.SincetheconversionofglucosetogluconicacidcatalyzedbyglucoseoxidasewascompaniedwiththeformationofH2O2,thesensingprotocolhasbeensuccessfullyutilizedforthedeterminationofglucoseinhumanbloodsamples.Theresultswereingoodagreementwiththosedeterminedbyalocalhospital.Thiscolorimetricsensorthusholdsgreatpromisesinclinicalapplications.
简介：通过三步合成(E)-二(对3-硝基苯甲酸)乙烯(C16H10N2O8)配体,并由此通过溶剂热法合成金属有机框架材料Zn2(EBNB)2(BPY)2·2H2O;采用x射线单晶衍射分析、红外光谱(IR)和热重分析(TG)等对所得结构进行表征,并测试其荧光性能;以洛贝林为模型药物,研究了Zn2(EBNB)2(BPY)2·2H2O对该药物的载药及体外释药性能。研究结果说明,Zn2(EBNB)2(BPY)2·2H2O对洛贝林的最高载入量达0.355g/g,载药体系的体外释药为明显的两相模式。体外细胞毒性实验结果表明,Zn2(EBNB)2(BPY)2·2H2O具有良好的生物相容性。
简介：合成了一种未见报道的标题化合物（（C5N2H6）3（C5N2H7）3[（PO4）Mo12O36]·2H2O,Mr=2403.00）并得到单晶,晶体衍射实验发现其属于单斜晶系,P2（1）/n空间群,晶体学参数：a=13.316（3）,b=22.414（5）,c=20.063（4）,α=90.00（4）°,β=100.743（3）°,γ=90.00°,V=5883（2）3,Z=4,Dc=2.713Mg/m3,μ（MoKα）=2.608mm-1,F000=4604,最终R=0.0596,wR=0.1345,GoF=1.042.配体由由簇阴离子[（PO4）Mo12O36]3-之间通过端基氧与2-氨基吡啶形成氢键而相互连接,中间填充了一些水分子及2-氨基吡啶.
简介：Twooxo-vanadium(IV)complexes,[VO(C2O4)(2,2′-bipy)(H2O)]·C2H5OH(1)andVO(C2O4)(phen)(H2O)(2),where2,2′-bipy=2,2′-bipyridyl,phen=1,10-phenanthroline,weresynthesizedaspotentialfunctionalmodelsofvanadiumhaloperoxidases(VHPOs)inmixedsolventofethanolandwateratroomtemperature.Thecomplexeswerecharacterizedbyelementalanalysis,infrared(IR),UV-VisandX-raycrystallography.Structuralanalysesshowedthatvanadiumatomwascoordinatedbyaterminaloxygen,oneoxygenatomfromcoordinatedwater,twooxygenatomsfromthecarboxylategroupofoxalicacid,andtwonitrogenatoms(N1andN2)from2,2′-bipy/phen.Centralvanadiumatomsincomplexes1and2werebothinadistorted-octahedralenvironment,andsomeintermolecularhydrogenbondinglinkageswerealsoobservedineachcomplex.BrominationreactionactivityofthetwocomplexeswasevaluatedwithphenolredasorganicsubstrateinthepresenceofH2O2,Br-andphosphatebuffer,indicatingthattheycanbeconsideredasapotentialfunctionalmodelofVHPO.Inaddition,thermalanalysiswasalsoperformedanddiscussedindetail.
简介：本文报道了Ｃ６Ｈ１２Ｏ６（ＮＨ４）２ＳＯ４Ｃ２Ｈ５ＯＨＨ２Ｏ（Ｃ２Ｈ５ＯＨ／Ｈ２Ｏ＝０．９０）体系在３５℃时体系溶解度和饱和溶液的折光指数，并绘出了体系相应的溶度图和饱和溶液的折光指数曲线图。结果表明：所研究的体系为四元体系Ｃ６Ｈ１２Ｏ６（ＮＨ４）２ＳＯ４Ｃ２Ｈ５ＯＨＨ２Ｏ中的一部分。当溶液中肌醇饱和时，溶度曲线落在约５０％的等醇水比面上。当（ＮＨ４）２ＳＯ４在溶液中达到饱和时，出现共饱点。其组成为（ＮＨ４）２ＳＯ４：２１０％，Ｃ６Ｈ１２Ｏ６：２．０８％，Ｃ２Ｈ５ＯＨ：４４７５％。同时出现分层，在富醇相随着乙醇浓度的增加，出现肌醇与硫酸铵共饱线。在富水相硫酸铵饱和溶度曲线落在约５％乙醇的等醇水比面上，折光指数曲线由三支组成，其中两条分别与Ｃ６Ｈ１２Ｏ６·Ｈ２Ｏ和（ＮＨ４）２ＳＯ４相对应，另外一条线与（ＮＨ４）２ＳＯ４和Ｃ６Ｈ１２Ｏ６·Ｈ２Ｏ的共饱线相对应
简介：Thecopper(Ⅱ）complex[Cu3(nta)2(azpy)2(H2O2)]·6H2O(nta=nitrilotriacetate,azpy=4,4′-azobispyridine)hasbeensynthesizedandcharacterized.TheX-rayanalysisrevealsthattherearetwokindsofcopper(Ⅱ）coordinationenvironments.Cu(1)hasadistortedsquareplanesymmetryandCu(2)hasadistortedoctahedralsymmetry.Cu(1)islinkedtoCu(2)throughntaandboundtoCu(1C)byazpy,andCu(2)islinkedtoCu(2A)throughazpy,whichextendstotwo-dimensionalnetworkwithlargerhombus1.2nm×1.7nm.
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![Crystal Structure and Bioactivity of Complex [Gd（C10<b style='color:red'>H</b>9N<b style='color:red'>2</b><b style='color:red'>O</b>4）（C10<b style='color:red'>H</b>8N<b style='color:red'>2</b><b style='color:red'>O</b>4）（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>）3]<b style='color:red'>2</b>·phen·4<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>](/image/thesis9 "Crystal Structure and Bioactivity of Complex [Gd（C10<b style='color:red'>H</b>9N<b style='color:red'>2</b><b style='color:red'>O</b>4）（C10<b style='color:red'>H</b>8N<b style='color:red'>2</b><b style='color:red'>O</b>4）（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>）3]<b style='color:red'>2</b>·phen·4<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>")
![新型杂多酸（C5N<b style='color:red'>2</b><b style='color:red'>H</b>6）3（C5N<b style='color:red'>2</b><b style='color:red'>H</b>7）3[（PO4）Mo12<b style='color:red'>O</b>36]·<b style='color:red'>2</b><b style='color:red'>H2O</b>的水热合成与晶体结构](/image/thesis11 "新型杂多酸（C5N<b style='color:red'>2</b><b style='color:red'>H</b>6）3（C5N<b style='color:red'>2</b><b style='color:red'>H</b>7）3[（PO4）Mo12<b style='color:red'>O</b>36]·<b style='color:red'>2</b><b style='color:red'>H2O</b>的水热合成与晶体结构")
![Syntheses, Crystal Structures and Characterization of Two Zeotype Crystals of K4[Cr30（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>） 3（OOCH） 6] <b style='color:red'>2</b>[ P<b style='color:red'>2</b>W18<b style='color:red'>O</b>62]· 9.5<b style='color:red'>H</b><b style='color:red'>2</b> <b style='color:red'>O</b> and K4[ Cr3<b style='color:red'>O</b>（ <b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>）3（ OOCH）6 ]<b style='color:red'>2</b>[ <b style='color:red'>H</b>3 P<b style='color:red'>2</b> W17Co（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>） <b style='color:red'>O</b>61]· 20<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>](/image/thesis12 "Syntheses, Crystal Structures and Characterization of Two Zeotype Crystals of K4[Cr30（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>） 3（OOCH） 6] <b style='color:red'>2</b>[ P<b style='color:red'>2</b>W18<b style='color:red'>O</b>62]· 9.5<b style='color:red'>H</b><b style='color:red'>2</b> <b style='color:red'>O</b> and K4[ Cr3<b style='color:red'>O</b>（ <b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>）3（ OOCH）6 ]<b style='color:red'>2</b>[ <b style='color:red'>H</b>3 P<b style='color:red'>2</b> W17Co（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>） <b style='color:red'>O</b>61]· 20<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>")
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![Vanadium Haloperoxidases Model Compounds： Synthesis, Structural Characterization and Mimic Catalytic Bromination Activity of [VO（C_<b style='color:red'>2</b><b style='color:red'>O</b>_4）（<b style='color:red'>2</b>,<b style='color:red'>2</b>′-bipy）（<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>）]·C_<b style='color:red'>2</b><b style='color:red'>H</b>_5OH and VO（C_<b style='color:red'>2</b><b style='color:red'>O</b>_4）（phen）（<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>）](/image/thesis16 "Vanadium Haloperoxidases Model Compounds： Synthesis, Structural Characterization and Mimic Catalytic Bromination Activity of [VO（C_<b style='color:red'>2</b><b style='color:red'>O</b>_4）（<b style='color:red'>2</b>,<b style='color:red'>2</b>′-bipy）（<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>）]·C_<b style='color:red'>2</b><b style='color:red'>H</b>_5OH and VO（C_<b style='color:red'>2</b><b style='color:red'>O</b>_4）（phen）（<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>）")
![Synthesis,Structure and Characterization of Two—dimensional Network Copper Complex [Cu3（nta）<b style='color:red'>2</b>（azpy）<b style='color:red'>2</b>（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>）<b style='color:red'>2</b>]·6<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>](/image/thesis18 "Synthesis,Structure and Characterization of Two—dimensional Network Copper Complex [Cu3（nta）<b style='color:red'>2</b>（azpy）<b style='color:red'>2</b>（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>）<b style='color:red'>2</b>]·6<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>")
