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简介:AbstractMucormycosis is a lethal human disease caused by fungi of the order Mucorales. Mucormycosis is caused by fungi mainly belonging to the genera Mucor, Rhizopus, and Lichtheimia, all of which belong to the order Mucorales. The number of individuals with mucormycosis-causing disorders has increased in recent years, hence, leading to the spread of mucormycosis. Throughout the coronavirus disease 2019 (COVID-19) pandemic, numerous cases of mucormycosis in COVID-19-infected patients have been reported worldwide, and the illness is now recognized as COVID-19-associated mucormycosis, with most of the cases being reported from India. Immunocompromised patients such as those with bone marrow sickness and uncontrolled diabetes are at a greater risk of developing mucormycosis. Genes, pathways, and other mechanisms have been studied in Mucorales, demonstrating a direct link between virulence and prospective therapeutic and diagnostic targets. This review discusses several proteins such as high-affinity iron permease (FTR1), calcineurin, spore coat protein (CotH), and ADP-ribosylation factors involved in the pathogenesis of mucormycosis that might prove to be viable target(s) for the development of novel diagnostic and therapeutic methods.
简介:摘要:为了满足经济发展和社会的实际需要,重载铁路的建设数量逐渐增多,重载轨道的维修养护工作对于维护铁路的安全、稳定运行至关重要。铁路工作人员应结合施工现场的实际状况,合理制订养护方案,保证列车的稳定运行。就重载铁路线路维修养护工作进行了详细讨论。
简介:摘要:制动缸作为制动系统输出力的产生装置,是制动力的直接来源,对于列车制动系统有着至关重要的影响。我国重载铁路货车采用的120-1型制动机是两压力直接作用式制动机,按照传统观点,制动缸压力仅受副风缸-制动缸容积匹配关系影响。本文分析了列车环境下制动缸压力分布的实际情况,并对列车中制动缸压力的影响因素进行分析,找出了列车管减压特性差异、制动阀动作差异、副风缸充风差异、局减量差异、制动缸活塞行程差异等一系列影响制动缸压力的因素。