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简介：AbstractMucormycosis is a lethal human disease caused by fungi of the order Mucorales. Mucormycosis is caused by fungi mainly belonging to the genera Mucor, Rhizopus, and Lichtheimia, all of which belong to the order Mucorales. The number of individuals with mucormycosis-causing disorders has increased in recent years, hence, leading to the spread of mucormycosis. Throughout the coronavirus disease 2019 (COVID-19) pandemic, numerous cases of mucormycosis in COVID-19-infected patients have been reported worldwide, and the illness is now recognized as COVID-19-associated mucormycosis, with most of the cases being reported from India. Immunocompromised patients such as those with bone marrow sickness and uncontrolled diabetes are at a greater risk of developing mucormycosis. Genes, pathways, and other mechanisms have been studied in Mucorales, demonstrating a direct link between virulence and prospective therapeutic and diagnostic targets. This review discusses several proteins such as high-affinity iron permease (FTR1), calcineurin, spore coat protein (CotH), and ADP-ribosylation factors involved in the pathogenesis of mucormycosis that might prove to be viable target(s) for the development of novel diagnostic and therapeutic methods.

简介：AbstractIn order to effectively implement the Tianjin Biosecurity Guidelines for Codes of Conduct for Scientists, biosecurity awareness-raising and education are essential because if these are not in place scientists will not understand the need for biosecurity codes of conduct. In an effort to assist in the implementation of the guidelines, a small-scale survey was carried out in early 2022 of biosecurity awareness-raising and education projects that have been developed over the last two decades to discover what resources and experience have been accumulated. It is argued that the survey demonstrates that much of what is needed to implement the guidelines effectively has been developed, but that there are specific deficiencies that need to be remedied quickly. In particular, an updated teaching resource covering the core issues related to the Biological and Toxin Weapons Convention (BTWC) and the problem of dual use in scientific research needs to be made widely available and translated into at least the six official United Nations (UN) languages. Additionally, more specialists from the Humanities with expertise in ethics need to become involved in biosecurity awareness-raising and education activities. While advantage should be taken now of the available national, regional and international networks of people involved in related activities, it is suggested that in the longer term cooperation in biosecurity awareness-raising and education will benefit from the development of an equivalent organisation to the International Nuclear Security Education Network (INSEN) organised through the International Atomic Energy Agency (IAEA).

简介：AbstractBackground:Zoonoses are public health threats that cause severe damage worldwide. Zoonoses constitute a key indicator of One Health (OH) and the OH approach is being applied for zoonosis control programmes of zoonotic diseases. In a very recent study, we developed an evaluation system for OH performance through the global OH index (GOHI). This study applied the GOHI to evaluate OH performance for zoonoses in sub-Saharan Africa.Methods:The framework for the OH index on zoonoses (OHIZ) was constructed including five indicators, 15 subindicators and 28 datasets. Publicly available data were referenced to generate the OHIZ database which included both qualitative and quantitative indicators for all sub-Sahara African countries (n = 48). The GOHI algorithm was used to estimate scores for OHIZ. Indicator weights were calculated by adopting the fuzzy analytical hierarchy process.Results:Overall, five indicators associated with weights were generated as follows: source of infection (23.70%), route of transmission (25.31%), targeted population (19.09%), capacity building (16.77%), and outcomes/case studies (15.13%). Following the indicators, a total of 37 sub-Sahara African countries aligned with OHIZ validation, while 11 territories were excluded for unfit or missing data. The OHIZ average score of sub-Saharan Africa was estimated at 53.67/100. The highest score was 71.99 from South Africa, while the lowest score was 40.51 from Benin. It is also worth mentioning that Sub-Sahara African countries had high performance in many subindicators associated with zoonoses, e.g., surveillance and response, vector and reservoir interventions, and natural protected areas, which suggests that this region had a certain capacity in control and prevention or responses to zoonotic events.Conclusions:This study reveals that it is possible to perform OH evaluation for zoonoses in sub-Saharan Africa by OHIZ. Findings from this study provide preliminary research information in advancing knowledge of the evidenced risks to strengthen strategies for effective control of zoonoses and to support the prevention of zoonotic events.

简介：AbstractBackground:Being able to predict with confidence the early onset of type 2 diabetes from a suite of signs and symptoms (features) displayed by potential sufferers is desirable to commence treatment promptly. Late or inconclusive diagnosis can result in more serious health consequences for sufferers and higher costs for health care services in the long run.Methods:A novel integrated methodology is proposed involving correlation, statistical analysis, machine learning, multi-K-fold cross-validation, and confusion matrices to provide a reliable classification of diabetes-positive and -negative individuals from a substantial suite of features. The method also identifies the relative influence of each feature on the diabetes diagnosis and highlights the most important ones. Ten statistical and machine learning methods are utilized to conduct the analysis.Results:A published data set involving 520 individuals (Sylthet Diabetes Hospital, Bangladesh) is modeled revealing that a support vector classifier generates the most accurate early-onset type 2 diabetes status predictions with just 11 misclassifications (2.1% error). Polydipsia and polyuria are among the most influential features, whereas obesity and age are assigned low weights by the prediction models.Conclusion:The proposed methodology can rapidly predict early-onset type 2 diabetes with high confidence while providing valuable insight into the key influential features involved in such predictions.

简介：摘要：本文的实践探索旨在为国有企业基层团组织“组织力”提升工作摸索出一个相对科学的内容体系，比较规范的操作模式以及相对标准的可复制形态，希望对相关单位和工作人员有参考意义。

简介：摘要：加强基层党组织的组织建设，是新时期加强党的领导及其有效提高基层党建工作效率的重要内容。当前，国内外学者对如何增强基层党组织的组织能力、实现途径等进行了深入的探讨，并取得了一系列的成果。但是，目前关于新时期形式下基层党组织组织力提升的研究还存在着针对性及其深度方面的问题。于此本文从基层党组织组织力的基本内涵出发，浅谈其存在的问题以及相应措施，以助力于基层党组织组织力的提升。

简介：摘要：我们党历来就重视党支部建设，始终把党支部建设作为组织建设的基础和关键。强化机关基层党组织组织力是进一步抓好党要管党、从严治党、夯实党委主体责任的关键举措，切实树牢“四个意识”，坚定“四个自信”，坚决捍卫“两个确立”，自觉做到“两个维护”。

简介：摘要：现阶段城市化建设的不断加快，地铁已经成为城市建设中一项非常重要的内容，也是当前城市居民出行的主要方式。由于现阶段地铁行车安全受到越来越多人重视，因此要针对地铁运行中有关行车组织职责和客运组织情况相关内容进行深入探讨。

简介：摘要：现如今，随着我国经济的快速发展，中央越来越重视医院基层党组织建设，医院党组织要不断创新思想，加强党员思想建设。鉴于此，本文立足当前医院党组织建设现状，探讨新常态下推进党建工作的策略。

简介：摘要：近年来，人们的出行越来越依赖地铁，这也导致地铁车站的人流量不断增加，特别是在节假日人流量更是达到高峰。因而地铁运营的线路以及里程的量也随之增多，同时换乘车站的功能也变得越来越复杂，为了在这种现状下保证地铁车站的服务质量，需要对每一条地铁线路进行一体化管理并协同运营。此外，地铁列车数量的增多也使得各地区车站更加注重缩减车辆间隔的问题。本文对客运组织情况以及行车组织职责进行了深入分析，旨在进一步确保地铁列车的稳定运营。

简介：摘要：随着社会的不断发展和进步，城市化进程的加快，园林绿化工程对于我国的城市建设起着越来越重要的作用。在园林绿化施工过程中，反季节施工是最较为常见的施工工艺，在进行反季节施工时，要遵循一定的规则，遵守绿植的生长习性，在合适的时间进行反季节栽植。利用反季节施工技术，能够突破季节对种植绿化的影响，加快施工进度，缩短施工工期，在最短的时间的完成园林景观效果。本文从优化城市形象、改善生活环境以及提升绿化水平几方面着手，阐述了反季节施工技术的重要性，阐述园林绿化工程反季节施工存在的问题提出了几点应对策略，为我国城市园林绿化工程高质量建设创造良好的条件。

简介：摘要目的探讨我国在有组织科研背景下的大型医院科研平台的有组织建设路径及建设目标。方法通过查阅相关文献资料，对国际及国内现有的有组织科研的科研平台建设进行分析，阐述有组织科研背景下的临床医院科研平台建设的重要性与必要性，并结合临床医院有组织科研平台的建设提出建议。结果有组织的科研需要有组织的建设科研平台。有组织的科研平台建设始终要围绕国家重大需求，服务于重大科学计划，在坚持跨学科、多层次协同创新发展的原则下，进行有组织的人才培养和内部高效的有序组织运行。科研平台的建设逻辑应该是从线性思考到立体思维，从静态单向的服务到动态共生的创新生态格局。结论应对"十四五"国家科技战略需求，有组织地进行科研平台的升级、整合、扩容、完善，形成多学科交叉立体的平台架构，保障有组织科研的顺利推进。

简介：摘要：党的基层组织是党的战斗堡垒，是确保党的路线方针政策和决策部署贯彻落实的基础，承载着新时代的责任与担当。提升基层党组织群众组织力是马克思主义政党建设的基本要求，有其独特的理论逻辑、历史逻辑和现实逻辑。进入新时代，提升基层党组织群众组织力的现实场域在经济基础、制度体系、党员数量和新媒体技术等方面具有显著优势，但由于社会环境改变、主观意识偏差、个别基层干部脱离群众等原因也带来了一些现实挑战。通过阐释基层党组织建设中组织力提升的重要意义，分析了企业党建工作现状，对提升企业基层党组织建设中组织力路径进行了探索。

简介：摘要：党的十九大报告指出：“党的基层组织是确保党的路线方针政策和决策部署贯彻落实的基础。要以提升组织力为重点，突出政治功能，把企业、农村、机关、学校、科研院所、街道社区、社会组织等基层党组织建设成为宣传党的主张、贯彻党的决定、领导基层治理、团结动员群众、推动改革发展的坚强战斗堡垒。”当前，如何提升基层党组织的组织力，做好基层党建工作，是每个党务工作者应该思考和探索的课题。

简介：摘要：新时代只有不断提升高校基层党组织的组织力，才能促进高校党建工作发展，以高质量党建引领推动高校高质量发展。本文通过分析制约高校基层党组织组织力提升的相关因素，提出高校基层党组织组织力提升的具体路径，即从提升决策执行力、提升组织创造力、加大服务推动力、激发自我革新力等方面探索提升党组织组织力，从而促进高校党建工作的高质量发展。

简介：摘要：高校是基层党组织建设工作的关键主体，承担了教育职责任务。高校基层党组织需要把提升组织力作为工作主要目标，完善优化基层组织，调整优化活动方式，增强基层党组织影响力和扩大影响范围。因此，需要认识到高校基层党组织组织力提升的必要性，探究提升高校基层党组织组织力的影响因素，采取有效的措施寻求正确的路径，提升高校基层党组织组织力。对于此，本文针对这一方面的内容进行分析和探讨，以供相关人员参考。

简介：摘要：基层党组织作为党的基本细胞，其组织力和政治引导力直接影响着新时期党建工作的顺利开展。在新时代下，基层党组织必须要充分发挥自身的示范、激励和引导作用，切实有效提升基层党组织的组织力，为提升党的凝聚力和创造力奠定重要基础。纵观当前基层党组织的工作现状，在组织力提升方面存在一定的薄弱环节，基于此本文主要对基层党组织组织力缺失的表现加以分析，进而提出组织力提升的优化策略，以供基层党组织学习和借鉴。

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简介：摘要：习近平总书记在党的十九大报告中指出：“要以提升组织力为重点，突出政治功能，把企业、农村、机关、学校、科研院所、街道社区、社会组织等基层党组织建设成为宣传党的主张、贯彻党的决定、领导基层治理、团结动员群众、推动改革发展的坚强战斗堡垒。”这是党中央对党的基层组织建设的新部署、新目标、新定位、新举措，为全面加强基层党组织建设指明了方向。一些基层党组织的组织力仍有软弱涣散现象，不同程度存在弱化、虚化、边缘化问题，支部战斗堡垒作用和党员先锋模范作用得不到充分发挥，如何走出“三化”问题，提升基层党组织的组织力，是当前基层党组织建设需要攻克的重点。