简介:Oligodeoxynucleotides(ODN)containingunmethylatedCpGdinucleotidesincontextsofuniquesequence(CpGmotifs)isactiveasadjuvantininductionofcellularandhumoralimmuneresponsesinyoungmice.Todate,thereareonlylimitedreportsabouteffectofCpGODNonimmuneresponsesagainsthepatitisB(HB)infectioninagedmice.Ourstudiesdemonstratedthereweresignificantincreasesinsecretingoftotalanti-HBIgG,IgG1andIgG2a,aswellasofIL-12andIFN-γ,whenCpGODNswereinjectedtogetherwithhepatitisBantigeninagedmice.Moreover,CpGODNcouldstimulateproliferationofspleenlymphocytesinadose-dependentmanner.Takentogether,theresultsweobtainedindicatethattheaddingofCpGODNintothevaccineantigenmightbeusefulindevelopmentofmoreeffectivevaccinationforinducinganti-HBvirusresponsesintheelderly.
简介:摘要:随着网络技术的不断发展,宽带固定网络(宽固)已成为人们日常生活和工作中不可或缺的一部分。作为宽固网络的重要组成部分,光分配网络(ODN)的性能直接影响着客户的感知体验。本文旨在深入研究ODN链路对宽固客户感知的影响,并提出相应的优化举措。通过实地测试、数据分析和问卷调查等多种方法,本文发现ODN链路的光功率、衰减和时延等关键性能指标与客户感知体验存在显著关联。基于此,本文提出了针对性的优化举措,以期提升宽固客户的感知体验。