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  • 简介:APRIL2015ChinaPledgesEducation,Hospital,JurorSystemReformsOnApr.1,China’scentralauthoritiesrolledoutplanstosupportruralteachers,overhaulpublichospitalsandimprovepublicsupervisionofcourtcases.Theplanswereadoptedatthe11thmeetingofthecentralleadinggroupfordeepeningoverallreformonWednesday,duringwhichPresidentXiJinping,whoisalso

  • 标签: DEEPENING authorities SUPERVISION COURT APRIL issued
  • 简介:BeijinghasbeenoneoftheepicentersattackedmostseverelybytheSARS-CoV(severeacuterespiratorysyndrome-associatedcoronavirus)sincethefirstpatientwasdiagnosedinoneofthecity'shospitals.WenowreportcompletegenomesequencesoftheBJGroup,includingfourisolates(IsolatesBJ01,BJ02,BJ03,andBJ04)oftheSARS-CoV.ItisremarkablethatallmembersoftheBJGroupshareacommonhaplotype,consistingofsevenlocithatdifferentiatethegroupfromotherisolatespublishedtodate.Among42substitutionsuniquelyidentifledfromtheBJgroup,32arenon-synonymouschangesattheaminoacidlevel.Rootedphylogenetictrees,proposedonthebasisofhaplotypesandothersequencevariationsofSARS-CoVisolatesfromCanada,USA,Singapore,andChina,gaverisetodifferentparadigmsbutpositionedtheBJGroup,togetherwiththenewlydiscoveredGD01(GD-Ins29)inthesameclade,followedbytheH-UGroup(fromHongKongtoUSA)andtheH-TGroup(fromHongKongtoToronto),leavingtheSPGroup(Singapore)moredistant.ThisresultappearstosuggestapossibletransmissionpathfromGuangdongtoBeijing/HongKong,thentoothercountriesandregions.

  • 标签: SARS 冠状病毒 全基因序列 北京株
  • 简介:TheR(replicase)proteinistheuniquelydefinednon-structuralprotein(NSP)responsibleforRNAreplication,mutationrateorfidelity,regulationoftranscrip-tionincoronavirusesandmanyotherssRNAviruses.Basedonourcompletegenomesequencesoffourisolates(BJ01-BJ04)ofSARS-CoVfromBeijing,China,weanalyzedthestructureandpredictedfunctionsoftheRproteinincomparisonwith13otherisolatesofSARS-CoVand6othercoronaviruses.TheentireORF(open-readingframe)encodesfortwomajorenzymeactivities,RNA-dependentRNApolymerase(RdRp)andproteinaseactivities.TheRpolyproteinunder-goesacomplexproteolyticprocesstoproduce15function-relatedpeptides.Ahydrophobicdomain(HOD)andahydrophilicdomain(HID)arenewlyidentifiedwithinNSP1.ThesubstitutionrateoftheRproteinisclosetotheaverageoftheSARS-CoVgenome.ThefunctionaldomainsinallNSPsoftheRproteingivedifferentphylogeneticresultsthatsuggesttheirdifferentmutationrateunderselectivepressure.ElevenhighlyconservedregionsinRdRpandtwelvecleavagesitesby3CLP(chymotrypsin-likeprotein)havebeenidentifiedaspotentialdrugtargets.Findingssuggestthatitispossibletoobtaininformationaboutthephy-logenyofSARS-CoV,aswellaspotentialtoolsfordrugdesign,genotypinganddiagnosticsofSARS.

  • 标签: SARS 冠状病毒 R蛋白 结构 功能 基因序列
  • 简介:班级的管理对学生的成长具有十分重要的意义。本文分析了班级管理“113”模式,即用民主激发学生,用制度管理学生,用爱心感染学生,用同心理解学生,用耐心教育学生。

  • 标签: 班级管理 模式 “113”
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  • 简介:目的探讨产后出血的原因、相关因素及防治措施。方法对本院2007年1月至2008年12月住院分娩的113例产后出血患者的临床资料进行回顾性分析,探讨病因、相关因素及防治措施。结果产后出血的原因依次为宫缩乏力、产科因素、胎盘因素、子宫因素、软产道损伤、全身因素和凝血机制障碍。流产、多次妊娠、妊娠并发症增加产后出血率。结论产后出血与多种因素有关,宫缩乏力是最常见的病因。正确估计产后出血量,及时采取抢救措施,能降低产后出血的发生率。

  • 标签: 产后出血 原因 防治
  • 简介:越战期间,在越南南方,浑身沾满泥土又极端缺乏武器的越共游击队,本来不是用当时所有高科技武器武装起来的美军和南越伪军的对手,可赤足的越共游击队在北方老师的点拨下却使用了许多“可恶”的诡计,按现在的话说就是非对称作战,结果将战争引入泥潭,于是双方的位置立即交换。泥泞的稻田和沼泽成了美军和南越伪军的葬身之所,而越共游击队却得益不浅。

  • 标签: 游击队 美军 战争 武器 泥土 越南