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  • 简介:APRIL2015ChinaPledgesEducation,Hospital,JurorSystemReformsOnApr.1,China’scentralauthoritiesrolledoutplanstosupportruralteachers,overhaulpublichospitalsandimprovepublicsupervisionofcourtcases.Theplanswereadoptedatthe11thmeetingofthecentralleadinggroupfordeepeningoverallreformonWednesday,duringwhichPresidentXiJinping,whoisalso

  • 标签: DEEPENING authorities SUPERVISION COURT APRIL issued
  • 简介:BeijinghasbeenoneoftheepicentersattackedmostseverelybytheSARS-CoV(severeacuterespiratorysyndrome-associatedcoronavirus)sincethefirstpatientwasdiagnosedinoneofthecity'shospitals.WenowreportcompletegenomesequencesoftheBJGroup,includingfourisolates(IsolatesBJ01,BJ02,BJ03,andBJ04)oftheSARS-CoV.ItisremarkablethatallmembersoftheBJGroupshareacommonhaplotype,consistingofsevenlocithatdifferentiatethegroupfromotherisolatespublishedtodate.Among42substitutionsuniquelyidentifledfromtheBJgroup,32arenon-synonymouschangesattheaminoacidlevel.Rootedphylogenetictrees,proposedonthebasisofhaplotypesandothersequencevariationsofSARS-CoVisolatesfromCanada,USA,Singapore,andChina,gaverisetodifferentparadigmsbutpositionedtheBJGroup,togetherwiththenewlydiscoveredGD01(GD-Ins29)inthesameclade,followedbytheH-UGroup(fromHongKongtoUSA)andtheH-TGroup(fromHongKongtoToronto),leavingtheSPGroup(Singapore)moredistant.ThisresultappearstosuggestapossibletransmissionpathfromGuangdongtoBeijing/HongKong,thentoothercountriesandregions.

  • 标签: SARS 冠状病毒 全基因序列 北京株
  • 简介:TheR(replicase)proteinistheuniquelydefinednon-structuralprotein(NSP)responsibleforRNAreplication,mutationrateorfidelity,regulationoftranscrip-tionincoronavirusesandmanyotherssRNAviruses.Basedonourcompletegenomesequencesoffourisolates(BJ01-BJ04)ofSARS-CoVfromBeijing,China,weanalyzedthestructureandpredictedfunctionsoftheRproteinincomparisonwith13otherisolatesofSARS-CoVand6othercoronaviruses.TheentireORF(open-readingframe)encodesfortwomajorenzymeactivities,RNA-dependentRNApolymerase(RdRp)andproteinaseactivities.TheRpolyproteinunder-goesacomplexproteolyticprocesstoproduce15function-relatedpeptides.Ahydrophobicdomain(HOD)andahydrophilicdomain(HID)arenewlyidentifiedwithinNSP1.ThesubstitutionrateoftheRproteinisclosetotheaverageoftheSARS-CoVgenome.ThefunctionaldomainsinallNSPsoftheRproteingivedifferentphylogeneticresultsthatsuggesttheirdifferentmutationrateunderselectivepressure.ElevenhighlyconservedregionsinRdRpandtwelvecleavagesitesby3CLP(chymotrypsin-likeprotein)havebeenidentifiedaspotentialdrugtargets.Findingssuggestthatitispossibletoobtaininformationaboutthephy-logenyofSARS-CoV,aswellaspotentialtoolsfordrugdesign,genotypinganddiagnosticsofSARS.

  • 标签: SARS 冠状病毒 R蛋白 结构 功能 基因序列
  • 简介:有一种充满了活力、创新、优雅和精致的生活方式。这种生活方式把美丽与活力、个性与经典完美的结合起来。这种生活方式让你永远领先,让你成为毋庸置疑的领导者。这种生活方式完美的阐释生活的美好,赋予您勇气和独特的非凡想象。这种生活方式让您完全感受到自由,快乐,放荡不羁。选择这种生活方式的人会选择PERSHING,感受生活的激情和无限乐趣。PERSHING的宗旨:精致、高速、优雅、舒适驾驭的特权只留给事业成功的杰出人士。

  • 标签: 感受生活 PERSHING 115 保时捷 项目团队 劳斯莱斯
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  • 简介:摘要对我院自2014年6月~2015年5月收治的130例胸腔积液患者的临床资料进行回顾性分析。

  • 标签: 临床 检查
  • 简介:第一,项目划分,以现行全统定额、行业定额、地方定额为基础,与《建设工程工程量清单计价规范》GB50500-2013(以下简称2013版《清单计价规范》)的章、节顺序相衔接。切实反映新技术、新工艺、新材料、新设备变化情况,调整不合理项目,删除技术淘汰项目,增加建筑节能、环保等项目。

  • 标签: 《建设工程工程量清单计价规范》 定额 装饰工程 房屋建筑 消耗量 解析
  • 简介:近年来,集成电路类电子产品走私活动频繁,对我国电子市场健康发展带来一定的影响,国务院领导对此专门作出批示。为此,根据海关总署2016年打私工作部署,海关总署缉私局将打击电子产品走私列为'国门利剑2016'联合专项行动的重点任务,部署重兵、重拳出击,开展打击整治。

  • 标签: 使命收网 收网行动