简介：<正>Researchinpaediatricexercisemetabolismhasbeenconstrainedbybeingunabletointerrogatemuscleinvivo.Conventionally,researchhasbeenlimitedtotheestimationofmusclemetabolismfromobservationsofbloodandrespiratorygasesduringmaximalorsteadystateexerciseandtheanalysisofafewmusclebiopsiestakenatrestorpost-exercise.Thepurposeofthispaperistoreviewhowtheintroductionof31P-magneticresonancespectroscopyandbreath-by-breathoxygenuptakekineticsstudieshascontributedtocurrentunderstandingofexercisemetabolismduringgrowthandmaturation.Methodologicallyrobuststudiesusing31P-magneticresonancespectroscopyandoxygenuptakekineticswithchildrenaresparseandsomedataareinconflict.However,itcanbeconcludedthatchildrenrespondtoexercisewithenhancedoxygenutilizationwithinthemyocytecomparedwithadultsandthattheirresponsesareconsistentwithagreaterrecruitmentoftypeImusclefibres.Changesinmusclemetabolismareage,maturation-andsex-relatedanddependentontheintensityoftheexercisechallenge.Theintroductionofexperimentalmodelssuchas"primingexercise"and"work-to-work"transitionsprovideintriguingavenuesofresearchintothemechanismsunderpinningexercisemetabolismduringgrowthandmaturation.