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简介：Thispaperpresentsabidmodelwhichcanbereadilyimplementedinacompetitivebidenvironmentwithintheconstructionindustry.Competitivebidsituationsinvolveamultiplicityofcriteria.Inthispaper,31criteria,whicheffectoptimumestimation,areconsidered.ThemodelisbasedonCBR,thedatabaseofpastcompletedbids,andinformationassociatedwithsuccessfulbids.CBRisconsideredthebestmethodbecauseofthecomplexityoftheconstructiondomainandthewealthofinformationthatthecontractorspossessedonpastbids.

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简介：随着房地产市场的快速发展，上海房地产营销代理业有了长足进步，为繁荣房地产市场作出了贡献，但也存在不少亟待解决的困难和问题。如何规范上海房地产营销代理市场，使之更加有序、健康发展，已成为社会各界关注的热点。尽快建立上海房地产营销代理招投标机制是当务之急。

简介：Bcl-2家族是研究的最早与凋亡相关的因子,发挥抗凋亡或促凋亡的作用,是线粒体凋亡通路中最主要的调节因子。近年来对于Bcl-2家族的研究取得了很大的进展,个别Bcl-2家族成员不仅具有凋亡调节作用,与细胞增殖也密切相关,从而将细胞周期与细胞凋亡偶连。本文较全面地综述了Bcl-2家族中Bcl-2、Bax及Bid三个成员与细胞周期关系的研究新进展。

简介：Twomajorapoptosispathwayshavebeendefinedinmammaliancells,theFas/TNF-R1deathreceptorpathwayandthemitochondriapathway.TheBcl-2familyproteinsconsistofbothanti-apoptosisandpro-apoptosismembersthatregulateapoptosis,mainlybycontrollingthereleaseofcytochromecandothermitochondrialapoptoticevents.However,deathsignalsmediatedbyFas/TNF-R1receptorscanusuallyactivatecaspasesdirectly,bypassingtheneedformitochondriaandescapingtheregulationbyBcl-2familyproteins.Bidisanovelpro-apoptosisBcl-2familyproteinthatisactivatedbycaspase8inresponsetoFas/TNF-R1deathreceptorsignals.ActivatedBidistranslocatedtomitochondriaandinducescytochromecrelease,whichinturnactivatesdownstreamcaspases.Suchaconnectionbetweenthetwoapoptosispathwayscouldbeimportantforinductionofapoptosisincertaintypesofcellsandresponsibleforthepathogenesisofanumberofhumandiseases.