简介：AbstractBackground:Generic drugs are bioequivalent to their brand-name counterparts; however, concerns still exist regarding the effectiveness and safety of generic drugs because of small sample sizes and short follow-up time in most studies. The purpose of this study was to evaluate the long-term antihypertensive efficacy, cost-effectiveness and cardiovascular outcomes of generic drugs compared with brand-name drugs.Methods:In a multicenter, community-based study including 7955 hypertensive patients who were prospectively followed up for an average of 2.5 years, we used the propensity-score-matching method to match the patients using brand-name drugs to those using generic drugs in a ratio of 1:2, 2176 patients using brand-name drugs and 4352 patients using generic drugs.Results:There were no significant differences between generic drugs and brand-name drugs in blood pressure (BP)-lowering efficacy, BP control rate, and cardiovascular outcomes including coronary heart disease and stroke. The adjusted mean (95% confidence interval [CI]) of systolic BP (SBP)-lowering was -7.9 mmHg (95% CI, -9.9 to -5.9) in the brand-name drug group and -7.1 mmHg (95% CI, -9.1 to -5.1) in the generic drug group after adjusting for age, sex, body mass index, number of antihypertensive drugs and traditionally cardiovascular risk factors. Among patients aged <60 years, brand-name drugs had a higher BP control rate (47% vs. 41%; P = 0.02) and a greater effect in lowering SBP compared with generic drugs, with the between-group difference of 1.5 mmHg (95% CI, 0.2-2.8; P = 0.03). BP control rate was higher in male patients using brand-name drugs compared with those using generic drugs (46% vs. 40%; P = 0.01). Generic drugs treatment yielded an average annual incremental cost-effectiveness ratio of $315.4 per patient per mmHg decrease in SBP compared with brand-name drugs treatment.Conclusions:Our data suggested that generic drugs are suitable and cost-effective in improving hypertension management and facilitating public health benefits, especially in low- and middle-income areas.

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简介：聆听CD，划去读出的字母，然后把剩下的字母填在下面的横线上，你会看到纽约的别名。

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简介：Thispaperattemptstoreviewthesemioticstudyofbrands.Duetothevarioustraditionsofsemiotics,theapproachinquestioncontainsseveralwaysofinterpretation,includingstructuralsemioticsandPeirceansemiotics.Formerresearchersmainlyfocusonthefirstmethodandseldomemploythesecondone.Despiteareviewofformerstudies,thispaperalsoputsforwardanewpatternofstudyandpointsoutthesignificanceofthesemioticapproachandqueriesremainedtobesettled.

简介：SANFRANCISCORememberwhencitizenjournalismwasanovelidea?Now,averagepeoplearmedwithvideocameras,laptopsandmobilephonesroutinelycovereverythingfromfloodandfirestoviolenceonthestreetsofMyanmar.Com-binethisdo-it-yourselfmovementwiththeideathateverythoughtandpersonaleventisFacebook-worthy,anditmakessensethatciti-zenmarketingisthenewestformofconsumeractivism-onelookedatbymarketersasapoten-tialholygrail.

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简介：Jingzuobrandqualitymilletisgoldenincolour,plumpingrain,aromaticandsmoothintaste.ItisasicentificandtechnologicalachievementbytheShanxiProvincialAcademyofAgriculturalScience.Themilletcontains15.12%protein,5.67%crudefat,0.28%lysine,multi-vitaminsandmineralelements.Itsnutritionalcompositionisbetterthanothervarieties.Italsohastheeffectofstrengtheningthestomachandspleen,

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简介：TheauthorarguesthatalthoughanewmilitarystrategyofUSArmedForcesisfarfrombeingcompleted,anoutlinehasemerged,thatis,todevelopamilitarystrategysuitablefor'softpowerdiplomacy',ratherthanBush'sstrategyofunilateralismandpreemption.TheauthorthenmakessomeanalysisonthedifficultiesObamaisfacingtofulfillthischange.

简介：ＡＣＨＡＮＧＥＤＮＡＭＥＷＩＴＨＡＮＥＶＯＬＶＩＮＧＦＵＮＣＴＩＯＮ￥ＸｉｅＺｈｅｎｍｉｎｇＯｎＳｅｐｔｅｍｂｅｒ２０．１９９４，ＭｉａｎｚｈｕＣｏｕｎｔｙ，ＳｉｃｈｕａｎＰｒｏｖｉｎｃｅｃｈａｎｇｅｄｔｈｅｎａｍｅｏｆｉｔｓＦａｍｉｌｙＰｌａｎｎｉ...

简介：主编小助理茹越悦：一张设计独到又具特点的漂亮名片，能让你结识许多志趣相投的朋友呢!

简介：在交际英语中,当介绍自己(Introducemyself),问候他人(Greetpeople),询问和告知电话号码(Askforandgivetelephonenumbers)时,往往免不了要简单介绍自己的姓名。我们知道汉语的读音是由汉语拼音构成,书写汉语拼音不标声调的话就与英语字母书写起来一样。究竟怎样用英文书写自己的名字呢?这不,小博士正在给李平解惑呢。

简介：这只可爱的大象，名字和一位印度神的名字相同。聆听光碟，划掉你听到的字母，你便知道大象叫什么名字了！

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简介：QingshanbrandmilkpowderwithteaisproducedbytheInnerMongoliaQingshanMilkHoldingsCo.Ltd.ItispreparedonthebasisoftheoriginaltasteofInnerMongolianmilkwithteaandafolktonicprescription.Thefreshmilkandfinepressedteaareprocessedintoapowderthroughsterilizing,vacuum-condensinganddryspraying.

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