简介:摘要:进入 21世纪以来,高速铁路蓬勃发展。在高速铁路中常用到预制后张法预应力混凝土简支箱梁,其本身特有的 C50高性能混凝土属性是其它混凝土结构无法超越的。本文根据施工现场实际,从预制箱梁配合比设计、原材料控制和施工工艺等方面进行阐述,为预制箱梁施工质量控制提供参考。
简介:[ 摘要 ] 采用膨胀法,结合金相法,测试了实验钢的临界转变点 Ac1 、 Ac3 及 Ms 点。测定了不同冷却温度下轧辊用钢 的膨胀曲线,得到了该材料的连续冷却转变曲线( CCT )。并根据温度对连续冷却转变过程中相转变的影响进行了探讨。
简介:摘要目的探讨肾小球补体C1q及C3c沉积与糖尿病肾病进展的相关性。方法纳入2011年1月至2019年7月在南京医科大学第一附属医院确诊的2型糖尿病肾病患者112例,其中男性83例(74.1%),年龄(51.22±11.12)岁,随访时间19.0(8.5,31.3)个月。根据肾小球C1q和C3c是否沉积分为四组:C1q无沉积C3c无沉积组(n=38)、C1q无沉积C3c沉积组(n=24)、C1q沉积C3c无沉积组(n=14)和C1q沉积C3c沉积组(n=36),检测24 h尿蛋白等临床指标并收集病理资料。采用Cox回归及Kaplan-Meier生存曲线评估肾C1q和C3c沉积对肾脏预后的影响。结果四组间24 h尿蛋白差异有统计学意义[分别为1.84(0.92,3.89),4.19(2.09,6.50)3.30(1.84,6.70),3.64(2.49,7.22)g/24 h,P<0.01],C1q沉积C3c沉积组24 h尿蛋白定量显著高于C1q无沉积C3c无沉积组(P<0.01)。Kaplan-Meier生存曲线结果提示,四组累积生存率差异有统计学意义(Log-rank χ²=8.785,P<0.05),C1q沉积C3c无沉积组累计生存率最低,预后最差。调整后的多因素Cox分析显示,肾小球C1q和C3c共沉积[风险比(HR)2.260,95%可信区间1.329~3.845,P<0.01]、肾小球C1q+C3c+IgM均沉积(HR=4.142,95%可信区间 1.071~16.021,P<0.05)是肾脏预后的独立危险因素。结论肾小球C1q及C3c沉积与糖尿病肾病患者蛋白尿、较差的肾功能和预后不良相关,且肾小球C1q和C3c共沉积是糖尿病肾病进展的独立危险因素。
简介:摘要:目的 分析血液检验标本误差出现的原因,然后据此探讨相应的管理方案。方法 选取2017年12月-2018年13月间的500份血液标本进行回顾性分析,其中共发现误差标本50份。通过分析此50份标本产生误差的原因,然后提出相应的防控措施,提升检验结果的准确性。结果 在50例血液检验标本出现误差原因分析中发现,患者自身的因素、血液采集因素、血液标本送检因素以及血液标本检验因素都是造成血液检验标本误差的重要影响原因。结论 血液检验标准出现误差的影响因素非常多,因此需要强化对血液的管控,提高血液质量,强化防范措施,提升工作人员的工作能力,这样才能够更为有效地提升血液检验的质量。
简介:摘要: 50 米“ 30 人 31 足跑”这项活动对于磨练队员坚强意志、增强团队竞争协作精神有着积极的作用。所以从训练方法、训练技巧、流程优化和竞赛心理等对 30 人 31 足跑进行调查研究是十分有意义和价值的。同时这项多人绑腿集体跑运动也是竞赛项目,运动成绩也尤为重要,本文即以 50 米“ 30 人 31 足跑”训练为研究对象,探索恰当的训练方法,并形成该小专题。
简介:[摘要]:目的:分析 50例儿童失神癫痫脑电图波形典型改变特征及儿童失神癫痫的临床发作特点。方法:对我院 2015年 -2019年 50例儿童失神癫痫收集的资料进行回顾性分析。结果: 50例儿童失神癫痫异常率达 100%。结论:发作期为双侧对称、同步的 3Hz棘慢综合波或双棘慢综合波节律爆发,棘慢综合波的频率在发作期开始时稍快,平均为 3.5-4.5Hz;结束前稍慢,可达 2.5-2.8Hz,波幅以前头部最高,持续约 4-20秒,多数在 8-10秒之间,发作后背景无抑制或波率慢化现象。过度换气试验容易诱发出临床发作。
简介:AbstractBackground:Aberrant activation of the complement system plays an important role in the pathogenesis and development of immunoglobulin A nephropathy (IgAN). The relationship between serum complement and the clinical-histopathological features and outcomes of IgAN is controversial. This retrospective study aimed to examine the relationship between the complement 3/4 (C3/C4) ratio and the clinicopathologic changes and prognosis of patients with IgAN.Methods:A total of 397 patients with primary IgAN from January 2007 to December 2012 at the Chinese People’s Liberation Army General Hospital were included in this study. The correlation test and Chi-square test or one-way analysis of variance test were performed to evaluate the relationship between the C3/C4 ratio and other clinical-pathological factors. Propensity score matching and a multivariate Cox regression model were used to calculate the risk factors of renal outcome.Results:The median follow-up period was 75 months. During the follow-up period, 62 patients (15.6%) developed into the end-stage renal disease (ESRD). The C3/C4 ratio at baseline was associated with the level of serum creatinine (SCr), 24 h urinary protein excretion (24 h Upre), global glomerular sclerosis, and tubulointerstitial lesion. The level of SCr and 24 h Upre and the degree of chronic kidney injury were statistically different among groups defined by different C3/C4 ratio levels. The survival rates of patients among groups with different C3/C4 ratio levels were different. After propensity score matching, eighty-eight pairs of patients were successfully matched, and the C3/C4 ratio was an influencing factor for the patients’ outcome (hazard ratio 0.587, 95% confidence interval 0.329-0.880). Patients with a C3/C4 ratio <3.6 had a poorer outcome compared with the others (P = 0.002).Conclusions:IgAN patients with decreased C3/C4 ratio displayed significantly more severe clinical symptoms and chronic renal injury than patients with higher ratios. A low C3/C4 ratio could be a risk factor for patients developing to ESRD.
简介:摘要: 火电厂在实际运行的过程中,最容易发生故障的类型就是电气设备故障,基于此,本篇文章主要对电气设备故障以及实际的故障处理方法进行深入的探究和分析。
简介:摘要目的分析1个诺里病家系的致病基因变异,确定其遗传学病因。方法对先证者核心家系4名成员的DNA样本进行全外显子组检测,筛选变异位点,确定致病基因。通过Sanger测序对核心家系及7名其他家系成员进行验证。结果全外显子组检测及Sanger测序结果显示先证者及另外3例男性患者的NDP基因均存在c.361C>T(p.Arg121Trp)半合子错义变异,先证者母亲、外祖母和2个表妹均为c.361C>T杂合变异携带者,正常表型男性家系成员均未检测到该变异,符合X连锁隐性遗传病的特点。结论NDP基因c.361C>T错义变异是该诺里病家系的遗传学病因。
简介:AbstractBackground:Developing effective spinal cord repair strategies for spinal cord injury (SCI) is of great importance. Emerging evidence suggests that microRNAs (miRNAs) are closely linked to SCI recovery. This study aimed to investigate the function of miR-34c in the neuronal recovery in rats with SCI.Methods:A rat model with SCI was established. Differentially expressed miRNAs were identified by a microarray analysis. MiR-34c expression in rats was measured by reverse transcription quantitative polymerase chain reaction. Altered expression of miR-34c or C-X-C motif ligand 14 (CXCL14) was introduced in SCI rats to measure their roles in neuronal recovery. Western blot analysis was performed to determine the phosphorylation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription-3 (STAT3). Neuronal apoptosis in rat spinal cord tissues was detected. The concentrations of SCI recovery-related proteins thyrotropin releasing hormone (TRH), prostacyclin (PGI2), and ganglioside (GM) were evaluated by enzyme-linked immunosorbent assay. Data were analyzed using a t-test with a one-way or two-way analysis of variance.Results:Rats with SCI presented decreased grip strength (112.03 ± 10.64 vs. 17.32 ± 1.49 g, P < 0.01), decreased miR-34c expression (7 days: 3.78 ± 0.44 vs. 0.95 ± 0.10, P < 0.05), and increased CXCL14 expression (7 days: 0.61 ± 0.06 vs. 2.91 ± 0.27, P < 0.01). MiR-34c was found to directly bind to CXCL14. Overexpression of miR-34c increased grip strength (11.23 ± 1.08 vs. 31.26 ± 2.99 g, P < 0.01) and reduced neuronal apoptosis in spinal cord tissues (53.61% ± 6.07% vs. 24.59% ± 3.32%, P < 0.01), and silencing of CXCL14 also increased the grip strength (12.76 ± 1.13 vs. 29.77 ± 2.75 g, P < 0.01) and reduced apoptosis in spinal cord tissues (55.74% ± 6.24% vs. 26.75% ± 2.84%, P < 0.01). In addition, miR-34c upregulation or CXCL14 downregulation increased the concentrations of TRH, PGI2, and GM, and reduced phosphorylation of JAK2 and STAT3 in rats with SCI (all P < 0.01).Conclusion:The study provided evidence that miR-34c could promote neuronal recovery in rats with SCI through inhibiting CXCL14 expression and inactivating the JAK2/STAT3 pathway. This study may offer new insights into SCI treatment.
简介:摘要目的分析非牧区布鲁菌病患者的临床特征、治疗及预后情况,以提高非牧区布鲁菌病的认识和诊疗水平。方法对山东大学附属济南市传染病医院2019年8-9月收治的布鲁菌病患者50例的流行病学资料、临床表现、免疫学检查、血培养及影像学检查、治疗等进行回顾性分析。结果50例患者中成年人48例,儿童2例;年龄范围26~84岁,年龄最小为2岁7个月,最大84岁;男性41例,女性9例;临床表现以发热、多汗、腰痛、局部脓肿为主。红细胞沉降率增快29例;试管凝集试验阳性(1∶200)48例,阴性2例;血培养阳性14例,表现为针尖样菌落;26例行磁共振检查,骨和周围累及的软组织有异常信号。50例患者确诊后,行对症治疗和抗菌治疗,48例痊愈,2例局部脓肿局限。结论非牧区布鲁菌病表现多样,易误诊,对可疑患者进行布鲁菌凝集试验检查、血培养及磁共振检查有助于诊断;对症治疗和抗菌治疗预后良好。