简介：AIM:Toexaminetheintegrityoftheocularsurfacesofsubjectswithandwithoutdiabeteswithnoconjunctivalanddryeyesignsandsymptomsandcompareconjunctivalimpressioncytologyfindingsindiabeticswithnon-proliferativeandproliferativediabeticretinopathy.METHODS:Conjunctivalimpressioncytologywasperformedon43eyesof43subjectswithnonproliferativediabeticretinopathy(NPDR),42eyesof42subjectswithproliferativediabeticretinopathy(PDR),and30eyesof30controlsubjects.Impressioncytologyspecimensofeachgroupweregradedandscoredintherange0-3accordingtoNelson’smethod.RESULTS:Therewere45(52.9%)womenand40(47.1%)men.Themeanageofthepatientswas59.6±9.3y(range,43-76y)inNPDRgroupand58.0±8.8y(range,41-85y)inPDRgroup.CaseswithNPDRandPDRshowedstatisticallysignificanthigherimpressioncytologyscoresthancontrolgroup(P<0.05).TherewasnodifferencebetweentheNPDRandPDRpatientsforimpressioncytologygradingscores.CONCLUSION:ItisdeterminedthatimpressioncytologygradesarealteredinpatientswithNPDRandPDR.Consequently,wesuggestthattheremightbeanassociationbetweentheimpressioncytologygradingscoresandtheseverityofdiabeticretinopathy

简介：AIM:Toinvestigateandcomparethecytopathologicalandclinicaleffectsofamnioticmembranetransplantation(AMT)andoralmucosalmembranetransplantation(OMMT)insocketcontraction.METHODS:Twelvepatientswhocouldnotbefittedwithocularprosthesisduetosocketcontracturewereincludedinthisstudy.SevenpatientsunderwentAMTand5patientsunderwentOMMT.Thirteenpatientswhohadhealthysocketswereincludedascontrolgroup.Depthofinferiorfornix,degreeofinflammation,extentofthesocketcontractureandsocketvolumeweremeasuredinthepreoperativeperiodandatsixthandtwelfthweekspostoperatively.Impressioncytologyofconjunctivalfornicesandteartransforminggrowthfactorbeta-1(TGFβ1)levelsweredetermined.RESULTS:IntheAMTgroup,socketvolumeandlowerfornixdepthvaluesweresignificantlyhigher(P=0.030andP=0.004respectively)andinflammationlevelsandimpressioncytologystages(P=0.037andP=0.022respectively)weresignificantlylowerinpostoperativeperiodcomparedtopreoperativeperiod.IntheOMMTgroup,nostatisticaldifferenceswerefoundintermsofclinicalparameters,inflammationlevelsandimpressioncytologystagesofpreoperativeversuspostoperativevalues.PreoperativetearTGFβ1levelswerehigherinAMTandOMMTgroupscomparedtothecontrolgroup(25.5ng/mL,26.3ng/mLand21.7ng/mLrespectively).DecreasedtearTGFβ1levelswereobservedinboththeAMTandOMMTgroupspostoperatively(mediandecreasevalue=2.1ng/mLand2.7ng/mLrespectively).CONCLUSION:AMTisassociatedwithpostoperativeimprovementininferiorfornixdepth,socketvolume,inflammationandimpressioncytologylevelsandmaybeamoreproperalternativemethodthanOMMTinthemanagementofsocketcontracture.