简介：Blanketsandotherin-vesselcomponentsareeasilydamagedowingtotheircircumstanceofhighradiationandhighheat.Toprotectthem,firstwalldesignshouldbeconsidered.Owingtoitshighheatremovalndself-refreshingcapability,liquidmetalfirstwallhasbeenseenasapotentialfirstwallforafusionreactorinthefuture.Blanketliquidcurtainisactuallyaspecialliquidmetalwalltoprotectblanket.

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简介：contourstressofspine,parallelogram,cervicalflexure,lumbarflexure,boundaryregioninspinalmechanics,neutralzone,thefirstclasslever

简介：M. H. 1985. Input and Second Language Acquisition Theory. In S. M. Gass &,4.F15 I wish,Though I gave a recast in turn 3

简介：很少信息都不在土壤酶活动的潜力上存在，它是敏感的玷污性质和管理，为在集水规模的沉积来源的描述。这研究的目的是为沉积在Hiv集水(55km2)采指纹作为tracer探索并且评估酶活动，伊朗。因此，四酶从水库检查水坝(沉积水池)从42个不同采样地点，以及从12件沉积样品被测量，盖住三个沉积来源区域(牧场/表面侵蚀，果园/表面侵蚀，和streambank侵蚀)。结果显示那，在向后的模式判别式分析，-glucosidase和脱氢酶之上基于，允许正确地要分到他们的来源区域的超过95%样品。这些酶作为输入数据被选择让一个混合模型决定取样的沉积来源的相对贡献。从在学习区域的牧场，果园和streambank来源的吝啬的贡献分别地作为11.3%，15.1%和73.7%被估计。用geochemicaltracers，从牧场的吝啬的贡献，果园和streambank，来源分别地作为14.1%，9.5%和74.8%被估计。联合生物化学并且geochemicaltracers，类似的价值被获得(18.7%，10.7%和70.7%，分别地)。我们的结果显示那项土壤酶活动允许沉积来源的好描述，和罐头提供一个互补工具给当前存在的沉积采指纹途径。然而，方法应该也在另外的区域被测试。

简介：which focuses on error correction and the learners’affect.,which help the students’ language learning by correcting their errors and providing positive support to students’ affect as well.,method. Positive feedbacks are provided before and after negative feedback to create a warm climate for error correction in classroom and encourage students to produce more output without fear of making errors.

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简介：识别蛋白质的细胞的本地化是的潜水艇在基因产品的功能的注解特别地有用。在这研究，我们使用机器学习和探索数据分析(EDA)技术检验并且描绘在九细胞的分隔空间局部性的人的蛋白质的氨基酸序列。代表人的蛋白质的3,749个蛋白质序列的数据集从SWISS-PROT数据库被提取。特征向量被创造捕获特定的氨基酸顺序特征。相对一台支持向量机器，一个多层的视感控器，和一个天真的Bayes分类器，C4.5决定树算法是越过在可靠地预言蛋白质的细胞的本地化基于他们的氨基酸定序的潜水艇的所有九分隔空间的最历久不渝的表演者(平均Precision=0.88；平均Sensitivity=0.86)。而且，EDA图形在每分隔空间描绘了蛋白质的必要特征。作为例子，在血浆膜上局部性的蛋白质有恐水病的氨基酸的更高的比例；细胞质的蛋白质有中立氨基酸的更高的比例；并且mitochondrial蛋白质有中立氨基酸的更高的比例和极的氨基酸的更低的比例。这些数据证明C4.5分类器和EDA工具能为描绘并且预言人的蛋白质的细胞的本地化基于他们的氨基酸定序的潜水艇是有效的。

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简介：WithInternetchangingtheluxurybusinesslandscape,newplayershaveemergedsuchastheOnlinePrivateSalesRetailers(OPSRs).Theseofferonlinebuyerswithachoiceoflimited-timesalestohelpcompaniesgetridoftheiroverstocks.Luxurybrandsarenoexception.Noresearchhasbeenconductedabouthowluxuryconsumersrelatewithsuchwebsites,hencethispaper.Inanexploratoryfashion,interviewswithluxurybuyerswhoalsobuyonlineonOPSRs,areconductedtogetinsightsonconsumers’perceptionsandluxurybrandequitythatsellingthroughOPSRsmayhave.Wefindthatappropriateproductandbrandhelpconsumersforgetthattheyarebuyingbrands’unsoldstocks,thattransferringtheluxurywebmosphereswouldbepositivelyperceived,thatconsumersfromthesewebsitesarelookingforbenefitssuchasfreedomofuseandbranddiscovery,ratherthanpersonalizedoffers,thatmultiplediscountsonseveralOPSRsmaydamagetheluxury-perceptionofabrand,thattheprivatesalesmembersconsidertheservicetobegoodenoughforthedemandedprice,andthatpersonalizedinvitationscanhelpincreaseonlineconsumers’feelingsofdesirabilityandexclusivity.ThepaperconcludeswithpracticalrecommendationsforbothluxurycompaniesandOPSRs.

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简介：Basedonthespatialeconomytheoryandtheexploratoryspatialdataanalysis(ESDA)technology,thispa-perstudiesthespace-timedynamicsofregionalpercapitaGDPintheYangtzeDelta.Asampleof74regionsintheYangtzeDeltaovertheperiodof1994to2004providesclearevidenceofglobalandlocalspatialautocorrelationaswellasspatialheterogeneityinthedistributionofregionalpercapitaGDP.Thedynamismofregionsisinvestigatedbyexploringthespatialpatternofregionalgrowth,comparedwiththatbefore1997,theeconomicgrowthdisparitiesamongShanghai,ZhejiangandJiangsuprovinceshavedecreased,sohavetheinsideregionsofZhejiangProvince,whileitisoppositetotheinsideregionsofJiangsuProvince.

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简介：AbstractBackground:Air pollution and poor ambient air quality are significantly related to multiple health risks. One associated disease is chronic obstructive pulmonary disease (COPD), a preventable disease with several contributing factors and one of the leading causes of morbidity/mortality locally and globally. A potentially high-risk population are traffic enforcers who are constantly exposed to air pollution. In the Philippines, the MMDA has the widest coverage in traffic management. The study determined the risk of COPD among Metro Manila Development Authority (MMDA) traffic enforcers in relation to ambient air quality level, as well as identified other factors that increase the risk of developing COPD.Methods:Fifty-two MMDA traffic enforcers deployed in PM2.5 air quality sensor areas in Metro Manila from 2016 to 2018 were recruited through stratified sampling. The International Primary Airways Guidelines (IPAG) questionnaire was utilized to measure risk of COPD. Respiratory health and working history were obtained through questionnaires. Department of environment and natural resources provided PM2.5 ambient air quality data which aided in the construction of the Exposure-Month Index. Ordinal logistic regression was used to examine the association of PM2.5 together with the relevant factors and the risk of COPD.Results:We found statistically significant associations between PM2.5 and COPD among high risk category [odds risk (OR): 1.24, 95% confidence interval (CI): 1.07-1.44]. Age (Moderate, OR: 1.16, 95% CI: 0.98-1.38 and High, OR: 10.06, 95% CI: 4.02-25.17) and chest pain (Moderate, OR: 68.65, 95% CI: 1.71-2.75 × 103) were potential risk factors, whereas body mass index (BMI) (OR: 0.05, 95% CI: 0.01-0.53) exhibited protective effect.Conclusions:Exposure to PM2.5 was associated with an increased risk of COPD among high-risk category MMDA traffic enforcers. Age and chest pain were potential risk factors to risk of COPD, whereas BMI exhibited a potential protective effect. Results of this study can be used for clinical management of high-risk populations, such that of MMDA traffic enforcers.

简介：Objective:Therecurrenceorprogressionunderendocrinetherapyinhormonereceptor-positive(HR+)advancedbreastcancer(ABC)remainedacriticalclinicalchallenge.Chidamideisanoralsubtype-selectivehistonedeacetylase(HDAC)inhibitorwithmultiplefunctionsintumorgrowthinhibitionandmicroenvironmentmodulationviaepigeneticreprogramming.Thepurposeofthisstudywastoevaluatethesafety,pharmacokinetics(PK),andpreliminaryefficacyofchidamideincombinationwithexemestaneinHR+ABCpatients.Methods:EligiblepatientswerepostmenopausalwomenwithHR+ABCrecurrentorprogressedtoatleastoneendocrinetherapy.Bloodsampleswereobtainedintherun-inperiodandthefirstdayofcombinationtreatmentforPKanalysis.Incombinationtreatment,patientsweregivenexemestane25mgdailyandchidamide30mgtwiceaweek(BIW)untilprogressionofdiseaseorintolerabletoxicities.Atreatmentcyclewasdefinedas4weeks.Safety,PKparameters,andpreliminaryefficacywereevaluated.Results:Atotalof20patientswereenrolledbetweenJulyandDecember,2015.Themediannumberoftreatmentscyclewas5.2(20.8weeks)with2patientsstillontreatmentatthedatacut-offdateofOctober,2017.Thetreatment-relatedadverseevents(AE)≥grade3inmorethan2patientswereneutropenia(35%),thrombocytopenia(30%),andleucopenia(20%).Theplasmaexposureofexemestanewasconsistentinthepresenceorabsenceofchidamide.Aslightincreaseinchidamideexposurewasnotedinthepresenceofexemestane,probablyduetotheinter-andintra-patientvariations.Thebestresponsein16evaluablepatientswasassessedbyResponseEvaluationCriteriainSolidTumors(RECIST),including4patientswithpartialresponse,10patientswithstabledisease.Themedianprogression-freesurvival(PFS)was7.6months.Conclusions:ThecombinationofchidamidewithexemestanewasgenerallywelltoleratedwithpromisingpreliminaryefficacyinHR+ABCpatients.Theoverallresultsfromthisstudyencouragefurtherpivotaltrialinthispatie