简介：

简介：ＴＣＥＬＬＲＥＣＥＰＴＯＲＧＥＮＥＲＥＡＲＲＡＮＧＥＭＥＮＴＡＮＡＬＹＳＩＳＩＮＴＨＥＰＲＩＭＡＲＹＣＵＴＡＮＥＯＵＳＴＣＥＬＬＬＹＭＰＨＯＭＡＱｉｕＢｉｎｇｓｅｎ邱丙森ＷａｎｇＰｉｎｇ１王平ＧａｏＨｏｎｇｙａｎｇ２高红阳ＳｈａｎｇＹｉｆｅｉ２...

简介：Minimalresidualdisease(MRD)playsacausativeroleintumorrecurrenceandestablishmentofeffectiveandsensitiveassessmentofMRDcouldbeveryusefulforstagingandevaluationoftreatmentofdisease.Inthisstudy,weassessedtheusefulnessofhcf-2/JHPCRanalysisonoccultlymphoma...

简介：Inthispaper,someinequalitiesforsequencerearrangementandmatrixproductareestablished.Theauthorsextendandimprovesomeknownresults,andshowthattherearesomeerrorsinreferenceoninequalitiesforsequencerearrangementbyexamples,

简介：

简介：

简介：Severalbisabolanesesquiterpenes,(±)-curcumene,(±)-curcuphenol,(±)-curcudioland(±)-curcuhydroquinone,havebeensynthesizedinracemicformandfullycharacterized.ThesalientcharacteristicofourapproachisthataJohnson-Claisenarrangementwasinvolvedasakeystep.

简介：

简介：ObjectiveThestudyistoidentifythecarrierrateofcommondeafnessmutationinChinesepregnantwomenviadetectingdeafnessgenemutationswithgenechip.MethodsThepregnantwomeninobstetricclinicwithouthearingimpairmentandhearingdisordersfamilyhistorywereselected.Theinformedconsentwassigned.PeripheralbloodwastakentoextractgenomicDNA.Applicationofgeneticdeafnessgenechipfordetecting9mutationalhotspotofthemostcommon4Chinesedeafnessgenes,namelyGJB2(35delG,176del16bp,235delC,299delAT),GJB3(C538T),SLC26A4(IVS72A>G,A2168G)andmitochondrialDNA12SrRNA(A1555G,C1494T).Furthergenetictestingwereprovidedtothespousesandnewbornsofthescreenedcarriers.ResultsPeripheralbloodof430pregnantwomenweredetected,detectionofdeafnessgenemutationcarriersin24cases(4.2%),including13casesoftheGJB2heterozygousmutation,3casesofSLC26A4heterozygousmutation,1casesofGJB3heterozygousmutation,and1caseofmitochondrial12SrRNAmutation.18spousesand17newbornstookfurthergenetictests,and6newbornsinheritedthemutationfromtheirmother.ConclusionThecommondeafnessgenesmutationhasahighcarrierrateinpregnantwomengroup,235delCandIVS7-2A>Gheterozygousmutationsarecommon.

简介：

简介：Genestellcellswhattodo,forexample,whentorepairDNAmistakesorwhentodie,andcanbeturnedonorofflikealightswitch.Knowingwhichgenesareswitchedon,orexpressed,isimportantforthetreatmentandmonitoringofdisease.Now,forthefirsttime,Researchersinthelaboratoryof

简介：Wehavereviewedthegenetherapyingastrointestinaldiseases^[1].GastriccanceriscommoninChina^(2-20),anditsearlydiagnosisandtreatmentarestilldifficultuptonow^(13-36).Theex-pressionofanexogenousgeneintroducedbygenetherapyintopa-tientswithgliomascanbemonitorednon-invasivelybypositron-emissiontornography^[4].

简介：Objective:TostudythechangesofthegeneexpressionpatternofspinalcordtissuesintheearlystageafterinjurybyDNAmicroarray(genechip).Methods:ThecontusionmodelofratspinalcordwasestablishedaccordingtoAllen'sfallingstrikemethodandthegeneexpressionpatternsofnormalandinjuredspinalcordtissueswerestudiedbygenechip.Results:Theexpressionof45geneswassignificantlychangedintheearlystageafterspinalcordinjury,inwhich22genesup-regulatedand23genesdown-regulated.Conclusions:Theexpressionofsomegeneschangessignificantlyintheearlystageafterspinalcordinjury,whichindicatesthecomplexityofsecondaryspinalcordinjury.

简介：客观；在忍受肝癌症的老鼠调查鼠科的IL-12基因和HSV-TK基因治疗的synergistic反肿瘤效果。方法：老鼠肝癌症MM45T李(H-2d)房间是有包含IL-12基因或HSV-TK基因的retroviral向量的transfected插入修改基因的肝癌症房间，MM45TLi/IL-12和MM45TLi/TK，与IL-12和TK的稳定的表示被获得。Balb/c老鼠与2X105MM45T李房间皮下地被接种。当肿瘤到达了0.5鈥?.0厘米的一种尺寸时，MM45T.Li/TK房间的混合物照耀and60Co的MM45TLi/IL-12房间intratumoraly被注射。Ganciclovir(GCV)是注射ip(40mg.kg?1.d?1)为10天。Intratumoral注射照耀of60Co的MM45TLi/IL-12房间分开在一个星期内被重复两次。有远肿瘤的老鼠根据一样的协议被对待。怒气房间的CTL活动是测量by51Cr版本试金和由染色的immunohistochemical渗入淋巴细胞的肿瘤的显型。结果：在与MM45T对待的老鼠，Li/IL-12或MM45TLi/TK+GCV个别地在肿瘤生长，而是两个都不导致了中等减小能根除肿瘤完全，当时在加GCV与MM45TLi/IL-12和MM45TLi/TK细胞的混合物对待的60%老鼠，完全的肿瘤回归被观察，没有为二个月的肿瘤复发。远肿瘤的生长也在同样对待的老鼠显著地被禁止。大多数收到的老鼠加GCV联合了基因治疗有的丰富的CD4+，CD8+T淋巴细胞渗入。他们的CTL活动比在老鼠显著地高收到的单个基因治疗。有加GCV的IL-12基因和HSV-TK基因的结论联合治疗为老鼠肝癌症是有效的。

简介：ＳＴＵＤＹＯＮＴＨＥＲＥＡＲＲＡＮＧＥＭＥＮＴＲＥＡＣＴＩＯＮＯＦ５－ＡＭＩＮＯ－１－ＡＭＩＮＯＣＡＲＢＯＮＹＬ－１，２，ＡＮＤＩＴＳＡＮＡＬＯＧＵＥＳ￥ＲｏｎｇＪｉａｎＬＵ；ＨｕａＺｈｅｎｇＹＡＮＧ；ＢａｏＹｉｎｇＱＩＡＮ；ＨａｉＹａｎＤＥＮＧ（Ｎ...

简介：MicroRNAs(miRNAs)是他们在植物和动物的目标基因的重要post-transcriptional管理者。miRNAs通常长是20-24核苷酸。尽管有他们的不平常地小的尺寸，miRNA基因家庭的进化历史似乎类似于编码theirprotein对应物。与在动物染色体的小却丰富的miRNA家庭相对照，植物有少数但是更大的miRNA基因家庭。植物miRNA基因家庭的成员经常是高度类似的，建议经由双人脚踏车基因复制和部分复制事件的最近的扩大。尽管许多miRNA基因越过植物种类被保存，一样的基因家庭在不同种类在尺寸和genomic组织显著地变化，它可以在目标基因规定引起剂量效果和空间、时间的差别。在这评论，我们在理解植物miRNA基因家庭的进化总结当前的进步。

简介：ＥＬＥＭＥＮＴＡＬＳＴＵＤＹＯＦＧＥＮＥＴＨＥＲＡＰＹＷＩＴＨＴＨＲＯＭＢＯＰＯＩＥＴＩＮＬｕＣｈｅｎｇｒｏｎｇ陆承荣ＺｈａｏＪｉａｎｚｅｎｇ赵建增ＷａｎｇＸｉａｏｐｉｎｇ王小平Ｌｉｕｌｉ刘丽ＲｅｓｅａｒｃｈＣｅｎｔｅｒｏｆＭｏｌｅｃｕｌａｒＢｉｏｌ...

简介：Duetoconcernsregardingtheoverlappingfiguresinthisreviewthatareidenticaltothosecontainedinareviewarticlethatwehaveco-authoredandpublishedearlier,weretracttheabovepaperwepublishedinCellResearch.Weapologizeforanyconfusionthatmaybecausedbythismatter,althoughwestandbythescientificcontentscontainedintheCellResearchpaper.

简介：Asearlyas2000yearsago,ancientChinesemedicalrecordshaddescribedtherelationshipbetweendiseasesandappearanceindetail.Moreover,modernmedicinehasalsoconstantlystudiedtherelationshipbetweenfacialfeaturesandhealthinevolutionaryterms.Itiswellknownthatmanyhereditarydiseasesinvolvecertainabnormalfacialfeaturesandgenemutations.Thetumorisalsoconsideredasgeneticdisordertosomeextent,sowhatistherelationshipbetweencancergeneticsandcongenitaldevelopmentoffacialfeatures?Here,wereviewedsomecluestotheappearance-gene-tumorrelation,whichmightbecomethetargetsintheearlypreventionorgenetherapyofcancerinthefuture.Thissummaryprovidedusanewstrategyforthecancergeneticscreeningandanewresearchdirectionforgeneticdiagnosisofthepotentialdisease.

简介：Directgenetransferintosomatictissueinvivoisadevelopingtechnologywithpotentialapplicationforcancergenetherapy.Retrovirusvector,whichwasaneffectivevehicle,stillhassomedisadvantagesingeneratinghightiterrecombinantvectorsandmanipulatingtomediateinvirogenetransfer.Inthispaper,recombinantvacciniavirusvectorencodinghuman