简介:在Tikhonov正则化方法的基础上将其转化为一类l1极小化问题进行求解,并基于Bregman迭代正则化构建了Bregman迭代算法,实现了l1极小化问题的快速求解.数值实验结果表明,Bregman迭代算法在快速求解算子方程的同时,有着比最小二乘法和Tikhonov正则化方法更高的求解精度.
简介:目的分析青岛地区不同宫颈病变组织中人乳头瘤病毒(HPV)16型L1基因序列的多态性,探讨其序列变异与宫颈癌的相关性。方法提取2008年6月至2010年5月青岛大学医学院附属医院妇产科61例宫颈癌组织和181例宫颈脱落细胞DNA,采用PCR技术筛选HPV16阳性标本,进而对其L1基因全长进行扩增、测序,应用DNASTAR软件进行序列比对,分析核苷酸和氨基酸的变异。结果慢性宫颈炎组、宫颈上皮内瘤变(CIN)组和宫颈癌组HPV16的感染率分别为30.0%(12/40)、41.1%(58/141)和65.6%(40/61),3组比较,差异有统计学意义(P〈0.05)。共有96例成功扩增出HPV16L1基因,慢性宫颈炎、CIN和宫颈癌组扩增率分别为25.0%(10/40)、37.6%(53/141)和54.1%(33/61)。HPV16型L1基因共发现13处变异,宫颈癌组织均发生C6240G、A6432G、6902insATC、6954delGAT及G7061A(无义)5处突变,另一突变热点为A6178C,但其在慢性宫颈炎、CIN、宫颈癌组的频率分布比较,差异无统计学意义(P〉0.05)。结论青岛地区HPV16L1基因的多态性具有地域性,可能导致病毒地方株的免疫原性和抗原性改变,但与宫颈癌的发生发展无明显关系。
简介:目的检测人乳头瘤病毒(HPV)L1壳蛋白在宫颈上皮内瘤变(CIN)患者宫颈脱落细胞中的表达,以寻求预测CIN的生物学标志物。方法收集2008年12月至2011年8月在河南省漯河市中心医院有指征行阴道镜活检患者的宫颈脱落细胞标本480例,采用免疫细胞化学法检测HPVL1壳蛋白的表达。结果480例患者HPVL1壳蛋白的总阳性率为40.2%(193/480),其中正常/慢性宫颈炎、CIN1、CIN2、CIN3和宫颈鳞状细胞癌(SCC)HPVL1壳蛋白的阳性表达率分别为40.5%(17/42)、66.2%(131/198)、26.4%(28/106)、17.3%(17/98)和0(0/36)。其中CIN1组、SCC组与正常/慢性宫颈炎组,CIN1组与CIN2/3组,CIN1、CIN2/3组与SCC组HPVLI壳蛋白阳性表达率比较,差异均有统计学意义(P均<0.01)。结论HPVL1壳蛋白在宫颈上皮内瘤变中的阳性表达随病变程度的加重而呈下降趋势,提示其有望成为预测宫颈癌前病变程度的标志物。
简介:Inthispaperwewillshowthatifanapproximationprocess{Ln}n∈Nisshapepreservingrelativetotheconeofallk-timesdifferentiablefunctionswithnon-negativek-thderivativeon[0,1],andtheoperatorsLnareassumedtobeoffiniterankn,thentheorderofconvergenceofDkLnftoDkfcannotbebetterthann2evenforthefunctionsxk,xk+1,xk+2onanysubsetof[0,1]withpositivemeasure.Takingintoaccountthisfact,wewillbeabletofindsomeasymptoticestimatesoflinearrelativen-widthofsetsofdifferentiablefunctionsinthespaceLp[0,1],p∈N.
简介:Aseriesofnovel1H-benzimidazol-1-ylacetatesand1H-benzimidazol-1-ylpropionatescontaining1H-1,2,4-triazolemoietyweresynthesizedundermicrowaveirradiationbymulti-stepreactions,inyieldsof87-94%.TheirinvitroantifungalactivitiesagainstBotrytiscinereaandSclerotiniasclerotiorumwereevaluatedbymycelialgrowthratemethod.AllthetargetcompoundsexhibithighactivitiesagainstB.cinereawiththeEC50valuesof7.96-21.74μg/mL,higherthanthatofcarbendazim.
简介:Basedondatacollectedfromatemporalseismicnetwork,andinadditiontothedatafromsomenearbypermanentstations,weinvestigatethevelocitystructureandseismicityintheRongchanggasfield,wheresignificantinjection-inducedseismicityhasbeenidentified.First,weusereceiverfunctionsfromdistantearthquakestoinvertdetailed1-Dvelocitystructuresbeneathtypicalstations.Then,weusethedouble-differencehypocenterlocationmethodtore-locateearthquakesofthe2010ML5.1earthquakesequencethatoccurredintheregion.There-locatedhypocentersshowthatthe2010ML5.1earthquakesequencewasdistributedinasmallareasurroundingmajorinjectionwellsandclusteredmostlyalongpre-existingfaults.Majorearthquakesshowafocaldepthlessthan5kmwithadominantdepthof~2km,adepthofmajorreservoirsandinjectionwells.Wethusconcludethatthe2010ML5.1earthquakesequencemighthavebeeninducedbythedeepwellinjectionofunwantedwateratadepth~3kmintheRongchanggasfield.
简介:让f(z)是为完整的模块化的组的重量k的holomorphicHeckeeigencuspform。让f(n)是f(z)的第n个规范的Fourier系数。建议那L(sym2f,s)对称的方形的L功能与f(z)被联系,并且$\lambda_{sym^2f}(n)$(n)表示第n系数L(sym2f,s)。在这份报纸,它被证明那$$\sum\limits_{n\leqslantx}{\lambda_{sym^2f}^4(n)}=xP2(\logx)+O(x^{\frac{{79}}{{81}}+\varepsilon}),$$,在P2(t)是在度2的t的一个多项式的地方。同样,它被获得那$$\sum\limits_{n\leqslantx}{\lambda_f^4(n^2)}=x\tildeP2(\logx)+O(x^{\frac{{79}}{{81}}+\varepsilon}),$$,在哪儿$\tildeP_2(t)$是在度2的t的一个多项式。
简介:LetAbead×drealexpansivematrix.AnA-dilationParsevalframewaveletisafunctionψ∈L2(Rd),suchthattheset{|detA|n/2ψ(Ant-l):n∈Z,l∈Zd}formsaParsevalframeforL2(R~d).AmeasurablefunctionfiscalledanA-dilationParsevalframewaveletmultiplieriftheinverseFouriertransformoff■isanA-dilationParsevalframewaveletwheneverψisanA-dilationParsevalframewavelet,where■denotestheFouriertransformofψ.Inthispaper,theauthorscompletelycharacterizeallA-dilationParsevalframewaveletmultipliersforanyintegralexpansivematrixAwith|det(A)|=2.Asanapplication,thepath-connectivityofthesetofallA-dilationParsevalframewaveletswithaframeMRAinL2(Rd)isdiscussed.
简介:Poly(4-vinylpyridine)supportednanoparticleofcopper(Ⅰ)iodideisreportedasagreenandrecyclablecatalystfortheregioselectivesynthesisof1,4-disubstituted-1H-1,2,3-triazolesfrombenzylhalides,sodiumazideandterminalalkynesinwater.Thiscatalystcanberecoveredbysimplefiltrationandrecycledupto8consecutiverunswithoutanylossofitsefficiency.
简介:Inthisarticle,weshowthatifXisanexcellentsurfacewithrationalsingularities,theconstantsheafQeisadualizingcomplex.IncoefficientZe,wealsoprovethattheobstructionforZetobecomeadualizingcomplex,liesonthedivisorclassgroupsatsingularpoints.Asapplications,westudytheperversesheavesandtheweightsof-adiccohomologygroupsonsuchsurfaces.