简介：Accuratediagnosisoftumorsneedsmuchdetailedinformation.However,availablesingleimagingmodalitycannotprovidecompleteorcomprehensivedata.Nanomedicineistheapplicationofnanotechnologytomedicine,andmultimodalityimagingbasedonnanoparticleshasbeenreceivingextensiveattention.Thisnewhybridimagingtechnologycouldprovidecomplementaryinformationfromdifferentimagingmodalitiesusingonlyasingleinjectionofcontrastagent.Inthisreview,weintroducerecentdevelopmentsinmultifunctionalnanoparticlesandtheirbiomedicalapplicationstomultimodalimagingandtheragnosisasnanomedicine.Mostofthereviewedstudiesarebasedontheintrinsicpropertiesofnanoparticlesandtheirapplicationinclinicalimagingtechnology.Theimagingtechniquesincludepositronemissiontomography,single-photonemissioncomputedtomography,computerizedtomography,magneticresonanceimaging,opticalimaging,andultrasoundimaging.

简介：Substratecharacterizationisthemainstayofablationforventriculartachycardia(VT).Althoughtheuseofelectroanatomicvoltagemapping(EAVM)intheelectrophysiology(EP)laboratoryhasenabledreal-timeapproximationofmyocardialscar,ithaslimitations.Thisisrelatedtothesubjectiveandtediousnatureofvoltagemappingandthechallengesofdefiningthetransmuralityofscar.Variousnoninvasivemethodsofscarassessmenthaveemerged,withmagneticresonanceimaging(MRI)beingthemostaccurate.IntegratedMRIandelectroanatomicvoltagemappingstudiesdemonstrategoodcorrelation.Nonetheless,MRIhasadvantages.Theseinclude(1)preprocedureidentificationofepicardialandintramuralscar,(2)assessmentofablativelesionformationafterunsuccessfulablations,(3)identifi-cationofheterogeneousregionsofscar,wherecriticalconductingchannelsarelikelytooccur,and(4)predictivevalueintheassessmentofsuddencardiacdeath(SCD).Integrationofscarimaginginventriculartachycardiaablationandriskstratificationhasgreatpotentialtoadvancethepracticeofarrhythmiamanagement.

简介：AbstractBackground:Three-dimensional (3D) fusion imaging has been proved to be a promising neurosurgical tool for presurgical evaluation of tumor removal. We aim to develop a scoring system based on this new tool to predict the resection grade of medial sphenoid wing meningiomas (mSWM) intuitively.Methods:We included 46 patients treated for mSWM from 2014 to 2019 to evaluate their tumors' location, volume, cavernous sinus involvement, vascular encasement, and bone invasion by 3D multimodality fusion imaging. A scoring system based on the significant parameters detected by statistical analysis was created and evaluated.Results:The tumor volumes ranged from 0.8 cm3 to 171.9 cm3. A total of 39 (84.8%) patients had arterial involvement. Cavernous sinus (CS) involvement was observed in 23 patients (50.0%) and bone invasion was noted in 10 patients (21.7%). Simpson I resection was achieved in 10 patients (21.7%) and Simpson II resection was achieved in 17 patients (37.0%). Fifteen patients (32.6%) underwent Simpson III resection and 4 patients (8.7%) underwent Simpson IV resections. A scoring system was created. The score ranged from 1 to 10 and the mean score of our patients was 5.3 ± 2.8. Strong positive monotonic correlation existed between the score and resection grade (Rs = 0.772, P < 0.001). The scoring system had good predictive capacity with an accuracy of 69.60%.Conclusions:We described a scoring system that enabled neurosurgeons to predict extent of resection and outcomes for mSWM preoperatively with 3D multimodality fusion imaging.Trial registration:Retrospectively registered