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  • 简介:OnthehistoricdayofSeptember9,1993,IsraeliPrimeMinisterYitzhakRabinandPLOChairmanYasserAraratdeclaredrecognitionofeachotherbyanex-changeofletters.Fourdayslater,onSeptember13,thetwosidessignedthe"DeclarationofPrinciplesonInterimSelf-governmentArrangements"inWashing-tonatameetingpresidedoverbyAmericanPresidentBillClinton.ThenewaccordisanothersignificantbreakthroughintheMiddleEastpeaceprocessaftertheCampDavidAgreementreachedbetweenIsraelandEgyptin1978.Inviewofthefact

  • 标签: Israel letters BREAKTHROUGH Minister EAST Chairman
  • 简介:Humanp100proteinconsistsoffourrepeateddomainsofstaphylococcalnuclease(SN)-likedomain,aswellasatudor(TD)domainthereafter.WehavepreviouslyshownthattheSN-likedomainofp100interactedwithSTAT6andthelargesubunitofRNApolII,resultingintheenhancementofSTAT6-mediatedgenetranscriptionalactivation.Here,weshowthatSN-likedomainalsointeractedwithCREBbindingprotein(CBP)anddirectlyenhancedtheacetyltransferaseactivityofCBPonhistone.Ontheotherhand,overexpressionofCBPalonehadnoabilitytosignificantlyincreaseSTAT6dependenttranscriptionalactivation,however,togetherwithp100protein,sufficientlyenhancedtheactivationoftranscriptionwhichwasinlinewiththepreviousresultthatp100proteinbridgedSTAT6withCBP.

  • 标签: 共激活剂 组蛋白 乙酰基转移酶 酶活性