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简介:AbstractTo compare efficacy and safety of nab-paclitaxel plus gemcitabine (AG) with nab-paclitaxel plus S-1 (AS) as first-line treatment for metastatic pancreatic cancer, we conducted a retrospective analysis by reviewing medical records of 53 metastatic pancreatic cancer patients in our institution. They received either AG (nab-paclitaxel 125 mg/m2 on days 1, 8 and gemcitabine 1000 mg/m2 on days 1, 8) or AS (nab-paclitaxel 125 mg/m2 on days 1, 8 and S-1 80-120 mg on days 1-14) chemotherapy. We found that AS had higher objective response rate (36% vs 21.4%), better disease control rate (84% vs 75%), prolonged time to progression (TTP, 7.1 vs 5 months), and improved overall survival (OS, 15.3 vs 12 months) when compared with AG. In Cox proportional hazards model, sex was significantly associated with TTP (P value=.031) and metastatic sites plus treatment after progression were significantly associated with OS (P value=.028 and .01, respectively). The incidence rate of chemotherapy-related adverse events was similar in both groups. Neutropenia (50% and 60%, all grade; 21.4% and 36%, grade 3 or 4, in AG and AS group) and sensory neuropathy (21.4% and 24%, all grade; 3.6% and 4%, grade 3 or 4, in AG and AS group) were the most common hematologic and non-hematologic toxicity. Thus, we believed that AS is a reasonable and convenient alternative for patients treated with AG as first-line chemotherapy for metastatic pancreatic cancer.
简介:摘要:随着我国的城市聚落和工厂越来越多,各类仪器应用于各处不同的地方,仪器的使用方法也都有着一定的区别,所以说学习如何科学的使用仪器成为了很多企业和学校的重要学习内容。仪器在这个时代中是一种重要的资源,加强对仪器的管理和提高仪器的利用率对于科学技术的发展有着重要的推进作用。
简介:摘要:某石化公司25万吨/年Unipol气相流化床工艺,在聚乙烯的生产过程中,回收系统的冷凝器出口温度始终偏高,使得回收效率大幅降低,装置的物耗和异戊烷消耗偏高,故本次利用Aspen Plus软件对该装置回收系统进行优化模拟,使回收量达到最大值,并设计出优化方案,最终达到节能减排的模拟目标。
简介:【摘要】KWL Plus模式作为一种开放的“读写教学”理论,在实现阅读与写作有效结合的基础上,突出学生的主体地位,强调学生思维能力的培养。文章结合教学案例,探析如何利用KWL Plus模式设计读写教学活动,实现从低阶思维到高阶思维的训练,最终在教学中实现英语学科核心素养的落实。
简介:摘要:随着中医药分析测试技术的快速发展,各中医药学科每年都要花费大量资金用于大型分析仪器的更新和引进,而这些大型分析仪器存在重复购置,共享程度低和使用效益低的现象。本文在分析我校仪器共享平台建设现状的基础上,对分析仪器共享平台建设进行了探索。
简介:AbstractObjective:This study was performed to compare the efficacy and safety of methotrexate (MTX) plus prednisolone versus prednisolone monotherapy in patients with erythema nodosum leprosum (ENL).Methods:This comparative clinical study was performed in the Chittagong Medical College Hospital, Bangladesh from June 2018 to December 2019. Nineteen patients were selected according to inclusion criteria and randomly allocated to either the MTX plus prednisolone group (Group A, n= 10) or the prednisolone monotherapy group (Group B, n = 9). All patients were followed up until the end of the 6-month duration of therapy to observe the clinical outcomes and adverse effects.Results:All patients in both groups showed significant improvement (P= 0.005 and P= 0.008 in Group A and B, respectively). However, prednisolone-related adverse events were more frequent in Group B.Conclusion:The present study has demonstrated that a combination of prednisolone and MTX is a safer and more effective treatment than steroid monotherapy in ENL patients including the healing of nodules. However, this combination therapy did not appear to have a significant steroid-sparing effect, possibly because of the small sample size and short study period. Therefore, a well-designed multicenter randomized controlled trial is recommended for validation of MTX with prednisolone for the management of ENL.
简介:摘 要:根据光电仪器的光学部件、机械部件、电子部件的三大部分的故障模式,探讨仪器的平均无故障时间,为仪器的预防性维修提供借鉴。
简介:摘要目的比较UBM、A超、Orbscan、IOL Master 700及IOL Master 5.0这五种仪器测量前房深度结果的差异性、相关性及一致性。方法选取2018年1月至3月郑州市第二人民医院眼科门诊就诊患者63例(126眼)的资料,其中男30例(60眼)的资料,女33例(66眼)。年龄19~71岁,平均(30.13±10.73)岁。分别采用上述五种仪器测量前房深度,结果进行统计学分析。结果UBM、A超、Orbscan、IOL Master 700及IOL Master 5.0测得前房深度平均值依次为(3.08±0.29)mm、(3.11±0.35)mm、(2.98±0.28)mm、(3.07±0.28)mm,及(3.46±0.36)mm。五组数据相比差异有统计学意义(F=16.422,P=0.000),其中IOL Master 5.0测量值与其它四组测量值之间差异有统计学意义,其它的四组数据之间差异无统计学意义(P=0.160)。五组数据间有较好的一致性均呈线性相关(Pall=0.000)。结论五种仪器测量前房深度具有较好的相关性、一致性,其中前四种仪器测量前房深度时相互之间可以替代,而IOL Master 5.0的前房深度测量值较其它四种仪器的测量值偏高。
简介:摘 要:力学计量仪器的精准性是决定其整体性能的重要指标。为了提升仪器性能参数,避免人为性的误差问题,就要加强对力学计量仪器检定工作的分析,了解关键要点以及完善措施,进而提升力学计量仪器检定精准性。基于此,本文主要对力学计量仪器检定的相关问题进行了简单的探讨分析。
简介:摘 要:力学计量仪器的精准性是决定其整体性能的重要指标。为了提升仪器性能参数,避免人为性的误差问题,就要加强对力学计量仪器检定工作的分析,了解关键要点以及完善措施,进而提升力学计量仪器检定精准性。基于此,本文主要对力学计量仪器检定的相关问题进行了简单的探讨分析。
简介: 摘 要:仪器仪表在长期使用过程中会产生漂移,进而降低准确度,使最终产品的质量受到影响。所以仪器仪表校准是一项非常必要的工作,通过校准可以将仪表仪器的测量结果的准确度控制在所要求的指标范围内。本文以此为出发点,对仪器仪表校准的质量控制措施进行探讨和分析,希望能够为规范仪器仪表校准过程提供建议。 关键词:仪器仪表 ; 校准质量 ; 控制措施 无论是出于提升产品质量的考虑,还是为了遵循行业规范和质量体系要求,或是出于安全角度,对仪器仪表进行校验都是非常必要的。只有通过定期校验,才能够减少仪器仪表在使用过程中产生的漂移,保证测量结果的准确性和可靠性,这对于保证产品质量、优化生产过程以及提高产能等都是有积极作用的。仪器仪表校准工作会受到很多因素的影响,比如人为因素、外部环境、设备因素等,要想做好仪器仪表校准工作就必须全面控制影响校准质量的因素。