简介:1IntroductionItisaprivilegeforme,asSecretary-GeneraloftheRio+20Conference,tobeherewithallofyou.OnbehalfoftheUnitedNations,letmeexpressmysinceregratitudetotheGlobalMayor'sForumforthisimportantcontributiontothepreparationsfortheUnitedNationsConferenceonSustainableDevelopment(Rio+20).
简介:正Cafiu'sSecretary-GeneralNiJianattendedUNSustainableDevelopmentConference(Rio+20)heldinRiodeJaneiro,BrazilfromJune16to21.Thisisanotherlarge-scale,high-leveleventinglobalsustainabledevelopmentafterthe1992UNEnvironmentandDevelopmentConference.The
简介:AbstractObjectives:To investigate the prevalence of ACADM pathogenic variants, c.985A>G and c.199T>C, for medium chain acyl CoA dehydrogenase deficiency (MCADD) in a healthy population in the southern region of Brazil.Methods:This was an observational cross-sectional study with a convenience sampling strategy. The participants were recruited from the blood bank of the Hospital de Clínicas of Porto Alegre, Brazil. A total of 1000 healthy individuals from the state of Rio Grande do Sul were included. Genotyping for the c.199T>C and c.985A>G variants was performed using real-time polymerase chain reaction (PCR) and the PCR-restriction fragment length polymorphism (RFLP) technique, respectively. Individuals considered heterozygous for c.985A>G were subjected to additional acylcarnitine profile analysis using tandem mass spectrometry. Carrier frequency was obtained by calculating the ratio of heterozygous individuals to the total number of individuals analyzed and reported with a 95% confidence interval. Allele and genotype frequencies were calculated based on the Hardy-Weinberg equilibrium.Results:The c.985A>G variant was detected as heterozygotes in three individuals (frequency of the heterozygous genotype = 1:333, allele frequency= 0.0015, minimum frequency of MCADD= 1:444,444) whose acylcarnitine profiles were within normal limits. The c.199T>C variant was not identified.Conclusions:Considering the small sample size and associated allelic heterogeneity with MCADD, these findings are believed to denote the rarity or underdiagnosis of MCADD in southern Brazil. This study provides evidence for the need for further investigation to ascertain the contribution of these diseases to child morbidity and mortality in the country.
简介:网络财务是一种基于网络环境计算机技术的财务管理系统,它以财务管理为核心,业务管理与财务管理一体化,整合实现企业电子商务,实现种种远程操作,开展事中动态会计核算与在线财务管理,处理电子单据相应进行电子货币结算,进一步实现管理的数字化,并最终实现管理信息化,是电子商务的重要组成部分。网络会计是建立在网络环境基础上的会计信息系统,是指在互联网环境下对各种交易和事项进行确认、计量和披露的会计活动,其所需处理的各种数据越来越多地以电子形式直接存储于计算机网络之中,对企业各种交易事项进行确认、计量和披露,是电子商务的重要组成部分。二者紧密联系,又有所不同。