简介：Theβ-carboxylicgroupplaysanimportantroleinthepeptideformation,esterificationandtheesterexchangeatthephosphorylgroupofN-phosphorylatedasparticacid.

简介：ＰＲＥＰＡＲＡＴＩＯＮＯＦＮ－ｔ－ＢＵＴＹＬＯＸＹＣＡＲＢＯＮＹＬ－Ｏ￣α－９－ＦＬＵＯＲＥＮＹＬＭＥＴＨＹＬＥＳＴＥＲＯＦＡＳＰＡＲＴＩＣＡＣＩＤ￥ＺｏｎｇＪｉｎＨＡＮ；ＺｈｅｎＫａｉＤＩＮＧａｎｄＱｉＫａｉＺＨＡＮＧ（ＢｅｉｊｉｎｇＩｎｓｔｉｔｕ...

简介：在这研究，新有点磁性、光的Fe3O4/CdTenanocomposites的准备被表明。SuperparamagneticFe3O4nanoparticles被铁、铁的离子的热水的一起沉淀首先综合，与丁氨二酸酸与tetramethylammonium氢氧化物(TMAOH)和化学激活由他们的表面的修正列在后面。修改表面的Fe3O4nanoparticles当时与CdTe量点(QD)是covalently涂的，它与mercaptoacetic酸(MPA)被修改，到通过Fe3O4和carboxyl的表面上的氨基的组的协作的Fe3O4/CdTe磁性、光的nanocomposites在CdTeQD上组织的形式。同样综合的nanocomposites的结构和性质被描绘。nanocomposites与40-50nm，黄绿色的排放特征和房间温度强磁性的一条平均直径拥有了结构，这被显示。荧光和nanocomposites的紫外力的吸收系列显示出CdTeQD与那些作比较的蓝移动。蓝移动的机制被介绍。nanocomposites与8.9emu/g的浸透磁化保留了铁磁性的性质。

简介：glutamic酸(LG)和丁氨二酸酸(ASP)的随机的共聚物，poly(LG-co-ASP)，能成功地与debenzylation经由N-carboxyanhydride戒指开始copolymerization的联合与设计作文被综合。-benzyl-L-glutamateN-carboxyanhydride(BLG-NCA)和-benzyl-LaspartateN-carboxyanhydride(BLA-NCA)的戒指开始copolymerizations被使用不同的胺包括执行象开始者的triethylamine(茶)，diethylamine，n-hexylamine(NHA)，triphenylamine，二苯胺或苯胺。所有6胺是高度有效的poly变得明确(BLG-co-BLA)共聚物与尽管聚合经由不同机制(正常的胺机制或/并且激活的单体机制)继续了，设计了作文，它基于胺的化学结构。分子的重量(BLG-co-BLA)poly，共聚物能被茶集中和聚合时间调停。然后，debenzylation(BLG-co-BLA)poly，共聚物被进行准备相应吸水的随机的共聚物(LG-co-ASP)poly以ASP结构的单位与子单元组织。LG结构的单位在的内容(LG-co-ASP)poly，共聚物在NCA单体BLG-NCA与那些匹配在NHA或茶开始并且接近了理论线的戒指洞copolymerizations喂。diblock共聚物(BLG-b-BLA)能被BLGNCA和BLA-NCA的顺序的增加也poly经由生活NCA戒指洞copolymerization综合。

简介：Serine,oneofthenonessentialaminoacids,isofprincipalinterestbecauseofitscapabilitytoformmagic-numberionicclusters,whichprovidearemarkablepreferenceforhomochirality.WithL-asparticacidastheprecursor,thisstudyprovidesexperimentalevidenceforserineformationinweakacidifiedaqueoussolutionsinthepresenceofiron,withexposuretosunlight,whichsimulatesthenaturalconditionsoftheprebioticaqueousenvironment.Theresultantmixtureisdirectlyanalyzedviadesorptionelectrosprayionizationmassspectrometry(DESI-MS),withoutanysamplepreseparation.Theserinemonomerissuccessfullydetectedasprotonatedmolecules,givingapeakatm/z106,whichisconfirmedbytheMS/MSfragments.Protonatedserineoctamer(m/z841)isalsoobservedwithsignificantabundanceintheMSspectraandisconfirmedbytheMS/MSdata,whichshowstheformationoftheserineoctamerbyasynthesizedserineintheresultantmixture.ItisalsofoundthattheserineoctameryieldedequivalentabundanceintheDESImassspectrainawidepHrange(pH=1-5),andthatexistenceofferroussaltandsunshineareessentialfortheconversionofasparticacidtoserineintheacidicwatersolution.

简介：SpinaldorsalhornN-Methyl-D-asparticacidreceptor2B(NR2B)overexpressionplaysanimportantroleintheproductionandmaintenanceofneuropathicpain.BecausesmallinterferingRNA(siRNA)caninhibitNR2Bexpression,siRNAmayprovideanovelapproachtotreatneuropathicpainandpossiblynerveinjury.However,anefficientandsafevectorforNR2BsiRNAhasnotbeendiscov-ered.Thisstudyshowsthatawatersolublelipopolymer(WSLP)comprisedoflowmolecularweightpolyethyleneimine(PEI)andcholesterolcandeliversiRNAtargetingNR2Bforthetreatmentofneuropathicpain.ResultsshowthatintrathecalinjectionofWSLP/siRNAcomplexesfor3daysin-hibitNR2BgeneexpressionwithreductionsinmRNAandproteinlevelsby59%and54%,respec-tively,comparedwithcontrolrats(P<0.01).InjectionofWSLPcomplexedwithscrambledsiRNA,orPEIwithsiRNAdidnotshowthisinhibitoryeffect.Moreover,injectionofWSLP/siRNAcomplexessignificantlyrelievedneuropathicpainat3,7,12,and21days,whileinjectionofWSLPwithscrambledsiRNAorPEIwithsiRNAdidnot.TheseresultsdemonstratethatWSLPcanefficientlydeliversiRNAtargetingNR2Binvivoandrelieveneuropathicpain.