简介：无

简介：AbstractCardiovascular disease (CVD) remains the leading cause of death worldwide. Therefore, exploring the mechanism of CVDs and critical regulatory factors is of great significance for promoting heart repair, reversing cardiac remodeling, and reducing adverse cardiovascular events. Recently, significant progress has been made in understanding the function of protein kinases and their interactions with other regulatory proteins in myocardial biology. Protein kinases are positioned as critical regulators at the intersection of multiple signals and coordinate nearly every aspect of myocardial responses, regulating contractility, metabolism, transcription, and cellular death. Equally, reconstructing the disrupted protein kinases regulatory network will help reverse pathological progress and stimulate cardiac repair. This review summarizes recent researches concerning the function of protein kinases in CVDs, discusses their promising clinical applications, and explores potential targets for future treatments.

简介：Clinicaldecision-makingiswhatallcardiovascularphysiciansdo.Thepurposeofdecision-makingistomakethediagnosis,decideonappropriatetherapyandestimatetheprognosisoftheindividualpatient.Regardingtheprognosis,populationprognosticdataisusedbutthismayormaynotapplytotheindividualpatient.LVfunction,nomatterhowitisdeterminedseemstocorrelatebestwithprognosis.Butweneedtorememberthatprognosticationoftheindividualis,atbest,aneducatedguess.

简介：Cardiovasculardisease(CVD)isthenumberonecauseofmortalityworld-wideandplacesahighmedicalandsocioeconomicburdenondevelopingcountries.OurunderstandingofCVDanditsevolutionoverthelast100yearshasalteredconsiderably.ReasonsfortheincreasedrateofCVDinthedevelopingworldincluderapidurbanizationandthedemographicshiftknownasthemodernepidemiologictransition.ThecaseforinterventionisbasedonbothmajorhumanandeconomicimpactsofCVD.Ithasbeenestimatedthatcost-effectiveinterventionsindevelopingcountrieswithahighburdenofCVDcouldresultinaprojected24millionlivessaved.ThisreductioninCVDmortalitycouldreduceeconomiccostsby$8billion.Approachestointerventioninclude:1)cardiovascularhealthpromotionandCVDpreventionand2)actionplansadvocatedbytheWorldHealthOrganization.

简介：Background:Depressiondisordercoexistsinchronicdiseaseswithsomaticdiseasesandhashighmorbidity,disabilityandmortality.Currentresearcheshaveconfirmedthatdepressionmaybecausedbycoronaryheartdisease,hypertensionandheartfailure.Meanwhile,cardiovasculardiseasesmaycauseorworsendepression,leadingtoprolongedhospitalizationandcomplications.

简介：Cardiovasculardisease(CVD)istheleadingcauseofdeathworldwide.ThisarticlefocusesoncurrentguidelinesfortheprimarypreventionofCVDandaddressesmanagementofkeyriskfactors.Dietarymodification,weightloss,exercise,andtobaccousecessationarespecificareaswherefocusedeffortscansuccessfullyreduceCVDriskonbothanindividualandasocietallevel.Specificareasrequiringmanagementincludedyslipidemia,hypertension,physicalactivity,diabetes,aspirinuse,andalcoholintake.Thesepreventiveeffortshavemajorpublichealthimplications.Astheglobalpopulationcontinuestogrow,healthcareexpenditureswillalsorise,withthepotentialtoeventuallyoverwhelmthehealthcaresystem.ThereforeitisimperativetoapplyourcollectiveeffortsonCVDpreventiontoimprovethecardiovascularhealthofindividuals,communities,andnations.

简介：SincePresidentObamaannouncedthePrecisionMedicineInitiativeintheUnitedStates,moreandmoreattentionhasbeenpaidtoprecisionmedicine.However,clinicianshavealreadyusedittotreatconditionssuchascancer.Manycardiovasculardiseaseshaveafamilialpresentation,andgeneticvariantsareassociatedwiththeprevention,diagnosis,andtreatmentofcardiovasculardiseases,whicharethebasisforprovidingprecisecaretopatientswithcardiovasculardiseases.Large-scalecohortsandmultiomicsarecriticalcomponentsofprecisionmedicine.Herewesummarizetheapplicationofprecisionmedicinetocardiovasculardiseasesbasedoncohortandomicstudies,andhopetoelicitdiscussionaboutfuturehealthcare.

简介：Allorganisms,rangingfromsingle-celledorganismstohumans,demonstratecircadianrhythmsthatarenear24-hpatternsthatarepresentindependentofenvironmentalcues.Disruptionofthisprocess,calledcircadianmisalignment,isassociatedwithdeleterioushealthoutcomes.Themostextremeexampleofthismisalignmentisshiftwork,andthereisevidencesuggestingastrongassociationbetweenshiftworkandcertaincardiovascularoutcomes.Theoutcomesofmoststudiesincludeobesity,metabolicsyndrome,hypertension,type2diabetesmellitus,atrialfibrillation,andcardiovascularevents.Inthisarticlewereviewthecurrentliteraturewithanemphasisonwomen’scardiovascularhealth.Thedataareconflicting,andthereisapaucityofrobustevidencewithregardtowomen’scardiovascularhealthandcircadianmisalignment.Morestudiesareneededtobetterdelineatethesexdifferencesaswellasthepathophysiologyoftheassociationsbetweencircadianmisalignmentandcardiovasculardiseasessothatwecanprovidepatientswithmorepersonalizedcare.

简介：无

简介：ThewealthofDNAdatageneratedbythehumangenomeprojectcouplingwithrecentlyinventedhigh-throughputgeneexpressionprofilingtechniqueshasdramaticallyspeduptheprocessforbiomedicalresearchersonelucidatingtheroleofgenesinhumandiseases.Onepowerfulmethodtorevealinsightintogenefunctionsisthesystematicanalysisofgeneexpression.Twopopularhigh-throughputgeneexpressiontechnologies,microarrayandSerialAnalysisofGeneExpression(SAGE)arecapableofproducinglargeamountsofgeneexpressiondatawiththepotentialofprovidingnovelinsightsintofundamentaldiseaseprocesses,especiallycomplexsyndromessuchascardiovasculardisease,whoseetiologiesareduetomultiplegeneticfactorsandtheirinterplaywiththeenvironment.MicroarrayandSAGEhavealreadybeenusedtoexaminegeneexpressionpatternsofcell-culture,animalandhumantissuesmodelsofcardiovasculardiseases.Inthisreview,wewillfirstgiveabriefintroductionofmicroarrayandSAGEtechnologiesandpointouttheirlimitations.Wewillthendiscussthemajordiscoveriesandthenewbiologicalinsightsthathaveemergedfromtheirapplicationstocardiovasculardiseases.Finallywewilltouchuponpotentialchallengesandfuturedevelopmentsinthisarea.

简介：AbstractObjective:Cardiovascular diseases are associated with an increased risk of depression, but it remains unclear whether treatment with cardiovascular agents decreases or increases this risk. The effects of drugs on individual usage are also often unknown. This review aimed to examine the correlation between depression and common cardiovascular drugs, develop more potent interventions for depression in cardiovascular patients, and further research on the bio-behavioural mechanisms linking cardiovascular drugs to depression.Data sources:The data in this review were obtained from articles included in PubMed, EMBASE, and Web of Science.Study selection:Clinical trials, observational studies, review literature, and guidelines about depression and cardiovascular drugs were selected for the article.Results:We systematically investigated whether the seven most used cardiovascular drugs were associated with altered risk of incident depression in this literature review. Statins have been proven to have antidepressant effects. Some studies believe angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blocker (ARB) can exert an antidepressant influence by acting on the renin-angiotensin system, but further clinical trials are needed to confirm this. Beta-blockers have previously been associated with depression, but the current study found no significant association between beta blockers and the risk of depression. Aspirin may have antidepressant effects by suppressing the immune response, but its role as an antidepressant remains controversial. calcium channel blockers (CCBs) can regulate nerve signal transduction by adjusting calcium channels, but whether this effect is beneficial or harmful to depression remains unclear. Finally, some cases have reported that nitrates and diuretics are associated with depression, but the current clinical evidence is insufficient.Conclusions:Statins have been proven to have antidepressant effect, and the antidepressant effects of ACEIs/ARB and aspirin are still controversial. CCBs are associated with depression, but it is unclear whether it is beneficial or harmful. No association has been found with β-blockers, diuretics, and nitrates.

简介：Anticoagulationisimperativetoreducetheincidenceofthromboticcomplicationsinpatientsundergoingpercutaneousinterventionalcardiovascularprocedures;however,thisisattheexpenseofincreasedriskofbleeding.Theoptimalanticoagulationstrategyfortheseproceduresremainsunclear.Unfractionatedheparinisthemostcommonlyusedanticoagulantduringinterventionalprocedures,buthasseverallimitations,suchasrelativelyhighincidenceofbleedingevents,occurrenceofheparin-inducedthrombocytopenia,andaparadoxicalthromboticeffect.Contemporarystudieshavedemonstratedthatbivalirudindecreasestheoccurrenceofbleedingcomplications,butpotentiallyincreasestheriskofacutestentthrombosis.Thisreviewdiscussesthepharmacologyofbivalirudinanditscurrentclinicalapplicationinpatientsundergoingpercutaneouscoronaryinterventionandtranscatheteraorticvalvereplacementprocedures.

简介：Inclinicalpractice,avarietyofsyndromesareassociatedwithcardiovasculardiseaseandhavecharacteristicfindings.Mostofthemareanautosomaldominantgeneticdisorderandhavedifferenttypesofcardiovascularabnormalities,includingelectrocardiographicconductiondefects,arrhythmias,cardiomyopathy,vascularandvalvulardiseases,cardiacseptaldefects,andpulmonaryproblems.Thereisagrowingneedforphysicianstopaymoreattentiontothesesyndromes.

简介：在Andrology(AJA)的亚洲杂志的这期，几位专家在心血管的风险上在内长、外长的睾丸激素(T)的潜在、知道的效果上考察了最近的数据。在由迈耶和Wittert的评论，低内长的浆液T看起来在象Klinefelter症候群和老人那样的某些人口与心血管的疾病和全面死亡的更高的风险被联系，然而并非在有先天的hypogonadotropichypogonadism.1的人这个协会是否或是否是原因的低浆液睾丸激素是另外的风险因素的一个标记因为象肥胖，糖尿病mellitus，或另外的全身的疾病那样的心血管的疾病是未知的。在在传播内长的睾丸激素和它的主要代谢物之间的关系的Yeaps评论，dihydrotestosterone，和estradiol，他提起可能与基于一样的流行病学的研究的内长的睾丸激素和dihydrotestosteroneconcentrations.2有关的心血管、脑血管的风险上有微分效果的挑衅性的假设，Yeap要求可能为传播内长的雄激素集中有一条U字形的曲线以便更低并且hig岸在大药方数据库的研究的小心地做的评论示威(包括>200000个人)那睾丸激素治疗没与全面死亡，心肌的梗塞，击，或深静脉的血栓events.3被联系

简介：Introduction,ThemembersoftheCardiovascularDivisionattheUniversityofFlorida,DepartmentofMedicinehavelongrecognizedtheneedforcardiacrehabilitationofourpatients.PriortoJuly2016,arehabilitationprogramforcardiovascularpatientsattheUniversityofFloridadidnotexist.InJuly2016weinitiatedatotalpatientrehabilitationprogramforallcardiacpatients,whethertheirdiseasewasrelatedtomyocardialischemia,myocardialinfarction,arrhythmia,orheartfailure.Whenbeginningsuchaprogramthereareseveraltopicsthatmustbeconsidered.Theseincludespaceforpatientsandequipment,aswellaspersonneltostafftheprogram.Initially,personnelshouldincludeaphysiologist,anurseandaphysician.

简介：

简介：APeruviannative,Dr.VelardeearnedhermedicaldegreefromtheNewYorkUniversitySchoolofMedicineinNewYorkandwentontocompleteherresidencytraininginInternalMedicineatColumbiaPresbyterianMedicalCenterandCardiovascularDiseasefellowshiptrainingatMountSinaiHospitalinNewYorkandBostonUniversity.Dr.GladysP.VelardeisAssociateProfessorofMedicine/CardiologyatTheUniversityofFlorida,JacksonvillewhereshedirectstheWomen’sCardiovascularHealthProgramandisDirectoroftheCardiovascularDiseaseFellowshiptrainingprogram.

简介：ObstructiveSleepApnea(OSA)isacommonchronicdisorderthataffects5–10%oftheUSpopulationwithahigherprevalenceinmencomparedtowomenby2:1inpopulationstudies.Bycontrast,inpatientswithcardiovasculardisease,itsprevalencecanexceed50%dependingonthespecificdisordersurveyed.Althoughsexdifferenceshavebeenwelldescribedforcardiovascularriskfactors;existingdataregardingtheimpactofsexontherelationshipbetweenOSAandcardiovascularoutcomesiscontroversial.Similarly,whilethereisstrongevidenceforincreasedprevalenceofcardiovascularconditions,suchassystemichypertension,atrialfibrillation,aswellasheartfailureamongstpatientssufferingfromOSA;conflictingevidenceexistsregardingtheincidenceandbidirectionalrelationshipbetweenthemaswellastheimpactoftreatmentofOSAoncardiovascularoutcomes.Inthispaper,wewillreviewtheassociationsbetweenOSAandcardiovasculardiseasesinwomen.Thedataonsexdifferencesislimited,duetoanumberofreasons,including,butnotlimitedtolatepresentationofOSAinwomen,difficultiesindiagnosingbothOSAandcardiovasculardiseasesinwomenandstillsuboptimalinclusionofadequatenumberofwomeninclinicaltrials.MorestudiesareneededtobetterdelineatesexdifferencesintheclinicalpresentationaswellasthepathophysiologyoftheassociationsbetweenOSAandcardiovasculardiseasessothatwecanprovidepatientswithmorepersonalizedcare.

简介：Depression/anxiety-relateddisordersandpsychosocialstresshavebeenimplicatedascardiovasculardisease(CVD)riskfactors.Womenareatconsiderableriskforaffectivedisordersandreportgreaterseverityfrompsychosocialstress,comparedtomen.Affectivedisordersandcardiovasculardiseaselikelyshareunderlyingpathophysiologicalmechanismsthatarepotentiatedamongwomen–especiallyyoungerwomen.Environmentalstressorsthatthreatenthesafety,security,andstatusofanindividualareappraisedbythebrain,producingacascadeofevokedphysiologicalandcognitiveresponses.Intheshortterm,theseprocessesovercomestressors,butcomewithlong-termhealthimplications.Chronicpsychosocialstressleadstoadysregulationofthestressresponsesystemsthatcanleadtoaheightenedstressappraisalschemacalledtheunpredictabilityschema,aconstructthatmightarguablyplacewomenatheightenedriskforCVD.

简介：Thehumancardiovascularsystemisaclosedloopandcomplexvascularnetworkwithmulti-scaledheterogeneoushemodynamicphenomena.Here,wegiveaselectivereviewofrecentprogressinmacro-hemodynamicmodeling,withafocusongeometricalmulti-scalemodelingofthevascularnetwork,micro-hemodynamicmodelingofmicrocirculation,aswellasbloodcellular,subcellular,endothelialbiomechanics,andtheirinteractionwitharterialvesselmechanics.Wedescribeindetailthemethodologyofhemodynamicmodelinganditspotentialapplicationsincardiovascularresearchandclinicalpractice.Inaddition,wepresentmajortopicsforfuturestudy:recentprogressofpatient-specifihemodynamicmodelinginclinicalapplications,micro-hemodynamicmodelingincapillariesandbloodcells,andtheimportanceandpotentialofthemulti-scalehemodynamicmodeling.